Browse our latest Structural Biology and Molecular Biophysics articles

Cryo-EM structures of the ClpXP protease reveal how protein substrates are bound, show how spiral ClpX hexamers bind symmetry-mismatched heptameric ClpP rings, and suggest mechanisms for processive substrate translocation.

A novel dynamic charge-charge interaction between B56 and a subset of PP2A-B56 substrates is essential for substrate specificity, dephosphorylation and, for KIF4A, binding condensin I.

The structure of a pannexin 1 uncovers the extracellular loops of pannexin 1 as important structural motifs for ion selectivity and channel inhibition.

The structure of pannexin 1, a channel protein with a large pore, has been determined for the first time.

Integrative structural biology reveals a conformational equilibrium in the Box C/D methylation enzyme that regulates the extent of site-specific 2'-O-rRNA methylation in dependence of the RNA sequence.

The automation of cryo-focused ion beam milling enables previously unfeasible cryo-electron tomography projects.

Novel drug-binding sites of TRPC6 could potentially facilitate future design of drugs to treat TRPC6-mediated diseases.

The crucial regulator of brain function, mTOR, signals through distinct macromolecular complexes to control how synaptic vesicles are released from the presynaptic terminal.

The common post-translational modification trans-4-hydroxy-L-proline is reversed by gut microbes with the help of hydroxyproline dehydratase (HypD), an enzyme that performs a radical chemical mechanism.

The intermediate state conformation of the human KCNQ1 potassium channel voltage sensor domain was determined, validated, and shown to be conductive under physiological conditions.