Browse our Research Articles

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    1. Neuroscience

    Modulating task-outcome value to mitigate real-world procrastination via noninvasive brain stimulation

    Zhiyi Chen, Zhilin Ren ... Tingyong Feng
    The perceived value of task outcomes, rather than task aversiveness, predicts reduced everyday procrastination following transcranial direct current stimulation, and offers a potential target for behavioral intervention.
    1. Biochemistry and Chemical Biology

    The chromokinesin Kid (KIF22) forms a homodimer, moves processively along microtubules, and transports double-stranded DNA

    Shinsuke Niwa, Natsuki Furusaki ... Kyoko Chiba
    Kid is reclassified as a processive chromokinesin that directly couples double-stranded DNA to microtubule-based transport.
    1. Neuroscience

    Larger language models better align with neural representations of natural language

    Zhuoqiao Hong, Haocheng Wang ... Ariel Y Goldstein
    Embeddings from larger language models and relatively earlier layers better predict neural activity during natural language.
    1. Computational and Systems Biology

    Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription, and splicing from single-cell RNA sequencing data with TSvelo

    Jiachen Li, Zhe Wang ... Ye Yuan
    TSvelo provides a comprehensive RNA velocity mathematics framework that can model the cascade of gene regulation, transcription, and splicing.
    1. Cell Biology
    2. Physics of Living Systems

    Sarcomere dynamic instability and stochastic heterogeneity drive robust cardiomyocyte contraction

    Daniel Haertter, Lara Hauke ... Christoph F Schmidt
    A non-monotonic force–velocity relationship in cardiac sarcomeres causes dynamic instability, leading to stochastic heterogeneity in contracting cardiomyocytes, which can have a protective function.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Acyl carrier protein is essential for apicoplast biogenesis in malaria parasites independent of fatty acid synthesis

    Sage WR Geher, Seyi Falekun ... Paul A Sigala
    Malaria parasites have evolved a noncanonical function for the apicoplast acyl carrier protein in stabilizing pyruvate kinase II, a metabolic hub essential for isoprenoid synthesis and parasite survival.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    +Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability

    Darren Wethington, Saeed Ahmad ... Jayajit Das
    Stochastic fluctuations play an important role in the MCMV-induced NK cell clonal expansion that ultimately gives rise to memory NK cells.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci

    Michele Marconcini, Steeve Cruchet ... Richard Benton
    Selection of animal populations and of cultured cells provides complementary datasets to identify candidate genes involved in conferring resistance to a natural insecticide.
    1. Cancer Biology

    Nerve injury-induced protein 2 preserves lysosomal membrane integrity to suppress ferroptosis

    Jin Zhang, Miranda Bustamante ... Xinbin Chen
    Revealing a role for NINJ2 in maintaining lysosomal homeostasis and preventing ferroptosis, laying the foundation for the development of cancer therapeutics targeting NINJ2.