Nutrient uptake by roots often involves substrate-dependent regulated nutrient transporters. For robust uptake, the system requires a regulatory circuit within cells and a collective, coordinated behaviour across the tissue. A paradigm for such systems is boron uptake, known for its directional transport and homeostasis, as boron is essential for plant growth but toxic at high concentrations. In Arabidopsis thaliana Boron up- take occurs via diffusion facilitators (NIPs) and exporters (BORs), each presenting distinct polarity. Intriguingly, although boron soil concentrations are homogenous and stable, both transporters manifest strikingly swift boron-dependent regulation. Through mathematical modelling, we demonstrate that slower regulation of these transporters leads to physiologically detrimental oscillatory behaviour. Cells become periodically exposed to potentially cytotoxic boron levels, and nutrient throughput to the xylem becomes hampered. We conclude that, while maintaining homeostasis, swift transporter regulation within a polarised tissue context is critical to prevent intrinsic traffic-jam like behaviour of nutrient flow.
- Athanasius FM Marée
- Verônica A. Grieneisen
- Toru Fujiwara
- Susan Duncan
- Naoyuki Sotta
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
- Maria J Harrison, Reviewing Editor, Boyce Thompson Institute for Plant Research, United States
- Received: March 22, 2017
- Accepted: August 13, 2017
- Accepted Manuscript published: September 5, 2017 (version 1)
© 2017, Sotta et al.
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