Carolyne Jie Huang, Samuel Pawel ... Rachel Heyard
A simulation study shows that metrics suggested to assess replication studies are useful in the translation context, but researchers need to clarify their translation goals a priori.
Separate prefrontal output channels preferentially track anxiety, exploration, and social preference, revealing how emotional context is organized into adaptive behavior.
LRRK2 couples brain-derived neurotrophic factor (BDNF) signaling to synaptic actin remodeling, defining a novel mechanism of LRRK2 synaptic function and highlighting early, targetable pathways in Parkinson’s disease.
The genomic response of endothelial cells to hypoxia via MOA-seq transcription factor occupancy profiling identified known and novel HIF1A-associated and independent cis-regulatory elements, which defined ten distinct hypoxic kinetic clusters.
