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    1. Chromosomes and Gene Expression

    Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites

    Yatendra Kumar, Dipta Sengupta ... Wendy A Bickmore
    Acetylation of histone H3 at the nucleosome surface is associated with destabilised nucleosomes and is a useful new functional genomics mark for identifying regulatory regions of the mammalian genome.
    1. Computational and Systems Biology

    Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage

    Zhiwei Huang, Songhao Luo ... Jiajun Zhang
    DNA damage reshapes genome-wide transcriptional bursting, with distinct burst size and frequency programs associated with differentiation, apoptosis, and survival decisions.
    1. Cell Biology

    SLC4A1 mutations that cause distal renal tubular acidosis alter cytoplasmic pH and cellular autophagy

    Grace Essuman, Midhat Rizvi ... Emmanuelle Cordat
    Distal renal tubular acidosis induced by some SLC4A1 variants is characterized by cytosolic pH alkalization, reduced ATP synthesis and defective autophagy degradative flux.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Contractile peri-nuclear actomyosin network repositions peripheral and polar chromosomes to promote early kinetochore–microtubule interactions

    Nooshin Sheidaei, John K Eykelenboom ... Tomoyuki U Tanaka
    Not revised
    Reviewed Preprint v1
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    1. Developmental Biology
    2. Genetics and Genomics

    Flexible and high-throughput simultaneous profiling of gene expression and chromatin accessibility in single cells

    Volker Soltys, Moritz Peters ... Yingguang Frank Chan
    Not revised
    Reviewed Preprint v1
    • Useful
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    1. Evolutionary Biology
    2. Neuroscience

    Toward neuroanatomical and cognitive foundations of macaque social tolerance grades

    Sarah Silvere, Julien Lamy ... Sebastien Ballesta
    Macaque’s social tolerance grades, through its underlying cognitive demands, shape subcortical structures volumes.
    1. Biochemistry and Chemical Biology

    Intracellular expression of a fluorogenic DNA aptamer using retron Eco2

    Mahesh A Vibhute, Corbin Machatzke ... Hannes Mutschler
    Structure-guided engineering of a bacterial retron enables intracellular production of a light-up DNA aptamer whose purified DNA retains dye-activated fluorescence, establishing retrons as a scalable route to cellular aptamer synthesis.
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    Short Report
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    1. Medicine

    Sperm motility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA

    Charline Vilpreux, Paul Fourquin ... Jessica Escoffier
    Naked mRNA administration in the testes rescues sperm function, demonstrating a potential therapeutic approach for genetic male infertility.
    1. Neuroscience

    Dissociable dynamic effects of expectation during statistical learning

    Hannah H McDermott, Federico de Martino ... Ryszard Auksztulewicz
    Neural responses during statistical learning reveal dissociable dynamic effects of expectation, supporting the opposing process theory within trials while demonstrating contrasting effects across trials.
    1. Neuroscience

    Comprehensive Neural Representations of Naturalistic Stimuli through Multimodal Deep Learning

    Mingxue Fu, Guoqiu Chen ... Yin Wang
    Revised
    Reviewed Preprint v2
    Updated
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