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    1. Physiology

    Optical single-channel recording of CRAC channels with HaloTag and a Ca2+-sensitive ligand

    Harsharan Dhillon, Richard S Lewis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Neuroscience

    Layer-specific spatiotemporal dynamics of feedforward and feedback in human visual object perception

    Tony Carricarte, Siying Xie ... Radoslaw M Cichy
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    • Solid
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies

    Yi Lin, Benjamin Liou ... Ying Sun
    Human midbrain organoids provide a foundation for the development of patient-specific preclinical models to support personalized therapeutic approaches and enable evaluation of disease mechanisms and therapeutic strategies in human context.
    1. Structural Biology and Molecular Biophysics

    Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling

    Nevin K Zacharia, Stefanie Kuhns ... Esben Lorentzen
    The IFT172 C-terminus bridges IFT-A and IFT-B complexes through mutually exclusive interactions with IFT140 and IFT144, and harbors a U-box-like domain linking intraflagellar transport to ubiquitin-dependent ciliary signaling.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    From multiplicity of infection to force of infection in sparsely sampled high-transmission Plasmodium falciparum populations

    Qi Zhan, Kathryn E Tiedje ... Mercedes Pascual
    Queuing theory links multiplicity of infection (MOI) to force of infection (FOI), enabling the estimation of transmission intensity for falciparum malaria (and other infectious diseases) from sparsely sampled surveys.
    1. Neuroscience

    Layer-specific wide-field calcium imaging of neocortical activity

    Dayra A Lorenzo, Yasir Gallero-Salas ... Fritjof Helmchen
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology

    Identification of nuclear pore proteins at plasmodesmata: potential role in intercellular transport?

    T Moritz Schladt, Manuel Miras ... Wolf B Frommer
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Solid
    1. Microbiology and Infectious Disease

    Apparent cooperativity between human CMV virions introduces errors in conventional methods of calculating multiplicity of infection

    Christopher Peterson, Joshua Miller ... Vitaly V Ganusov
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology
    2. Neuroscience

    Transcriptional profiling of extraocular motor neurons reveals sim1a as a candidate strabismus-related gene

    Emily Gershowitz, Kyla Rose Hamling ... David Schoppik
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Dopamine ramps as a normative consequence of dual-process control

    Luke Priestley, Thomas Akam
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
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