Low-level features of peripheral saccade targets are fed back to early foveal retinotopic cortex in a signal that resembles activation elicited by direct foveal presentation.
Genetic and electrophysiological studies uncover a mechanism linking a TTN missense variant to atrial fibrillation by coupling titin with potassium channel remodeling, revealing FHL2 as a modulator and therapeutic target.
Trained immunity enhances innate immune responses, yet a Western lifestyle may lead to maladaptive trained immunity and drive non-communicable diseases.
Liudmyla Arifova, Brian S MacTavish ... Douglas J Kojetin
Covalent PPARγ inhibitors that better stabilize a repressive conformation are more effective inhibitors, but structural plasticity still allows ligand cobinding by enabling a shift back to an active conformation.
Samuel J Rosen, Olivier Witteveen ... Maxwell Z Wilson
Human cells decode dynamics Wnt signals using an anti-resonant filter that suppresses intermediate-frequency inputs and is capable of redirecting developmental fate outcomes, including germ-layer specification.
