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    1. Neuroscience

    iGABASnFR2 is an improved genetically encoded protein sensor of GABA

    Ilya Kolb, Jeremy P Hasseman ... Glenn C Turner
    An improved genetically encoded GABA sensor enables the most effective direct optical measurement of inhibitory neurotransmission to date.
    1. Evolutionary Biology

    Earliest evidence of elephant butchery at Olduvai Gorge (Tanzania) reveals the evolutionary impact of early human megafaunal exploitation

    Manuel Dominguez-Rodrigo, Enrique Baquedano ... Audax Mabulla
    The discovery of the earliest direct evidence of systematic proboscidean butchery at Olduvai Gorge demonstrates that by 1.8 Ma early hominins had strategically integrated megafaunal exploitation into their subsistence systems.
    1. Developmental Biology
    2. Plant Biology

    Alternative splicing of PIF4 regulates plant development under heat stress

    María Niño-González, Benjamin Alary ... Guiomar Martín
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Evolutionary Biology

    No evidence for disassortative mating based on HLA in a small-scale, endogamous population

    Gillian L Meeks, Brooke Scelza ... Brenna M Henn
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Genetics and Genomics

    ARID5B mutations cause a neurodevelopmental syndrome with neuroinflammation episodes

    Hendrikus J van Heesbeen, Nazim Rabouhi ... Philippe M Campeau
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Dynamic RNA Polymerase compartments organize the transcription of gene clusters

    Yi-Hui Wang, Hannah L Hertz, Wen Tang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cancer Biology

    Nerve Injury-Induced Protein 2 preserves lysosomal membrane integrity to suppress ferroptosis

    Jin Zhang, Miranda Bustamante ... Xinbin Chen
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Cell Biology
    2. Genetics and Genomics

    Effects of knockdown of autophagy pathway genes on C. elegans longevity are highly condition dependent

    Kuei Ching Hsiung, Hannah Chapman ... David Gems
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration in human cancer cells

    Ravi Kumar, Simon Couly ... Ashish Lal
    Global proteomics and functional analyses reveal that p53-induced ZMAT3 suppresses mitochondrial respiration by inhibiting transcription of a hexokinase, uncovering a role for ZMAT3 in transcription.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice

    Philip MM Ruppert, Aylin S Gueller ... Jan-Wilhelm Kornfeld
    Transcriptomic profiling on liver and adipose depots reveals tissue-specific and beige-fat–convergent responses to methionine restriction and cold, providing a high-quality resource to guide combinatorial lifestyle interventions for metabolic disease research.
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