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    1. Cancer Biology

    Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis

    Patrick B Jonker, Mumina Sadullozoda ... Alexander Muir
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cell Biology
    2. Neuroscience

    A validated antibody toolbox for ALS research

    Riham Ayoubi, Emma J MacDougall ... Carl Laflamme
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Dissecting mechanisms of ligand binding and conformational changes in the glutamine-binding protein

    Zhongying Han, Sabrina Panhans ... Thorben Cordes
    A range of biophysical techniques is used in combination with computational analysis to understand whether glutamine-binding protein binds its ligand via the induced-fit or conformational selection mechanism.
    1. Cell Biology

    Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism

    Fangqing Deng, Rong Yang ... Lianbing Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology

    Mural cells protect the adult brain from hemorrhage but do not control the blood–brain barrier in developing zebrafish

    Oguzhan F Baltaci, Andrea Usseglio Gaudi ... Benjamin M Hogan
    Pericytes regulate cerebrovascular development, while vascular smooth muscle cells prevent hemorrhage and blood–brain barrier breakdown at vascular hotspots in juvenile and adult zebrafish.
    1. Immunology and Inflammation

    Beta-Glucan modulates monocyte plasticity and differentiation capacity to mitigate DSS-induced colitis

    Yinyin Lv, Yanyun Fan ... Hongzhi Xu
    Trained monocytes alleviate DSS-induced colitis via bacterial clearance and monocyte differentiation reprogramming.
    1. Evolutionary Biology
    2. Neuroscience

    Distinct evolutionary trajectories of two integration centres, the central complex and mushroom bodies, across Heliconiini butterflies

    Max S Farnworth, Yi Peng Toh ... Stephen H Montgomery
    A cognitive adaptation in Heliconius butterflies, accompanied by strikingly divergent changes in two principal insect integration centres, reveals that neural circuits can differ strongly in their propensity for evolutionary change.
    1. Chromosomes and Gene Expression

    Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes

    Dorian Besson, Sabine Vaur ... Jean-Paul Javerzat
    A conserved kinase network links nutrient sensing to chromosome segregation and gene regulation by modulating cohesin dynamics through phosphorylation.
    Version of Record
    Research Article
    • Important
    • Compelling
    • Convincing
    1. Genetics and Genomics
    2. Plant Biology

    Uncovering genetic mechanisms underlying trait variation in switchgrass using explainable artificial intelligence

    Paulo Izquierdo, Xiaoyu Weng ... Shin-Han Shiu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Examining Alzheimer’s Disease modifiable risk factors: Impact of physical activity and diet on neuroanatomy and behaviour in mouse models

    Cindy L García, Chloe Anastassiadis ... M Mallar Chakravarty
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
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