A host beetle pheromone regulates development and behavior in the nematode Pristionchus pacificus

  1. Jessica K Cinkornpumin
  2. Dona R Wisidagama
  3. Veronika Rapoport
  4. James L Go
  5. Christoph Dieterich
  6. Xiaoyue Wang
  7. Ralf J Sommer
  8. Ray L Hong  Is a corresponding author
  1. California State University, Northridge, United States
  2. University of Utah, United States
  3. Max Planck Institute for Biology of Ageing, Germany
  4. Max-Planck Institute for Developmental Biology, Germany

Abstract

Nematodes and insects are the two most speciose animal phyla and nematode-insect associations encompass widespread biological interactions. To dissect the chemical signals and the genes mediating this association, we investigated the effect of an oriental beetle sex pheromone on the development and behavior of the nematode Pristionchus pacificus. We found that while the beetle pheromone is attractive to P. pacificus adults, the pheromone arrests embryo development, paralyzes J2 larva, and inhibits exit of dauer larvae. To uncover the mechanism that regulate insect pheromone sensitivity, a newly identified mutant, Ppa-obi-1, is used to reveal the molecular links between altered attraction toward the beetle pheromone, as well as hypersensitivity to its paralyzing effects. Ppa-obi-1 encodes lipid-binding domains and reaches its highest expression in various cell types, including the amphid neuron sheath and excretory cells. Our data suggests that the beetle host pheromone may be a species-specific volatile synomone that coevolved with necromeny.

Article and author information

Author details

  1. Jessica K Cinkornpumin

    California State University, Northridge, Northridge, United States
    Competing interests
    The authors declare that no competing interests exist.
  2. Dona R Wisidagama

    University of Utah, Salt Lake City, United States
    Competing interests
    The authors declare that no competing interests exist.
  3. Veronika Rapoport

    California State University, Northridge, Northridge, United States
    Competing interests
    The authors declare that no competing interests exist.
  4. James L Go

    California State University, Northridge, Northridge, United States
    Competing interests
    The authors declare that no competing interests exist.
  5. Christoph Dieterich

    Max Planck Institute for Biology of Ageing, Cologne, Germany
    Competing interests
    The authors declare that no competing interests exist.
  6. Xiaoyue Wang

    Max-Planck Institute for Developmental Biology, Tuebingen, Germany
    Competing interests
    The authors declare that no competing interests exist.
  7. Ralf J Sommer

    Max-Planck Institute for Developmental Biology, Tuebingen, Germany
    Competing interests
    The authors declare that no competing interests exist.
  8. Ray L Hong

    California State University, Northridge, Northridge, United States
    For correspondence
    ray.hong@csun.edu
    Competing interests
    The authors declare that no competing interests exist.

Reviewing Editor

  1. Oliver Hobert, Columbia University, United States

Version history

  1. Received: May 4, 2014
  2. Accepted: October 14, 2014
  3. Accepted Manuscript published: October 15, 2014 (version 1)
  4. Version of Record published: November 25, 2014 (version 2)

Copyright

© 2014, Cinkornpumin et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Jessica K Cinkornpumin
  2. Dona R Wisidagama
  3. Veronika Rapoport
  4. James L Go
  5. Christoph Dieterich
  6. Xiaoyue Wang
  7. Ralf J Sommer
  8. Ray L Hong
(2014)
A host beetle pheromone regulates development and behavior in the nematode Pristionchus pacificus
eLife 3:e03229.
https://doi.org/10.7554/eLife.03229

Share this article

https://doi.org/10.7554/eLife.03229

Further reading

  1. A beetle pheromone that lures nematode worms to an insect host can also stop their development or even kill them outright.

    1. Developmental Biology
    2. Neuroscience
    Kristine B Walhovd, Stine K Krogsrud ... Didac Vidal-Pineiro
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    Human fetal development has been associated with brain health at later stages. It is unknown whether growth in utero, as indexed by birth weight (BW), relates consistently to lifespan brain characteristics and changes, and to what extent these influences are of a genetic or environmental nature. Here we show remarkably stable and lifelong positive associations between BW and cortical surface area and volume across and within developmental, aging and lifespan longitudinal samples (N = 5794, 4–82 y of age, w/386 monozygotic twins, followed for up to 8.3 y w/12,088 brain MRIs). In contrast, no consistent effect of BW on brain changes was observed. Partly environmental effects were indicated by analysis of twin BW discordance. In conclusion, the influence of prenatal growth on cortical topography is stable and reliable through the lifespan. This early-life factor appears to influence the brain by association of brain reserve, rather than brain maintenance. Thus, fetal influences appear omnipresent in the spacetime of the human brain throughout the human lifespan. Optimizing fetal growth may increase brain reserve for life, also in aging.