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Primordial cardiomyocytes play an essential role in myocardial morphogenesis and coronary vascularization, but not in adult zebrafish heart regeneration.

A genome-wide RNA interference screen identified cellular processes that modulate the phase separation of a TDP-43 mutant, providing a framework for dissecting the link between its phase behavior and disease-associated aggregation.

An actin-nucleation-dependent assembly of the axonal membrane skeleton reveals that βII-spectrin gap-and-patch patterns in human motor neurons represent an intermediate stage of cytoskeletal maturation.

Layer 6b neurons shape state-dependent brain rhythms and responses to orexin, revealing an underappreciated cortical mechanism that may help explain disrupted sleep-wake regulation in neurodevelopmental and psychiatric disorders more broadly.

Single-cell observations refute the expectation that centrosome positioning is critical for epithelial cell polarization while showing that proper positioning enhances polarization efficiency.