Browse our Research Articles

Page 2 of 1,453
    1. Genetics and Genomics

    The RNA-binding protein HuR modulates the expression of the disease-linked CCL2 rs1024611G-rs13900T haplotype

    Feroz Akhtar, Joselin Hernandez Ruiz ... Srinivas Mummidi
    Bioinformatics, RNA-protein interactions, and HuR-based functional studies demonstrated that the rs13900T allele modulates CCL2 transcript levels, providing a functional link between the CCL2 rs1024611G-rs13900T haplotype and disease susceptibility/progression.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

    Long-Feng Lu, Can Zhang ... Shun Li
    CDK2-mediated TBK1 degradation via Dtx4 represents a previously unrecognized regulatory mechanism that modulates antiviral immunity in fish.
    1. Neuroscience

    Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals

    Calum Stewart, T Adam Liddle ... Tyler J Stevenson
    Transcriptomic and genomic mutations reveal the mechanistic basis of timing seasonal life history transitions.
    1. Microbiology and Infectious Disease

    ATP burst is the dominant driver of antibiotic lethality in Mycobacterium smegmatis

    Tejan Lodhiya, Aseem Palande ... Raju Mukherjee
    Multiomics and biochemical studies reveal that excess ATP levels, and not ROS, is the dominant driver for antibiotic cidality in Mycobacterium smegmatis.
    1. Neuroscience

    Between-species variation in neocortical sulcal anatomy of the carnivoran brain

    Magdalena Boch, Katrin Karadachka ... Rogier B Mars
    A large-scale investigation of carnivoran brain diversity, providing a unified description of folding patterns, their relationship to behaviour and ecology, and the foundation for future investigations of carnivoran neuroecology.
    1. Neuroscience

    Establishing synthetic ribbon-type active zones in a heterologous expression system

    Rohan Kapoor, Thanh Thao Do ... Tobias Moser
    Synthetic ribbon-type active zones are reconstituted in cultured cells using a minimal set of proteins that partially mimic structural and functional features of cochlear inner hair cell active zones.
    1. Neuroscience

    Brain-derived estrogens facilitate male-typical behaviors by potentiating androgen receptor signaling in medaka

    Yuji Nishiike, Shizuku Maki ... Kataaki Okubo
    Estrogens produced in the teleost brain increase neural sensitivity to testicular androgens by directly stimulating androgen receptor transcription, thereby eliciting male-typical behaviors.
    1. Neuroscience

    A geometric shape regularity effect in the human brain

    Mathias Sablé-Meyer, Lucas Benjamin ... Stanislas Dehaene
    fMRI and MEG results in adults and children show encoding of abstract geometric regularities in dorsal-parietal, temporal, and frontal regions, pointing to a system for symbolic geometric representation in humans.
    1. Cell Biology

    Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance

    Atsushi Matsumoto, Akihito Inoko ... Junichi Ikenouchi
    Lipid imbalance triggered by Snail-driven epithelial–mesenchymal transition creates a cholesterol-dependent vulnerability that can be therapeutically targeted to overcome chemoresistance in cancer.
    1. Cell Biology

    Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake

    J Ignacio Gutierrez, Claudia Edgar, Jessica K Tyler
    Live imaging analyses in budding yeast reveal that calorie restriction and overexpression of the mRNA binding protein Ssd1 both block deleterious age-dependent iron uptake as a mechanism to extend lifespan.