Browse our latest research

Page 10 of 1,735
    1. Neuroscience

    Neural mechanisms of credit assignment for delayed outcomes during contingent learning

    Phillip P Witkowski, Lindsay JH Rondot ... Erie Boorman
    Orbitofrontal cortex and hippocampus reinstate representations of causal choices to associate with delayed outcomes, and the frontal pole supports this credit assignment process by maintaining pending choices during interim decisions.
    1. Cell Biology
    2. Immunology and Inflammation

    UFMTrack, an Under-Flow Migration Tracker enabling analysis of the entire multi-step immune cell extravasation cascade across the blood-brain barrier in microfluidic devices

    Mykhailo Vladymyrov, Luca Marchetti ... Britta Engelhardt
    The established under-flow migration tracker (UFMTrack) framework allows for automated and scalable studies of immune cell interactions with and extravasation across endothelial monolayer under flow in vitro.
    1. Neuroscience

    Non-allometric expansion and enhanced compartmentalization of Purkinje cell dendrites in the human cerebellum

    Silas E Busch, Christian Hansel
    A comparative study of Purkinje dendrite morphology, input arrangement, and regional subtype distribution shows human cells evade constraint by cortical thickness to be both quantitatively and qualitatively distinct from mouse.
    1. Structural Biology and Molecular Biophysics

    Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes

    Christopher T Schafer, Raymond F Pauszek III ... David P Millar
    The conformational dynamics and landscapes of the related chemokine receptors CXCR4 and ACKR3, revealed by single-molecule analysis, provide mechanistic insights into differences in constitutive activity, ligand promiscuity, and effector coupling.
    1. Microbiology and Infectious Disease

    Serial ‘deep-sampling’ PCR of fragmented DNA reveals the wide range of Trypanosoma cruzi burden among chronically infected human, macaque, and canine hosts, and allows accurate monitoring of parasite load following treatment

    Brooke E White, Carolyn L Hodo ... Rick L Tarleton
    A vastly improved PCR-based approach provides a long-sought test of cure and parasite load monitoring tool for Chagas disease.
    1. Immunology and Inflammation

    The extra-islet pancreas supports autoimmunity in human type 1 diabetes

    Graham L Barlow, Christian M Schürch ... Paul L Bollyky
    A high-parameter, spatial analysis of the pancreata of individuals with type 1 diabetes reveals specific patterns of immune infiltration into islets of Langerhans, coordinated with changes in the surrounding tissue.
    1. Immunology and Inflammation

    Coevolutionary interplay: Helminths-trained immunity and its impact on the rise of inflammatory diseases

    Eugenio Antonio Carrera Silva, Juliana Puyssegur, Andrea Emilse Errasti
    Deciphering the gut biome's, including helminths', influence on human trained immunity will unlock novel immunotherapies harnessing the immune reprogramming potential of their secreted factors and extracellular vesicles.
    1. Genetics and Genomics

    Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life

    Irina Lazar-Contes, Rodrigo G Arzate-Mejia ... Isabelle M Mansuy
    Developmental transitions in mouse spermatogonial cells reveal extensive chromatin remodeling, stage-specific gene expression, and newly accessible transposable elements with regulatory potential.
    1. Neuroscience

    An anatomical and physiological basis for flexible coincidence detection in the auditory system

    Lauren J Kreeger, Suraj Honnuraiah ... Lisa Goodrich
    In the mammalian auditory brainstem, inhibitory inputs onto octopus cell dendrites enhance coincidence detection computations and support precise yet flexible temporal processing for rapid sound onsets and frequency modulations.
    1. Medicine

    Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa

    Hyun Beom Song, Laura Campello ... Anand Swaroop
    Reserpine, previously identified through high-throughput screening in CEP290 retinal degeneration models, enhances photoreceptor survival in P23H rhodopsin retinal degeneration models, particularly in female rats, indicating its gene-agnostic and sex-specific effectiveness.