Browse our Research Articles

Page 2 of 1,137
    1. Genetics and Genomics

    Engineering of the endogenous HBD promoter increases HbA2

    Mandy Y Boontanrart, Elia Mächler ... Jacob E Corn
    1. Stem Cells and Regenerative Medicine

    Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle

    Nurul Jannah Mohamed Nasir, Hans Heemskerk ... Lisa Tucker-Kellogg
    Myoglobin iron contributes to the formation and poor healing of muscle pressure injuries, that is, bedsores, and iron-chelation therapy can be administered after prolonged pressure to increase survival of the damaged tissue.
    1. Developmental Biology
    2. Evolutionary Biology

    Antagonistic role of the BTB-zinc finger transcription factors Chinmo and Broad-Complex in the juvenile/pupal transition and in growth control

    Sílvia Chafino, Panagiotis Giannios ... Xavier Franch-Marro
    Stage identity and developmental progression in insects is controlled by sequential expression of temporal-specific transcription factors.
    1. Ecology
    2. Evolutionary Biology

    Tradeoffs explain scaling, sex differences, and seasonal oscillations in the remarkable weapons of snapping shrimp (Alpheus spp.)

    Jason P Dinh, SN Patek
    Observational field analyses demonstrate that within a species, variation in animal weapon size corresponds to individual differences in the costs and benefits of weaponry.
    1. Neuroscience

    Early-life experience reorganizes neuromodulatory regulation of stage-specific behavioral responses and individuality dimensions during development

    Reemy Ali Nasser, Yuval Harel, Shay Stern
    Early-life experiences and neuromodulatory mechanisms shape discontinuous behavioral plasticity across developmental stages and modify the spectrum of long-term individuality patterns within isogenic populations.
    1. Cancer Biology

    Proteomic characteristics reveal the signatures and the risks of T1 colorectal cancer metastasis to lymph nodes

    Aojia Zhuang, Aobo Zhuang ... Chen Ding
    Based on the proteomics results, T1 CRC LNM prediction models were built using machine learning, the functional differences and biomarkers between LNM-negative and LNM-positive patients were revealed.
    1. Physics of Living Systems

    Vein fate determined by flow-based but time-delayed integration of network architecture

    Sophie Marbach, Noah Ziethen ... Karen Alim
    Relative hydraulic resistance, shear rate, and pressure in a vascular network integrate the network's architecture via fluid flow, and determine vein dynamics, with a time delay, in the prototypical organism Physarum polycephalum.
    1. Genetics and Genomics

    Limitations of principal components in quantitative genetic association models for human studies

    Yiqi Yao, Alejandro Ochoa
    It is always better to use mixed effects models over principal components association regression for genetic association studies of continuous traits, since the former models family structure and close relatives are always found in real human studies.