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    1. Cancer Biology

    Acquired resistance to sotorasib in KRASG12C mutant NSCLC is vulnerable to PI3K-mTOR pathway inhibition mediated by 4E-BP1, a regulator of cap-dependent translation

    Ismail M Meraz, Shuhong Wu ... Jack A Roth
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Ecology

    Geomagnetic and visual cues guide seasonal migratory orientation in the nocturnal fall armyworm, the world’s most invasive insect

    Yi-Bo Ma, Guijun Wan ... Gao Hu
    Behavioral evidence demonstrates that geomagnetic and visual cues are integrated to guide nocturnal migratory insects.
    1. Microbiology and Infectious Disease

    Global transcription factors analyses reveal hierarchy and synergism of regulatory networks and master virulence regulators in Pseudomonas aeruginosa

    Jiadai Huang, Yue Sun ... Xin Deng
    Systematic ChIP-seq profiling of 172 transcription factors in Pseudomonas aeruginosa reveals a hierarchical regulatory architecture governing virulence and establishes a searchable database to guide antimicrobial drug discovery.
    1. Immunology and Inflammation

    Heat shock factor regulation of antimicrobial peptides expression suggests a conserved defense mechanism induced by febrile temperature in arthropods

    Bang Xiao, Shihan Chen ... Chaozheng Li
    Febrile temperatures enhance antiviral immunity through heat shock factor-dependent antimicrobial peptides across arthropods.
    1. Neuroscience

    Audiovisual congruency drives confidence in presence and absence

    Perrine Porte, Matan Mazor ... Louise Goupil
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Gene specificity landscapes for comparative transcriptomic analysis across tissues, cell types, and species

    Erik Bot, Jose Davila-Velderrain
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Long-range neural pathways for octopus chemotactile processing revealed from periphery-to-brain by centimeter-field microCT

    Andrew Sugarman, Daniel Vanselow ... Keith C Cheng
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Cross-Species BAC Transgenesis Reveals Long-Range Regulation Drives Variation in Brain Oxytocin Receptor Expression and Social Behaviors

    Mina Tsukamoto, Luis AE Nagai ... Qi Zhang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Ecology
    2. Neuroscience

    New idtracker.ai rethinks multi-animal tracking as a representation learning problem to increase accuracy and reduce tracking time

    Jordi Torrents, Tiago Costa, Gonzalo de Polavieja
    Identification of each animal in a collective becomes possible even when individuals are never all visible simultaneously, enabling faster and more accurate analysis of collective behavior.
    1. Developmental Biology

    Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitors

    Fengzhu Xiong, Andrea R Tentner ... Sean G Tsung-Megason
    Comparing signaling response profiles and fate outcomes in single cells reveals logic and limits of signal interpretation.
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