Browse our latest Structural Biology and Molecular Biophysics articles

Single-molecule force and fluorescence spectroscopy reveal the structural states and dynamics of E. coli single-stranded DNA binding proteins and the energy landscape of the nucleo–protein complex.

The ligand-binding pocket of the Dishevelled PDZ domain can be occupied by Dishevelled's own highly conserved C-terminus, inducing a closed conformation that is ‘opened’ when Wnt signaling stimulates interaction between Frizzled and Dishevelled.

The Chip/LDB-SSDP complex integrates multiple signals to render TCF/LEF enhancers Wnt responsive.

Rare mutations in the switch III region of Ras can increase its nanoscale clustering, which enhances effector recruitment and downstream signaling.

A structural analysis of the transcription regulator Mot1 in complex with promoter DNA and the proteins TBP and NC2 provides a first structural framework for how a Swi2/Snf2 type remodeler interacts with a histone fold protein:DNA complex.

The bacterial cytolysin synthetase CylM has a eukaryotic lipid kinase fold despite the absence of any clear sequence similarity, and contains adjacent phosphorylation and phosphate elimination active sites and an ordered activation loop in the absence of peptide substrate or regulatory proteins.

Structure/function studies of a plant pathogen effector in complex with a host disease resistance protein domain reveal the molecular basis for recognition and underpin future engineering of immunity in crops.

Soluble αβ-tubulin assembly is regulated by a cage-like molecular complex containing tubulin cofactors and Arl2.

CLR01 is a small molecule that could be an effective topical microbicide to eliminate HIV (and other enveloped viruses), and to antagonize host-encoded amyloid fibrils that promote HIV infection.

Binding of STIL to PLK4's characteristic Polo-box 3 links PLK4 kinase activation to STIL self-association and is a crucial regulatory step for the localized recruitment of downstream factors in centriole duplication.