Browse our latest Structural Biology and Molecular Biophysics articles

The generation of phosphoinositide 3,4,5-trisphosphate causes an increase in the number of TRPV1 ion channels and insulin receptors in the plasma membrane.

Complementary structural biology approaches reveal how an agonist and a covalent inhibitor simultaneously bind to a nuclear receptor.

The dynamical transition between a protein and its surface water is decoupled.

An open-source tool for computational simulations of the human genome has been introduced, enabling the characterization of complex nuclear environments and the interpretation of experimental observations.

In crystallo observation of HNH family I-PpoI nuclease cleaving DNA suggests that one divalent metal ion and a histidine are required for catalysis.

The differential conformational space accessible to the two domains of TRBP, even though they both adopt a canonical dsRBD fold, affect how they interact with target RNAs.

Biophysical experiments, pulse-chase assays, and molecular dynamics simulations reveal how the proteasome targeting signal Fat10 can modulate the structure of substrate proteins to potentially regulate their degradation by the proteasome.

HS-AFM and Principal Component Analysis provide experimental evidence to substantiate the 'proof of principle' regarding the flexible helical twists of actin filaments that regulate the functions of actin-binding proteins.

A comprehensive exploration of α-synuclein (αS) aggregation dynamics from both macroscopic and microscopic perspectives uncovers the intricate mechanisms underlying crowder and salt-induced intensification of αS self-aggregation.

P-Rex1 adopts an inactive, compact conformation that is stabilized by an abundant intracellular molecule and undergoes dynamic changes to extend upon encountering signaling phospholipids in membranes.