Physiology

Physiology

eLife reviews research that reveals the mechanisms driving physiological processes across all levels of organisation. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Neuroscience
    2. Physiology

    Fitness level, but not sex, affects exercise-induced pain modulation

    Janne Ina Nold, Tahmine Fadai ... Christian Büchel
    Physical fitness may explain individual variability in exercise-related pain modulation, particularly for heat pain while sex may not substantially influence these responses across conditions.
    1. Cell Biology
    2. Physiology

    Mechanosensory Physiology: Lymphatic vessels under pressure

    Asser F Bedair, Osama F Harraz
    Lymphatic vessels beat faster as they fill with fluid through a chain of calcium signaling, though the first pressure sensor remains a mystery.
    Version of Record
    Insight
    1. Cell Biology
    2. Physiology

    Primary cilia in the growing limb are preferentially orientated, uncoupled from centriolar position

    Theana Johnson, Swati Midha ... Angus KT Wann
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Genetics and Genomics
    2. Physiology

    Steroid Signaling: A hormonal message for a longer life

    Kyle Feola, Peter M Douglas
    The steroid hormone dafachronic acid may carry the effects of reduced mTOR activity between tissues to coordinate metabolism and longevity across the body.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Physiology

    RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation in Caenorhabditis elegans

    Chung-Chih Liu, Nicolas Seban, Supriya Srinivasan
    Specialized anterior intestinal cells in Caenorhabditis elegans act as sentinels, regulating pathogen responses and linking food availability to gut peptide secretion through pyruvate metabolism.
    1. Physiology

    Reproductive experience promotes permanent body growth independently of growth hormone

    Gabriel O de Souza, Willian O dos Santos ... Jose Donato
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Physiology

    NK2R signaling governs intestinal lipid mobilization and mucosal inflammation

    Pedro A Perez, Chung-Chih Liu ... Supriya Srinivasan
    NK2R is a molecular switch linking tachykinin signaling to intestinal lipid handling, mucosal inflammation and gut microbiota, positioning NK2R-targeted peptide therapeutics for cardiometabolic and inflammatory bowel diseases.
    1. Physiology

    Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage in Drosophila females

    Puja Biswas, Elizabeth J Rideout
    Sex-specific regulation of enteroendocrine hormones shapes energy storage differently in male and female flies.
    1. Cell Biology
    2. Physiology

    Ion channels and GPCR requirements for pressure-induced lymphatic chronotropy: Evidence for a Gαq/11-IP3R1-ANO1 pacemaking axis

    Michael J Davis, Hae Jin Kim ... Scott D Zawieja
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience
    2. Physiology

    The P2X7 receptor is an intermediate in the retinoic acid-signaling pathway that induces neuronal remodeling in retinitis pigmentosa

    Michael Telias, Leonor Afrima ... Richard H Kramer
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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Senior editors

  1. Lu Chen
    Stanford University, United States
  2. Qiang Cui
    Boston University, United States
  3. Volker Dötsch
    Goethe University, Germany
  4. See more editors