Browse our latest research

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    1. Cancer Biology

    Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

    Kyle Spinler, Michael Hamilton ... Tannishtha Reya
    A naturally occurring Musashi2 genetic translocation reported to occur in blast crisis chronic myelogenous leukemia patients can act as an oncogene and drive myeloid leukemia.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Atypical collective oscillatory activity in cardiac tissue uncovered by optogenetics

    Alexander S Teplenin, Nina N Kudryashova ... Tim De Coster
    Collective frequency-selective resonance in depolarised cardiac tissue enables reversible switching between quiescent and ectopic oscillations through hidden bi-stability, which is shaped by light intensity, illuminated area, and pacing frequency.
    1. Immunology and Inflammation

    A co-evolutionary perspective on humans and Mycobacterium tuberculosis in the era of systems biology

    Michaela T Reichmann, Liku B Tezera ... Paul T Elkington
    The deep evolutionary relationship between humans and Mycobacterium tuberculosis suggests latent infection may confer benefit, with important consequences for investigating and interpreting host–pathogen interactions.
    1. Biochemistry and Chemical Biology

    Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD

    Jia He, Bo Chen ... Zhao Shan
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Microbiology and Infectious Disease

    The PPE2 protein of Mycobacterium tuberculosis is responsible for the development of hyperglycemia and insulin resistance during tuberculosis

    Manoj Kumar Bisht, Vandana Maurya ... Sangita Mukhopadhyay
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Plant Biology

    Rice stripe virus utilizes a Laodelphax striatellus salivary carbonic anhydrase to facilitate plant infection by direct molecular interaction

    Jing Zhao, Xiangyi Meng ... Lili Zhang
    Planthopper salivary carbonic anhydrase enhances a plant β-1,3-glucanase to suppress callose deposition, facilitating early viral establishment of rice stripe virus.
    1. Neuroscience

    Neural coding of multiple motion speeds in visual cortical area MT

    Xin Huang, Bikalpa Ghimire ... Steven Wiesner
    Neuronal responses in cortical area MT to two speeds show a robust bias toward the faster speed when stimulus speeds are slow, which could benefit figure-ground segregation in natural scenes.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with nuclear speckles

    Chiara Tomasini, Celine Cuche ... Francesca Di Nunzio
    HIV hijacks SRRM2 to enlarge nuclear speckles, stabilizing CPSF6 puncta and promoting efficient viral replication.
    1. Neuroscience

    Dependence of contextual modulation in macaque V1 on interlaminar signal flow

    Shude Zhu, Yu Jin Oh ... Tirin Moore
    Interactions between neurons across cortical layers reflect the balance of feedforward and feedback inputs.
    1. Microbiology and Infectious Disease

    Heterogeneity of genetic sequence within quasi-species of influenza virus revealed by single-molecule sequencing

    Kenji Tamao, Hiroyuki Noji, Kazuhito Tabata
    High-accuracy single-molecule unique molecular identifier sequencing reveals non-random, biologically driven mutation heterogeneity within influenza quasi-species, enabling precise profiling of intra-host viral evolutionary potential.