Genetic Rearrangement: One genome’s junk is another’s garbage

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Figures

Junk DNA in Tetrahymena.

Left: Tetrahymena is a single-celled ciliate that stores its germline genome in a micronucleus and its somatic genome in a macronucleus. During reproduction, two micronuclei fuse to form a zygotic nucleus that splits to form a new germline micronucleus and a new somatic macronucleus. This means that the genetic material in the somatic macronuclei of the parents is discarded. Right: Germline DNA (purple; top) remains intact in the germline micronucleus, but is processed in the somatic macronucleus to form somatic DNA (blue; bottom). Junk DNA in the form of internally eliminated sequences (IES; green boxes) is removed and the DNA fragments at chromosome breakage sites (Cbs; red arrowhead) to form five chromosomes, which are stabilized by the addition of telomeres (purple triangles) at their ends.

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  1. Lydia J Bright
  2. Douglas L Chalker
(2016)
Genetic Rearrangement: One genome’s junk is another’s garbage
eLife 5:e23447.
https://doi.org/10.7554/eLife.23447