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    1. Microbiology and Infectious Disease

    Reactive oxygen detoxification contributes to Mycobacterium abscessus antibiotic survival

    Nicholas A Bates, Ronald Rodriguez ... Bennett H Penn
    Antibiotics that inhibit translation cause a burst in reactive oxygen species, and these must be detoxified by factors such as KatG for cells to survive.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The adaptive landscapes of three global Escherichia coli transcriptional regulators

    Cauã Antunes Westmann, Leander Goldbach, Andreas Wagner
    Across three global Escherichia coli regulators, identical starting sequences can evolve toward many distinct strong-binding peaks, with chance, historical contingency, and evolutionary bias shaping which outcomes prevail.
    1. Developmental Biology

    A genetic screen reveals dosage-sensitive effects of ASD genes and identifies domino as a regulator of synaptic and behavioral phenotypes

    Ellen Stirtz, Zachary B Madaj ... Adelheid Lempradl
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Structural basis for site-specific histone H3 acetylation-dependent regulation of RNAPII transcription through nucleosomes

    Takumi Oishi, Suguru Hatazawa ... Hitoshi Kurumizaka
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    A stable cryogenic fluorescence microscope for correlative super-resolution light and electron microscopy

    Soheil Mojiri, Joseph M Dobbs ... Jonas Ries
    Not revised
    Reviewed Preprint v1
    • Useful
    • Compelling
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Germline-somatic residue synergy reshapes antibody encounter-state pathways to enhance HIV-1 recognition

    Sangita Kachhap, Yishak Bililign ... Rory Henderson
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Distinct cell-type contributions and network topography of theta-nested gamma oscillations in the medial entorhinal cortex

    Brandon Williams, Riya Dahal ... John A White
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Developmental Biology
    2. Genetics and Genomics

    Flexible and high-throughput simultaneous profiling of gene expression and chromatin accessibility in single cells

    Volker Soltys, Moritz A Peters ... Yingguang Frank Chan
    A single-cell multiomic technique measuring both transcription and chromatin accessibility in the same cell.
    1. Neuroscience

    Organization of circuits linking descending input to motor output in the Drosophila Male Adult Nerve Cord connectome

    Han SJ Cheong, Katharina Eichler ... Gwyneth M Card
    Circuit analyses of synaptic connectivity in networks connecting descending and motor neurons in the Drosophila Male Adult Nerve Cord connectome reveal the modular network organization of descending to motor pathways.
    1. Neuroscience

    Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state

    Kexin Qi, Yuming Chai ... Quan Wen
    Serotonin promotes a sleep-independent quiescent state through selective modulation of motor neural population dynamics.
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