Multimodal stacking of MRI‑based markers of cognition reveals a shared brain architecture that links cognitive performance with mental health, explaining nearly half of their observed association.
The dynamic internal fluidity of nuclear MORC2 condensates, rather than their mere assembly, is strictly required for transcriptional regulation and is selectively disrupted by neuropathy-linked mutations.
Sofia Lövestam, Jane L Wagstaff ... Sjors HW Scheres
Phosphomimetic mutations allow the assembly of full-length recombinant tau into Alzheimer's paired helical filaments by disrupting intramolecular contacts between its ordered core and fuzzy coat.
EXOC6A cooperates with myosin-Va to regulate vesicle trafficking and membrane remodeling during ciliogenesis, enabling ciliary vesicle maturation, transition zone assembly, and proper delivery of ciliary membrane proteins.
