Browse our latest Structural Biology and Molecular Biophysics articles

By combining structure-based computational predictions and a thorough structural analysis, a highly thermostable enzyme, alcohol dehydrogenase, has been engineered.

Time-resolved crystallography provides insight into the photochemical reactions in photoreceptor proteins, explaining the earliest steps of how plants, fungi and bacteria sense red light.

Extremely short X-ray pulses from a free-electron laser are helping to clarify how phytochromes respond to light, but puzzles remain.

In situ cryo-electron tomography resolves individual photosynthetic complexes within native thylakoid membranes, revealing how thylakoid architecture sorts proteins into discrete membrane domains.

Polyunsaturated fatty acid analogues show selectivity for different cardiac ion channels, suggesting their potential use for the treatment of different subtypes of Long QT Syndrome.

GTP binding induces rearrangement of S-OPA1 assembly on membrane and thus triggers membrane remodeling with reduced curvature.

Structural, biophysical and physiological analysis reveals how yeast cell surface adhesins evolved to confer self-nonself discrimination in single cells and whole populations.

Differences in the flexible linkers connecting the kinase domain to an oligomeric hub modulate CaMKII activity by changing the balance between activating and inhibitory autophosphorylation.

Structures of the non-canonical potassium channel TMEM175 in open and closed states reveal unique mechanisms for channel gating and the selective permeation of K+ ions.

Understanding of bacterial protein degradation is illuminated by cryo-EM structures of the substrate-bound ClpXP complex from Neisseria meningitidis at 2.3 to 3.3 Å resolution.