Browse our latest research

Page 10 of 1,896
    1. Immunology and Inflammation

    Simplifying principles underlying the highly complex peptide motif of the promiscuous chicken MHC class I molecule, BF2*21:01

    Michael Harrison, Paul E Chappell ... Jim Kaufman
    Infectious disease resistance in chickens strongly depends on a genomic region called the MHC, and the rules governing pathogen peptide presentation for a key MHC molecule may aid vaccine development.
    1. Neuroscience

    Behavioural and neurogenetic evidence for emotion primitives in the fruit fly Drosophila from an open field test

    Yi Lueningschroer-Wang, Emilia Derksen ... Christian Wegener
    Wall-following and total walking activity in a behavioural assay can serve as indicators of emotional valence and arousal and provide evidence for the presence of emotion primitives in fruit flies.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Quantifying microbial fitness in high-throughput experiments

    Justus Wilhelm Fink, Michael Manhart
    The choice of fitness metric is crucial in microbial ecology—commonly chosen metrics lead to different results that may affect the conclusions from pairwise competition assays and high-throughput genetic screens.
    1. Neuroscience

    Psilocybin asymmetrically modulates outcome-based choice and cortical processing under uncertainty

    David Jacobs, Alejandro Torrado Pacheco ... Bita Moghaddam
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    WNK-SPAK/OSR1 signaling pathway facilitates ictal activity via reduced neuronal chloride extrusion rate

    Volodymyr I Dzhala, Fu Hung Shiu ... Kevin J Staley
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Preferential formation of NUP98::KDM5A condensates at specific H3K4me3-rich loci drives leukemogenic gene expression

    Augusto Berrocal, Jonathan E Sandoval ... Bo Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    A neural mechanism for compositional structure transfer in humans

    Lennart Luettgau, Nan Chen ... Raymond J Dolan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Glutamate receptor composition at Drosophila neuromuscular junctions depends on developmental stage and muscle identity

    Anne Sustar, Chengjie Qiu ... John C Tuthill
    Diverse combinations of glutamate receptor subunits are expressed across developmental stages and even between adjacent muscles in adult Drosophila.
    1. Neuroscience

    Oxytocin neurons signal state-dependent transitions from rest to thermogenesis and behavioral arousal

    Morgane Vandendoren, Jason G Landen ... Adam Nelson
    Oxytocin neurons couple physiological warming to behavioral arousal, revealing a homeostatic mechanism that coordinates transitions between low- and high-energy states.
    1. Neuroscience

    Compensation of hyperexcitability with simulation-based inference

    Daniel Müller-Komorowska, Tomoki Fukai
    Simulation-based inference predicts putative circuit mechanisms of hyperexcitability in a phenomenological microcircuit simulator with more than 30 free intrinsic and synaptic parameters.