Comprehensive mapping of wing sensory neurons in Drosophila reveals that some proprioceptors make direct connections onto flight steering motor neurons, enabling rapid feedback control during flight.
Roberta Carloni, Tadhg Devlin ... Robin C Allshire
Synthetic proteins designed to bind specific repetitive DNA sequences in the Trypanosoma brucei genome allow the identification of proteins enriched over different DNA elements.
Y-complex nucleoporin, Nup107, can regulate ecdysone production by affecting the transcription of Halloween genes and levels of RTK receptor, torso, for the metamorphic transition from larva to pupa.
Stress activates a locus coeruleus–spinal dorsal horn noradrenergic circuit that drives mechanical pain hypersensitivity through Hes5-positive astrocytes.
Zachary L Reitz, Bita Pourmohsenin ... Marnix H Medema
Automated detection of metallophore biosynthesis reveals that metal-chelating non-ribosomal peptides are widespread, chemically diverse, and deeply rooted in bacterial evolution.
A conserved glucagon signaling pathway links high-fat diet-induced metabolic imbalance to cardiac arrhythmia through hormone-producing cells and heart-innervating neurons that regulate rhythmicity.
Merry Faye E Graff, Emma EM Heeg ... Sarah J Childs
Loss of foxf2 in zebrafish leads to a reduced pericyte progenitor pool in embryos and progresses to severe cerebrovascular defects over the lifespan, suggesting that cerebral small vessel disease in adults has roots in development.
Concurrent decoding of acoustic detail and linguistic structure enables natural, intelligible speech synthesis from limited human cortical recordings, resolving a fundamental constraint in neural speech reconstruction.
The adjoint propagation framework enables the concurrent flow of signals and errors, providing a biologically and physically plausible learning mechanism.
