Physiology

Latest articles

1. 1. Cell Biology
   2. Physiology

   Roles of G-protein coupled receptors and mechanosensitive ion channels in pressure-induced chronotropy of lymphatic vessels

   Michael J Davis, Hae Jin Kim ... Scott D Zawieja
2. 1. Cell Biology
   2. Physiology

   Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells

   Scott D Zawieja, Grace A Pea ... Michael J Davis

   Lymphatic muscle cells, but not CD34⁺ adventitial cells, exhibited pacemaker behaviors including pressure-dependent depolarization, pressure-dependent calcium mobilization during diastole, and propagated contraction waves induced by focal, optogenetic depolarization via channel rhodopsin2.
3. 1. Cell Biology
   2. Physiology

   Lymphatic System: Closing in on pacemaker cells

   Pin-Ji Lei, Timothy P Padera

   Lymphatic muscle cells orchestrate the contraction of collecting lymphatic vessels in mice.
4. 1. Structural Biology and Molecular Biophysics
   2. Physiology

   Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

   Giulia Arecchi, Marica Dente ... Chiara Tesi
5. 1. Neuroscience
   2. Physiology

   TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension

   Christopher Nass Rudzitis, Monika Lakk ... David Krizaj

   The TRPV4 channel was identified as an obligatory regulator of physiological and pathological increases in intraocular pressure.
6. 1. Medicine
   2. Physiology

   Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

   Yanling Huang, Haocong Mo ... Geyang Xu

   Experimental results suggest a previously unknown regulatory mechanism for GLP-1 production in L cells, which could offer new insights into diabetes treatments.
7. 1. Biochemistry and Chemical Biology
   2. Physiology

   SLC35G1 is a highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption

   Yoshihisa Mimura, Tomoya Yasujima ... Hiroaki Yuasa

   SLC35G1 is the first highly chloride-sensitive transporter localized on the basolateral membrane of intestinal epithelial cells, responsible for citrate absorption.