Browse our latest Structural Biology and Molecular Biophysics articles

Page 15 of 178
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

    Siyu Chen, Tamar Basiashvili ... Elizabeth Villa
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Membrane curvature sensing and symmetry breaking of the M2 proton channel from Influenza A

    James Lincoff, Cole VM Helsell ... Michael Grabe
    Using a combination of all-atom molecular simulation and continuum membrane mechanics, M2 channels from influenza are shown to be stabilized in negative Gaussian curvature regions, such as the neck of budding viral particles, only in C2-symmetric conformations.
    1. Structural Biology and Molecular Biophysics

    Empowering AlphaFold2 for protein conformation selective drug discovery with AlphaFold2-RAVE

    Xinyu Gu, Akashnathan Aranganathan, Pratyush Tiwary
    AlphaFold2's inability to generate non-native conformations for docking is addressed by AI-molecular dynamics method AlphaFold2-RAVE, which produces Boltzmann-ranked conformations, enabling the retrospective discovery of type II kinase inhibitors.
    1. Structural Biology and Molecular Biophysics

    Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

    Po-Lin Chiu, Juan D Orjuela ... Thomas Walz
    Electron crystallography and molecular dynamics simulations show that a cholesterol sandwiched in between two neighboring aquaporin-0 tetramers stabilizes the association between the tetramers and thus promotes array formation.
    1. Structural Biology and Molecular Biophysics

    Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans

    Dipti Ranjan Lenka, Shakti Virendra Dahe ... Atul Kumar
    The new insights into the activation mechanism of Parkin E3 ligase could be useful for designing small-molecule activators against Parkinson’s disease.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    MDverse, shedding light on the dark matter of molecular dynamics simulations

    Johanna KS Tiemann, Magdalena Szczuka ... Pierre Poulain
    Identifying, indexing, and annotating molecular dynamics simulations open data is essential to ensure their proper reuse.
    1. Structural Biology and Molecular Biophysics

    On the pH-dependence of α-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation

    Lukas Frey, Dhiman Ghosh ... Jason Greenwald
    The amyloid polymorph selection that occurs during α-synuclein aggregation is dictated by environmental conditions, in particular pH, with the largest variety of structures being observed near neutral pH.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of the human heparan-α-glucosaminide N-acetyltransferase (HGSNAT)

    Vikas Navratna, Arvind Kumar ... Shyamal Mosalaganti
    First high-resolution structure of HGSNAT-acetyl-CoA complex, that describes the architecture of a novel transmembrane N-acetyltransferase fold and provides a molecular basis for MPS IIIC causing mutation induced destabilization of HGSNAT.
    Version of Record
    Research Article
    • Important
    • Convincing
    • Incomplete
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Insulator-based dielectrophoresis-assisted separation of insulin secretory vesicles

    Mahta Barekatain, Yameng Liu ... Mark A Hayes
    An unbiased separation method reveals distinct subpopulations of insulin secretory vesicles that undergo dynamic remodeling upon glucose stimulation.
    1. Structural Biology and Molecular Biophysics

    Cell chirality reversal through tilted balance between polymerization of radial fibers and clockwise-swirling of transverse arcs

    Hoi Kwan Kwong, Miu Ling Lam ... Ting-Hsuan Chen
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling