Physiology

Physiology

eLife reviews research that reveals the mechanisms driving physiological processes across all levels of organisation. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Physiology

    Reproductive experience promotes permanent body growth independently of growth hormone

    Gabriel O de Souza, Willian O dos Santos ... Jose Donato
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Physiology

    NK2R signaling governs intestinal lipid mobilization and mucosal inflammation

    Pedro A Perez, Chung-Chih Liu ... Supriya Srinivasan
    NK2R is a molecular switch linking tachykinin signaling to intestinal lipid handling, mucosal inflammation and gut microbiota, positioning NK2R-targeted peptide therapeutics for cardiometabolic and inflammatory bowel diseases.
    1. Physiology

    Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage in Drosophila females

    Puja Biswas, Elizabeth J Rideout
    Sex-specific regulation of enteroendocrine hormones shapes energy storage differently in male and female flies.
    1. Cell Biology
    2. Physiology

    Ion channels and GPCR requirements for pressure-induced lymphatic chronotropy: Evidence for a Gαq/11-IP3R1-ANO1 pacemaking axis

    Michael J Davis, Hae Jin Kim ... Scott D Zawieja
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience
    2. Physiology

    The P2X7 receptor is an intermediate in the retinoic acid-signaling pathway that induces neuronal remodeling in retinitis pigmentosa

    Michael Telias, Leonor Afrima ... Richard H Kramer
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Physiology
    2. Structural Biology and Molecular Biophysics

    Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

    Giulia Arecchi, Marica Dente ... Chiara Tesi
    Label-free optical imaging provides a direct readout of relaxed myosin conformational states in skeletal and cardiac muscle.
    1. Genetics and Genomics
    2. Physiology

    mTOR regulates longevity through a bile-acid like hormonal mechanism and DHS-26/DHRS1

    Klara Schilling, Alex Zaufel ... Adam Antebi
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Chromosomes and Gene Expression
    2. Physiology

    Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

    Fangluo Chen, Muzna Saqib ... G William Wong
    Gene dosage imbalance due to the triplication of human chromosome 21 gene orthologs impairs whole-body glucose and lipid metabolism by disrupting homeostatic processes across major metabolic tissues.
    1. Cell Biology
    2. Physiology

    Aging induced structural alterations in SR-Mitochondria interaction in skeletal muscle: Emerging insights

    Unmod Senapati, Barsha Priyadarshini Kar ... Naresh Chandra Bal
    Not revised
    Reviewed Preprint v1
    1. Physiology

    Optical single-channel recording of CRAC channels with HaloTag and a Ca2+-sensitive ligand

    Harsharan Dhillon, Richard S Lewis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
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Senior editors

  1. Qiang Cui
    Boston University, United States
  2. Volker Dötsch
    Goethe University, Germany
  3. Satyajit Rath
    National Institute of Immunology, New Delhi, India
  4. See more editors