Christin Krause, Jan H Britsemmer ... Henriette Kirchner
The liver microRNA transcriptome of humans with type 2 diabetes and obesity is analyzed for the first time and compared with diet-induced obesity in mice.
Noémie te Rietmolen, Manuel R Mercier ... Daniele Schön
The neural response to natural speech and music processing is mostly shared between the domains, with additional evidence for selectivity in distributed (i.e. not regional) and frequency-specific neural activity.
Adaptation within a continuous attractor neural network explains theta phase precession and procession, providing insight into the neural mechanism of theta phase coding in the hippocampus.
N Suhas Jagannathan, Javier Yu Peng Koh ... Lisa Tucker-Kellogg
To investigate why bats are long-lived and cancer-resistant, multi-omic data from bat and human cells was analyzed using computational flux modeling, suggesting dysregulation of succinate-fumarate dynamics and an ischemic-like basal metabolism in bat cells.
Sara Ibañez, Nilapratim Sengupta ... Christina M Weaver
Biologically plausible levels of myelin dystrophy induce substantial working memory impairment in a computational model of brain aging across two spatial and temporal scales.
Katarzyna Marta Zoltowska, Utpal Das ... Lucía Chávez-Gutiérrez
A novel Aβ-driven inhibitory mechanism on γ-secretases, which leads to substrate accumulation and reduced release of products, contributes to neurotoxicity by impairing γ-secretase signaling and might operate in Alzheimer’s disease.
