Physiology

Physiology

eLife reviews research that reveals the mechanisms driving physiological processes across all levels of organisation. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Physiology

    Roles of G-protein coupled receptors and mechanosensitive ion channels in pressure-induced chronotropy of lymphatic vessels

    Michael J Davis, Hae Jin Kim ... Scott D Zawieja
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    • Incomplete
    1. Cell Biology
    2. Physiology

    Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells

    Scott D Zawieja, Grace A Pea ... Michael J Davis
    Lymphatic muscle cells, but not CD34+ adventitial cells, exhibited pacemaker behaviors including pressure-dependent depolarization, pressure-dependent calcium mobilization during diastole, and propagated contraction waves induced by focal, optogenetic depolarization via channel rhodopsin2.
    1. Cell Biology
    2. Physiology

    Lymphatic System: Closing in on pacemaker cells

    Pin-Ji Lei, Timothy P Padera
    Lymphatic muscle cells orchestrate the contraction of collecting lymphatic vessels in mice.
    Version of Record
    Insight
    1. Structural Biology and Molecular Biophysics
    2. Physiology

    Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

    Giulia Arecchi, Marica Dente ... Chiara Tesi
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience
    2. Physiology

    TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension

    Christopher Nass Rudzitis, Monika Lakk ... David Krizaj
    The TRPV4 channel was identified as an obligatory regulator of physiological and pathological increases in intraocular pressure.
    1. Medicine
    2. Physiology

    Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

    Yanling Huang, Haocong Mo ... Geyang Xu
    Experimental results suggest a previously unknown regulatory mechanism for GLP-1 production in L cells, which could offer new insights into diabetes treatments.
    1. Biochemistry and Chemical Biology
    2. Physiology

    SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption

    Yoshihisa Mimura, Tomoya Yasujima ... Hiroaki Yuasa
    SLC35G1 is the first highly chloride-sensitive transporter localized on the basolateral membrane of intestinal epithelial cells, responsible for citrate absorption.
    Version of Record
    Short Report
    • Important
    • Convincing

Senior editors

  1. Lu Chen
    Stanford University, United States
  2. Qiang Cui
    Boston University, United States
  3. Dolores Shoback
    University of California, San Francisco, United States
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