In mammalian neocortex, opposing Krüppel-like factor (KLF) transcription factors first activate and then repress a genetic program related to axon outgrowth, potentially contributing to loss of cortical axon outgrowth in the adult.
Syntaxin11 directly controls a novel step in the activation of calcium channels, which helps activate genes and kill infected cells by a process distinct from moving cargo inside cells.
The activity of Dcp-1, one of Drosophila executioner caspases, is selectively regulated by the autophagy–Bruce axis, which enables distinct non–lethal functions for promoting tissue growth independent of cell death.
Adhithi R Raghavan, Kieron May ... Andreas Hochwagen
Meiotic axis protein deposition and double-strand break formation near yeast chromosome ends are regulated by multiple distinct layers of regulation, including the chromatin modifiers Sir2/3 and Dot1.
Specialized anterior intestinal cells in Caenorhabditis elegans act as sentinels, regulating pathogen responses and linking food availability to gut peptide secretion through pyruvate metabolism.
Carrying 'teaching' signals and modulating movement, two highly conserved functions of the dopaminergic system across all animals, are brought about by the same individual dopaminergic neurons in an insect larva.
Perceptual metamers reveal that the visual system averages luminance over a spatial extent four times smaller than spectral energy, but such estimates depend critically on experimental design choices.
Chloé I Charendoff, Félix V Louchez ... Agathe Subtil
The metabolic pressure exerted by a pathogen with an intracellular lifestyle drives epigenetic modifications, which modulate the transcriptional response of the host to infection.
Robert Naudascher, Stefano Brizzolara ... Roman Stocker
Juvenile brown trout rapidly respond to fine-scale temperature disturbances, demonstrating behavioral mechanisms that support resilience to sudden thermal disruptions in freshwater ecosystems.
