Pragnya Chakraborty, Bipan Kumar Deb ... Gaiti Hasan
Binding of the second messenger inositol 1,4,5-trisphosphate to its intracellular receptor drives interaction between the intracellular Ca2+ sensor STIM and the plasma membrane localized Ca2+ channel Orai and raises the level of store-operated Ca2+ entry in mammalian cells.
The small, highly conserved transmembrane protein disrupted in zebrafish dreammist mutants regulates the activity of the sodium-potassium pump, leading to changes in sleep behaviour.
Hui Zhen Tan, Justin JFJ Jansen ... Frank E Rheindt
Application of museomics facilitates characterization of the contribution of historical factors to genetic diversity declines in Numenius shorebirds and highlights that extinction of ecosystem-engineering megafauna may have been detrimental for open-landscape species.
Generation and validation of a new mouse strain as a tool to demonstrate the implication of p38γ/p38δ in inflammation through the regulation of the transcription factor MEF2D’s activity.
Michael T Kimble, Matthew J Johnson ... Lorraine S Symington
The long-range resection machinery is dispensable for homologous recombination between closely linked repeats but is necessary for DNA damage checkpoint activation which is associated with interchromosomal recombination.
A group of neurons in the medulla expressing the tachykinin precursor 1 promote rhythmic breathing, but also elicit substantial motor behaviors, suggesting a dual role for these neurons in the medulla.
Mukulika Ray, Ashley Mae Conard ... Erica Larschan
Combining computational and experimental approaches reveals that the loss of a maternal transcription factor influences sex-biased differential splicing in the early zygotic transcriptome at genes that are critical for normal developmental processes.
