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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation

    Bence Hajdusits et al.
    1. Cancer Biology
    2. Cell Biology

    CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions.

    Veethika Pandey et al.
    1. Microbiology and Infectious Disease

    Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma

    Elisa De Crignis et al.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Social fluidity mobilizes contagion in human and animal populations

    Ewan Colman et al.
    A new way of measuring sociality in human and animal contact networks reveals the link between social behavior, population density, and disease transmission.
    1. Neuroscience

    Sensory coding and the causal impact of mouse cortex in a visual decision

    Peter Zatka-Haas et al.
    Local sensory signals in visual and frontal cortex play a causal role in task performance, while widespread dorsal cortical signals correlating with movement reflect processes that do not.
    1. Neuroscience

    Resonating neurons stabilize heterogeneous grid-cell networks

    Divyansh Mittal, Rishikesh Narayanan
    1. Neuroscience

    Single caudate neurons encode temporally discounted value for formulating motivation for action

    Yukiko Hori et al.
    1. Neuroscience

    Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons

    Gabriel E Romero, Laurence O Trussell
    In a fast brainstem relay controlling hearing sensitivity, descending synaptic control from midbrain provides the dominant source of excitation, due to a distinct form of synaptic plasticity.
    1. Epidemiology and Global Health

    Efficacy profile of the CYD-TDV dengue vaccine revealed by Bayesian survival analysis of individual-level phase III data

    Daniel J Laydon et al.
    Bayesian survival analysis reveals comprehensive efficacy profile and mechanism of action for Sanofi-Pasteur’s CYD-TDV dengue vaccine, whereby vaccination acts as a silent, disease-free infection enhancing disease risk in seronegatives, but giving greater immunity in seropositives than two natural infections.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

    Barbara H Stokes et al.
    Plasmodium falciparum K13 mutations confer resistance to the antimalarial artemisinin in Asian and African parasites, with most gene-edited mutant K13 African parasite lines showing a fitness cost that may predict slow dissemination of artemisinin resistance in high-transmission settings.
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