Corey T Callaghan, Diana E Bowler ... Thomas Merckx
Across the tree of life, urban communities are consistently characterized by many urban-avoiding species and few urban exploiters, revealing a general pattern in biodiversity responses to urbanization.
Bordetella pertussis hijacks the host innate immune protein PGLYRP1 via tracheal cytotoxin to suppress inflammation and evade killing, revealing a novel immune evasion strategy.
Vasileios Ioakeimidis, Marco Palombo ... Claudia Metzler-Baddeley
Novel SANDI diffusion modelling reveals Huntington’s disease-related striatal abnormalities in proxy soma measures, explaining atrophy and motor impairment, and supporting SANDI indices as in vivo biomarkers of human neurodegenerative processes.
Stefan Zdraljevic, Laura Walter-McNeill ... Leonid Kruglyak
A maternal toxin-antidote element has degenerated into an antidote-only remnant in some Caenorhabditis elegans isolates, while in others, the toxin may instead be silenced by small RNAs.
The pathogenicity of MECP2 C-terminal deletions is determined by translational reading frame, enabling prediction of clinical outcome and a shared therapeutic genome editing strategy.
Carolyne Jie Huang, Samuel Pawel ... Rachel Heyard
A simulation study shows that metrics suggested to assess replication studies are useful in the translation context, but researchers need to clarify their translation goals a priori.
Separate prefrontal output channels preferentially track anxiety, exploration, and social preference, revealing how emotional context is organized into adaptive behavior.
