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Spatiotemporal patterns of neocortical activity around hippocampal sharp-wave ripples
J Karimi Abadchi et al.
The hippocampus and neocortex engage in waves of mutual excitation wherein a sharp wave-ripple may occur at any time before, during or after the peak of the hippocampal-neocortical activation.
as a locus affecting nicotine preference in zebrafish and human smoking behaviour
Judit García-González et al.
Zebrafish studies are able to predict loci and biological pathways affecting human behaviour, paving the way to better understanding of the biological underpinnings of psychiatric disease.
UBP12 and UBP13 negatively regulate the activity of the ubiquitin-dependent peptidases DA1, DAR1 and DAR2
Hannes Vanhaeren et al.
Genetics and Genomics
Microbiology and Infectious Disease
Global genome diversity of the
Susanne U Franssen et al.
Genomic data for the parasites that cause visceral leishmaniasis provides the first global picture of the diversity and evolution of the pathogen and the epidemiology of this fatal tropical disease.
An abundant quiescent stem cell population in
Malpighian tubules protects principal cells from kidney stones
Chenhui Wang, Allan C Spradling
renal stem cells are exceptional in abundance, require induction to produce a single cell type, principal cells, and mitigate damage during adulthood associated with external stresses.
Stem Cells and Regenerative Medicine
Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration
Konstantinos Sousounis et al.
Experimental manipulation of a core DNA damage response factor and cell-cycle checkpoint regulators reveals a key role for these processes in the progenitor cells that fuel limb regeneration.
Physics of Living Systems
Sperm chemotaxis is driven by the slope of the chemoattractant concentration field
Héctor Vicente Ramírez-Gómez et al.
The slope of the chemoattractant concentration gradient is a driving force for sperm chemotaxis, by coordinating the entrainment of information flow between sensing, signaling and motility.
Structural Biology and Molecular Biophysics
Polyunsaturated fatty acid analogues differentially affect cardiac Na
, and K
channels through unique mechanisms
Briana M Bohannon et al.
Whole brain delivery of an instability-prone
transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome
Mirko Luoni et al.
Immunology and Inflammation
Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination
Marisa Stebegg et al.
Older individuals have impaired conventional dendritic cell and T follicular helper cell formation upon vaccination, which can be rescued by treatment with a TLR7 agonist.
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