Age-specific templates improve the quality of functional alignment using hyperalignment algorithms, and the improvement is consistent across age groups, validation analyses, and datasets.
Patrick B Jonker, Mumina Sadullozoda ... Alexander Muir
Modeling the metabolic microenvironment of pancreatic tumors leads to the identification of polyunsaturated fatty acid metabolism as a vulnerability of pancreatic cancer.
Christopher Peterson, Joshua Miller ... Vitaly V Ganusov
Cooperation between individual virions of human cytomegalovirus at infecting cells leads to nonlinear scaling of cell infection probability with virion concentration.
Sebastián Cruz-Gonzalez, Ogechukwu Okpala ... John A Capra
DNA-methylation-based predictors of biological age often fail to generalize across human populations, limiting their utility as biomarkers of aging and disease.
Leiomodin 1 acts as a critical molecular switch during early muscle stem cell differentiation by sequestering the deacetylase SIRT1 in the cytoplasm to initiate the myogenic program.
Face-selective neural activity occurs concurrently across the human ventral occipito-temporal cortex, challenging traditional hierarchical models of visual object recognition where response latencies increase along the cortical hierarchy.
Heterogeneity in outcomes of differently located activating mutations of Notch indicates the need and potential for mutant specific targeting of Notch in cancer.
David C Gruskin, Daniel J Vieira ... Gaurav H Patel
Genetic influences on how the brain processes complex naturalistic stimuli can be traced back to inherited control over stable spatial and temporal features of brain function.
