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    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Therapeutic downregulation of neuronal PAS domain 2 (Npas2) promotes surgical skin wound healing

    Yoichiro Shibuya et al.
    A small molecule compound Dwn1, identified through high-throughput screening using Npas2 as the molecular target, enhances wound healing in a murine incisional wound model.
    1. Epidemiology and Global Health
    2. Medicine

    Development, validation, and application of a machine learning model to estimate salt consumption in 54 countries

    Wilmer Cristobal Guzman-Vilca et al.
    A machine learning model could accurately estimate daily salt consumption in the general population and can be applied to countries lacking urine sample to compute the mean salt consumption at the population level.
    1. Cell Biology
    2. Plant Biology

    Regulation of immune receptor kinase plasma membrane nanoscale organization by a plant peptide hormone and its receptors

    Julien Gronnier et al.
    The perception of endogenous RALF signaling peptides modulates the plasma membrane nanoscale organization of receptor kinases to regulate plant immune signaling.
    1. Genetics and Genomics
    2. Plant Biology

    The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation

    Laura Arribas-Hernández et al.
    The Arabidopsis N6-methyladenosine (m6A) binding proteins ECT2 and ECT3 act redundantly in the cytoplasm to regulate m6A-containing mRNAs whose abundances are reduced in ect2/ect3/ect4 knockout plants although the locations of their polyadenylation sites remain unaffected, contrary to currently held beliefs.
    1. Genetics and Genomics
    2. Plant Biology

    Principles of mRNA targeting via the Arabidopsis m6A-binding protein ECT2

    Laura Arribas-Hernández et al.
    The Arabidopsis N6-methyladenosine (m6A)-binding protein ECT2 binds to m6A in the canonical RR[m6A]CH motif, not a plant-specific motif as previously thought, and its intrinsically disordered region contributes to mRNA binding via contacts with U-rich motifs.
    1. Microbiology and Infectious Disease

    A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli

    Anamaria Babosan et al.
    A mechanism whereby aminoglycosides-mediated SOS induction in Escherichia coli also promote high-level fluoroquinolone resistance.
    1. Neuroscience

    Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila

    Emil Kind et al.
    The fly connectome reveals dedicated cell types for processing specific kinds of visual information such as color or skylight polarization.
    1. Microbiology and Infectious Disease

    Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection

    Nicholas Rinkenberger et al.
    Overexpression of interferon-stimulated genes revealed a role for RARRES3 in restricting growth of Toxoplasma gondii by inducing early egress from human cells.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Diverse mating phenotypes impact the spread of wtf meiotic drivers in Schizosaccharomyces pombe

    José Fabricio López Hernández et al.
    Mating phenotypes are diverse in Schizosaccharomyces pombe and the natural variation can impact the spread of wtf meiotic drivers.
    1. Neuroscience

    BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk

    Qing-Tao Meng et al.
    B-type natriuretic peptide (BNP) modulates itch via BNP-NPRC pathway by enhancing NMB-NMBR signaling, which is independently of gastrin-releasing peptide (GRP)-GRPR signaling in the spinal cord.
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