Browse our Research Articles

Page 2 of 1,495
    1. Cell Biology
    2. Computational and Systems Biology

    Lipid packing contributes to the confinement of caveolae to the plasma membrane

    Elin Larsson, Aleksei Kabedev ... Richard Lundmark
    Membrane insertion of Dyngo-4a results in a dynamin-independent inhibition of caveola dynamics, revealing that outer leaflet lipid packing in the plasma membrane contributes to the confinement of caveolae.
    1. Cell Biology
    2. Neuroscience

    Activity-dependent CO2 production in the axon triggers opening of Connexin32 in the Schwann cell paranode

    Jack Butler, Lowell Mott ... Nicholas Dale
    Gaseous CO2 acts as a neuron to glia messenger in peripheral myelin to trigger opening of Schwann Cell Cx32 hemichannels in response to axonal action potential propagation.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    A coma pattern-based autofocusing method resolves bacterial cold shock response at single-cell level

    Sihong Li, Zhixin Ma ... Shuqiang Huang
    A robust autofocusing method enables continuous single-cell imaging during rapid cooling, revealing sustained bacterial proliferation hidden by growth arrest inferred from optical-density measurements.
    1. Neuroscience

    Analysis of dendritic input currents during place field dynamics

    Bence Fogel, Balazs B Ujfalussy
    A new analysis method to measure the propagation of different membrane currents along complex dendritic trees reveals the conditions leading to burst firing in a computational model of place cells.
    1. Neuroscience

    Neural activity profiles reveal overlapping, intermingled subpopulations spanning area borders in mouse sensorimotor cortex

    Sohrab Salimian, Harrison Grier, Matthew Tyler Kaufman
    Single neurons in mouse sensorimotor cortex are organized by their activity features into distinct subpopulations with area-spanning footprints whose boundaries align closely with anatomical and somatotopic borders.
    1. Evolutionary Biology

    Brawn before bite in endemic Asian eutherian mammals after the end-Cretaceous extinction

    Z Jack Tseng, Qian Li, Suyin Ting
    Eutherian mammals living in China after the end-Cretaceous extinctions evolved larger tooth sizes first before becoming more specialized in their biting performance, mirroring a similar pattern in brain evolution.
    1. Cancer Biology

    Restraint of melanoma progression by cells in the local skin environment

    Yilun Ma, Mohita Tagore ... Richard M White
    Keratinocytes, which activate an EMT-like program in the skin, can prevent melanoma invasion, highlighting how changes in the tumor microenvironment can act as restraining forces in cancer.
    1. Evolutionary Biology

    Experimental evolution to thermal stress indicates climate resilience in a cosmopolitan arthropod

    Gaoke Lei, Huiling Zhou ... Shijun You
    Long-term thermal selection in Plutella xylostella drives coordinated genetic, epigenetic, and metabolic adaptations that enhance climate resilience, revealing mechanisms potentially shared across arthropod pests.
    1. Immunology and Inflammation

    Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation

    Christopher Zhe Wei Lee, Farah Tasnim ... Florent Ginhoux
    Co-culturing pluripotent stem cell-derived hepatocytes and macrophages establishes a physiologically relevant liver model that captures macrophage–hepatocyte interactions, significantly improves hepatocyte maturation, and enables more accurate prediction of immune-mediated drug toxicity.