Browse our latest Structural Biology and Molecular Biophysics articles

Molecular dynamics simulations reveal that lipid binding at antibody loops and framework regions stabilizes membrane interactions, providing molecular details for neutralization mechanisms and strategies for HIV-1 vaccine development.

Recognition of antigenic ligand by T-cell receptors is a nuanced process where mechanical force can be leveraged to diversify functional outcomes of different T-cells for the same ligand.

Crystallography, molecular dynamics simulations, and biochemical analyses of Calvin-Benson-Bassham sedoheptulose-1,7-bisphosphatase (SBPase) from the microalga Chlamydomonas reinhardtii identify a redox module that controls oligomeric states for the activation of the enzyme.

A camelid single-domain antibody potently and specifically inhibits pyruvate kinases from trypanosomatids.

DyNoPy is able to deconvolute communities from complicated coevolution analysis.

The microenvironment within biomolecular condensates exhibits interfacial behaviors characterized by a combination of hydrophobic and hydrophilic properties.

Structure-based approach identifies a K_ATP-binding compound that has the potential of normalizing insulin secretion in congenital hyperinsulinism by correcting defective K_ATP channel trafficking to the cell surface.

Jyvaskylavirus, the northernmost isolate of the Marseilleviridae family, shows that giant viruses are also part of the boreal Finnish environment and brings structural information with relevance for understanding other viruses.