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Page 55 of 1,873
    1. Neuroscience

    Inhibitory columnar feedback neurons are involved in motion processing in Drosophila

    Miriam Henning, Madhura D Ketkar ... Marion Silies
    Inhibitory GABAergic feedback neurons tune direction-selective motion signals in Drosophila, sharpening behavioral responses to rapidly changing visual stimuli and expanding canonical feedforward models of visual motion computation.
    1. Ecology
    2. Physics of Living Systems

    Cognitive simplicity drives collective route improvements in homing pigeons

    Shoubhik Chandan Banerjee, Fritz A Francisco, Albert B Kao
    A navigational model exploring social learning strategies differing in cognitive complexity in homing pigeons shows that simple averaging sufficiently explains collective route improvements, without requiring cumulative cultural evolution.
    1. Cancer Biology

    Molecular architecture of the tumor microenvironment caused by BRCA1 and BRCA2 somatic mutations in human lung adenocarcinoma

    Gaoming Liao, Xinbin Yang ... Gang Xu
    BRCA1/2 mutations rewire the lung adenocarcinoma microenvironment through distinct immune programs, with BRCA1-linked type I interferon signaling and CD8+ T activation contrasting BRCA2-linked MHC-II antigen presentation and CD4+ T differentiation.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    An engineered multi-step differentiation program in Escherichia coli for self-organized spatial patterning

    Emanuele Boni, Hélène Siboulet ... Yolanda Schaerli
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Cell Biology

    Syntaxin11 Deficiency Inhibits CRAC Channel Priming to Suppress Cytotoxicity and Gene Expression in T Lymphocytes

    Sritama Datta, Abhikarsh Gupta ... Monika Vig
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology

    Tatton-Brown-Rahman Syndrome-associated DNMT3A mutations de-repress cortical interneuron differentiation to disrupt neuronal network function

    Gareth Chapman, Julianna J Determan ... Kristen L Kroll
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology

    Endocardial TIE1 synergizes with TIE2 to regulate the atrial internal muscular network assembly

    Kai Ding, Beibei Xu ... Yulong He
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology

    Isolation of small extracellular vesicles from small volumes of blood plasma using size exclusion chromatography and density gradient ultracentrifugation

    Fang Kong, Megha Upadya ... Ming Dao
    The optimized protocol for isolating small extracellular vesicles from small blood volumes, confirmed by independent methods including cryo-electron microscopy, ensures superior purity and high yield for reliable biomarker detection.
    1. Developmental Biology
    2. Genetics and Genomics

    In situ mutational screening and CRISPR interference define apterous cis-regulatory inputs during compartment boundary formation

    Gustavo Aguilar, Michèle E Sickmann ... Martin Müller
    Early enhancer logic precisely aligns developmental boundaries by integrating HOX, GATA, and signaling inputs, ensuring correct tissue patterning and preventing mirror-image duplications in the developing wing.
    1. Computational and Systems Biology
    2. Developmental Biology

    A quantitative pipeline for whole-mount deep imaging and analysis of multi-layered organoids across scales

    Alice Gros, Jules Vanaret ... Sham Tlili
    The Tapenade pipeline enables single-cell, whole-mount 3D quantification in dense multilayer organoids, linking spatial gene co-expression and nuclear deformation to emerging tissue-scale organization.
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