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Proteomic analyses reveal a distinct protein signature underlying microtubule organization and regenerative asymmetries in sensory neuron axons, supported by an in vitro system replicating key features of sensory neuron biology.

An optimized cytosine base editing system for Leishmania species improves editing efficiency, reduces toxicity, and ensures stable guide expression, enabling scalable loss-of-function screening and efficient creation of functional mutants.

Methylation profiling and functional analyses reveal critical roles of DNA methylation in regulating virulence and metabolism of P. syringae.

Cell biological approaches and spatiotemporally resolved proteome profiling demonstrate that the chemokine receptor CCR7 can activate G proteins after being internalized into endosomes, from where it regulates Rac1-dependent chemotaxis.

G-quadruplexes accumulate in the brain with aging and Alzheimer's disease, suggesting a new possible mechanism of neurodegeneration.

Grid cells within an individual module show significantly more variability in grid properties than would be expected by chance, resulting in improved neural representation of animal location in the environment.

Insights into the molecular and genetic landscape underlying adaptive salinity stress responses in rice.

A liver-specific depletion of the survival motor neuron protein in a mouse model unveils a compelling and intricate connection between liver function and pancreatic abnormalities in spinal muscular atrophy.

Extremely early antiretroviral therapy during HIV-1 subtype C infection leads to faster decline in genome-intact viruses, reduced genetic complexity, and immune escape, and may enhance reservoir clearance with additional interventional strategies.