Making memories last using the peripheral effect of direct current stimulation
Most memories that are formed are forgotten, while others are retained longer and are subject to memory stabilization. We show that non-invasive transcutaneous electrical stimulation of the greater occipital nerve (NITESGON) using direct current during learning elicited a long-term memory effect. However, it did not trigger an immediate effect on learning. A neurobiological model of long-term memory proposes a mechanism by which memories that are initially unstable can be strengthened through subsequent novel experiences. In a series of studies, we demonstrate NITESGON's capability to boost the retention of memories when applied shortly before, during or shortly after the time of learning by enhancing memory consolidation via activation and communication in and between the locus coeruleus pathway and hippocampus by plausibly modulating dopaminergic input. These findings may have a significant impact for neurocognitive disorders that inhibit memory consolidation such as Alzheimer's disease.
data is available: https://doi.org/10.5061/dryad.dbrv15f46
Data from: Making memories last using the peripheral effect of direct current stimulationDryad Digital Repository, doi:10.5061/dryad.dbrv15f46.
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Alzheimer Association (AARG-21-848486)
- Sven Vanneste
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Human subjects: All experiments were in accordance with the ethical standards of the Declaration of Helsinki (1964). Experiments 1-7 were approved by the Institutional Review Board at the University of Texas at Dallas, All participants signed a written informed consent and consent to publish was obtained.
- Lila Davachi, Columbia University, United States
- Received: November 15, 2021
- Accepted: May 18, 2023
- Accepted Manuscript published: May 19, 2023 (version 1)
© 2023, Luckey et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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