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In a prospective, population-based cohort, high polygenic risk and infection with Fusobacterium nucleatum have a small, yet independent impact on coronary heart disease risk.

Mnemonic mechanisms of differentiation and integration within the medial temporal lobe occur concurrently during the learning of local and global environmental knowledge.

During perceptual decision making, maximizing total reward in the long term requires trading reward in the short term for a faster improvement in perceptual representations.

Mobility across ecological contexts and continents is more important to describe the worldwide spread of bacterial resistance to aminoglycosides (a family of antibiotics), than the consumption of aminoglycosides itself.

The odor-elicited responses of olfactory receptor neurons consist of a discrete set of four spike pattern motifs, each with distinct adaptation properties, together amplifying distinctions between similar and temporally complex chemical inputs such as odor plumes.

A theory is presented that explains why some ion channels tend to open in response to membrane stretching, which posits that channel closing is disfavored by the morphological energetics of the lipid bilayer, and increasingly so under lateral tension.

An essential role for ACAT in conferring 25HC-mediated protection against bacterial and viral infection has been uncovered.

Combined patch-clamp fluorometry with ANAP, a fluorescent non-canonical amino acid, uncovers transitions in the activation pathway of human H_V1 that are modulated by voltage and the pH gradient.

The development of an integrative computational-experimental approach for identifying small molecules that can disrupt RNA:protein interactions in vitro and in cells led to the identification of several inhibitors of YBX1 in the micromolar range, including a previously approved drug.

The transcriptional network for the GAL regulon induction in the pathogenic fungus Candida albicans represents an important advance in the evolution of the regulatory circuits, and would make a nice addition to the textbook version of eukaryotic gene regulation.