Browse our latest Structural Biology and Molecular Biophysics articles

Structural and functional studies reveal how a ubiquitous regulator of dynein keeps the microtubule-based motor in a persistent track-bound state.

The crystal structure of a PfRh family protein from a malaria parasite has been solved and shows that PfRh5-which the parasite uses to invade human red blood cells-has a novel protein fold.

Interactions in protein complexes can be predicted from evolutionary information from genomic sequences.

The signal recognition particle only stably engages translating ribosome nascent-chain complexes exposing a functional signal sequence.

Phosphatidic acid influences the gating of voltage-gated K+ channels through a non-specific surface charge mechanism and through a specific interaction between a voltage sensor arginine and the primary phosphate head group on the cytoplasmic membrane leaflet.

Ligand binding to the ectodomain of the insulin-like growth factor receptor destabilises an autoinhibitory inter-subunit interaction, which allows the transmembrane domains to associate and the intracellular regions to autophosphorylate.

Input from computational models has enabled the detection of allosteric communication that modulates the gating mechanism of a bacterial outer-membrane protein.

Building on previous work (Shi et al., 2013), we have used MicroED to determine the structure of catalase at 3.2 Å resolution from a single crystal.