Physiology

Physiology

eLife reviews research that reveals the mechanisms driving physiological processes across all levels of organisation. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Physiology
    2. Structural Biology and Molecular Biophysics

    Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

    Giulia Arecchi, Marica Dente ... Chiara Tesi
    Label-free optical imaging provides a direct readout of relaxed myosin conformational states in skeletal and cardiac muscle.
    1. Genetics and Genomics
    2. Physiology

    mTOR regulates longevity through a bile-acid like hormonal mechanism and DHS-26/DHRS1

    Klara Schilling, Alex Zaufel ... Adam Antebi
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Physiology

    Reproductive experience promotes permanent body growth independently of growth hormone

    Gabriel O de Souza, Willian O dos Santos ... Jose Donato
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Physiology

    Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

    Fangluo Chen, Muzna Saqib ... G William Wong
    Gene dosage imbalance due to the triplication of human chromosome 21 gene orthologs impairs whole-body glucose and lipid metabolism by disrupting homeostatic processes across major metabolic tissues.
    1. Cell Biology
    2. Physiology

    Aging induced structural alterations in SR-Mitochondria interaction in skeletal muscle: Emerging insights

    Unmod Senapati, Barsha Priyadarshini Kar ... Naresh Chandra Bal
    Not revised
    Reviewed Preprint v1
    1. Physiology

    Optical single-channel recording of CRAC channels with HaloTag and a Ca2+-sensitive ligand

    Harsharan Dhillon, Richard S Lewis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Neuroscience
    2. Physiology

    Exercise-Induced Hypoalgesia Following High- vs. Low-Intensity Aerobic Exercise in Fit Females

    Janne I Nold, Tahmine Fadai ... Christian Büchel
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cell Biology
    2. Physiology

    Roles of G-protein coupled receptors and mechanosensitive ion channels in pressure-induced chronotropy of lymphatic vessels

    Michael J Davis, Hae Jin Kim ... Scott D Zawieja
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    • Incomplete
    1. Cell Biology
    2. Physiology

    Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells

    Scott D Zawieja, Grace A Pea ... Michael J Davis
    Lymphatic muscle cells, but not CD34+ adventitial cells, exhibited pacemaker behaviors including pressure-dependent depolarization, pressure-dependent calcium mobilization during diastole, and propagated contraction waves induced by focal, optogenetic depolarization via channel rhodopsin2.
    1. Cell Biology
    2. Physiology

    Lymphatic System: Closing in on pacemaker cells

    Pin-Ji Lei, Timothy P Padera
    Lymphatic muscle cells orchestrate the contraction of collecting lymphatic vessels in mice.
    Version of Record
    Insight
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Senior editors

  1. Qiang Cui
    Boston University, United States
  2. John Huguenard
    Stanford University School of Medicine, United States
  3. Satyajit Rath
    National Institute of Immunology, New Delhi, India
  4. See more editors