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    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
    Predictive pharmacology based on behavioural fingerprinting can identify druggable pathways that are altered or renormalized in zebrafish larvae that harbor mutations in early and late-onset Alzheimer's disease risk genes.
    1. Biochemistry and Chemical Biology

    Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

    Gabriella O Estevam, Edmond Linossi ... James S Fraser
    A deep mutational scan of MET kinase domain variants reveals resistance and sensitizing mutations for 11 inhibitors, providing a mutation-specific reference for precision therapies and drug development.
    1. Neuroscience

    Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions

    Akiko Ueno, Konan Sakuta ... Chieko Koike
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis

    Adam Kim, Megan R McMullen ... Srinivasan Dasarathy
    Not revised
    Reviewed Preprint v1
    • Incomplete
    1. Neuroscience

    Novel and optimized mouse behavior enabled by fully autonomous HABITS: Home-cage Assisted Behavioral Innovation and Testing System

    Bowen Yu, Penghai Li ... Yaoyao Hao
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Brain-Cognitive Gaps in relation to Dopamine and Health-related Factors: Insights from AI-Driven Functional Connectome Predictions

    Morteza Esmaeili, Erin Beate Bjørkeli ... Alireza Salami
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Genetics and Genomics
    2. Neuroscience

    Oxytocin receptor controls promiscuity and development in prairie voles

    Ruchira Sharma, Kristen M Berendzen ... Devanand S Manoli
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics

    fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans

    Angela M Tuckowski, Safa Beydoun ... Scott F Leiser
    fmo-4 slows aging downstream of dietary restriction and mTOR and regulates calcium-mediated signaling in the hypodermis.
    1. Neuroscience

    Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms

    Christopher Bell, Lukas Kilo ... Stefanie Ryglewski
    Mutually exclusive splicing of two exon pairs of the only Drosophila Cav2 homolog cacophony mediates functional diversity of Cav2 channels in Drosophila.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    T3SS translocon induces pyroptosis by direct interaction with NLRC4/NAIP inflammasome

    Yan Zhao, Hanshuo Zhu ... Li Sun
    T3SS translocon induces NLRC4-mediated cell death via a conserved C-terminal region shared by many T3SS-positive bacterial pathogens.
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