The loss of FMRP does not affect how neuronal ribosomes are stalled or where they are stalled, but reduces the number of neuronal RNA granules that contain stalled ribosomes.
Massimiliano Semeraro, Giuseppe Negro ... Davide Marenduzzo
In a polymer model of chromatin that explicitly incorporates different types of transcription factors, both specialised and mixed factories emerge naturally, with their composition governed by their size.
Although physical exercise could be a beneficial protective factor for brain health in later life, older adults tend to overestimate their actual levels of activity.
Tetrahymena germline chromosome ends contain germline-limited sequences that are removed by chromosome breakage, a critical step for programmed DNA elimination of other germline-limited sequences and successful sexual reproduction.
Extrachromosomal circular DNA has been identified as a novel component of stress granule cores, indicating its essential involvement in eukaryotic stress response pathways at the level of protein synthesis.
The cerebellum and ventral tegmental area interact during unexpected omissions of aversive outcomes in humans, supporting a role for reward-like prediction error signaling in fear extinction learning.
ACC contains specialized neurons that sustain rich action-relevant information after action execution, enabling prolonged action monitoring, and supporting complex associative linking across events.
