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    1. Cell Biology
    2. Microbiology and Infectious Disease

    Cell cycle dependent variation in endocytosis drives phenotypic diversity in M. tuberculosis

    Neeraja Subhash, Sandhya Krishnan Radhakrishnan ... Varadharajan Sundaramurthy
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics
    2. Medicine

    Single-cell transcriptome-wide Mendelian randomization and colocalization analyses reveal immune-cell-specific mechanisms and actionable drug targets in prostate cancer

    Yanggang Hong, Yi Wang ... Jiajun Li
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Whisker-based pre-neuronal and peripheral encoding of surface stickiness

    Isis S Wyche, Michaela A O’Neil, Daniel H O’Connor
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Solid
    1. Neuroscience

    Human and mouse cerebellar inhibitory circuits in dystonic crisis and their modulation with therapeutic stimulation

    Alejandro G Rey Hipolito, Michael P Dew ... Roy V Sillitoe
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation

    Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

    Peter Georgiev, Sheila Johnson ... Arlene H Sharpe
    A comprehensive investigation of extracellular asparagine utilization highlights its role as a critical regulator of murine CD4+ T cell activation, differentiation, and function.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Celldetective, an AI-enhanced image analysis tool for unraveling dynamic cell interactions

    Rémy Torro, Beatriz Díaz-Bello ... Laurent Limozin
    Celldetective is an open-source software integrating segmentation, tracking, and event detection to perform high-throughput end-to-end study of dynamic cell interactions, without requiring coding skills, demonstrated on microscopy immunological assays.
    1. Biochemistry and Chemical Biology

    Dynamic assembly of malate dehydrogenase–citrate synthase multienzyme complex in the mitochondria

    Joy Omini, Inga Krassovskaya ... Toshihiro Obata
    The yeast mitochondrial malate dehydrogenase–citrate synthase metabolon is a dynamic multienzyme complex that continuously assembles and disassembles in response to respiratory activity, mitochondrial matrix pH, and substrate abundances.
    1. Structural Biology and Molecular Biophysics

    Lenacapavir-induced lattice hyperstabilization is central to HIV-1 capsid failure at the nuclear pore complex and in the cytoplasm

    Arpa Hudait, Ryan C Burdick ... Gregory A Voth
    Lenacapavir disrupts HIV-1 capsid elasticity, inducing mechanical rupture at the nuclear pore, highlighting that altering viral material properties can be a viable antiviral drug design strategy.
    1. Immunology and Inflammation

    TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy

    Josselyn D Barahona, Liping Yang ... Wayne M Yokoyama
    Uterine natural killer (NK) cells require TGF-β to be derived from conventional NK cells and contribute to successful pregnancy.
    1. Neuroscience

    Visual working memory guides attention rhythmically in humans

    Jiachen Lu, Yaochun Cai, Xilin Zhang
    Working memory alternates between remembered items in a rhythmic theta cycle.
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