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    1. Neuroscience

    Multiple event segmentation mechanisms in the human brain

    Tan T Nguyen, Joset A Etzel ... Jeffrey M Zacks
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Representation of male features in the female mouse accessory olfactory bulb, and their stability during the estrus cycle

    Oksana Cohen, Yoram Ben-Shaul
    Electrophysiological recordings in female mice show that response profiles of accessory olfactory bulb neurons remain stable during the course of the estrus cycle.
    1. Neuroscience

    Nonlinear feedback modulation contributes to the optimization of flexible decision-making

    Xuanyu Wu, Yang Zhou
    Precise feedback connections in posterior parietal cortex enable iterative computation between decision processes, optimizing flexible decision-making reliability.
    1. Physics of Living Systems

    Design principles of transcription factors with intrinsically disordered regions

    Wencheng Ji, Ori Hachmo ... Ariel Amir
    Intrinsically disordered regions in transcription factors enhance both target binding probability and search efficiency.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Telomeres control human telomerase (TERT) expression through non-telomeric TRF2

    Antara Sengupta, Soujanya Vinayagamurthy ... Shantanu Chowdhury
    Telomere length controls hTERT expression by modulating TRF2 distribution and PRC2-mediated repression, highlighting a self-regulatory mechanism in cancer.
    1. Neuroscience

    Sparse innervation and local heterogeneity in the vibrissal corticostriatal projection

    Kenza Amroune, Lorenzo Fontolan ... Ingrid Bureau
    Functional connectivity mapping reveals sparse, specific, and largely complementary cortical innervation of individual striatal medium spiny neurons within overlapping and loosely topographical projections from the barrel cortex.
    1. Neuroscience

    Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing

    Jiho Park, Grayson O Sipe ... Mriganka Sur
    Astrocytic GABA transporter 3 is essential for preserving the integrity of neuronal population dynamics in accurately encoding and representing sensory information.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Non-cognate immunity proteins provide broader defenses against interbacterial effectors in microbial communities

    Abigail Knecht, Denise Sirias ... Karine A Gibbs
    A biochemical and bioinformatics approach shows how T6SS immunity proteins bind to and neutralize a range of non-cognate effectors, which is critical for promoting bacterial fitness in mixed-strain environments.