Browse our Research Articles

Page 2 of 1,466
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology

    Alan Monziani, Juan Pablo Unfried ... Igor Ulitsky
    EPB41L4A-AS1, a highly expressed snoRNA host long noncoding RNA, has multiple functions, positive regulation in cis of the EPB41L4A gene and a trans-acting role in supporting proper nucleolar biology.
    1. Neuroscience

    Movie reconstruction from mouse visual cortex activity

    Joel Bauer, Troy W Margrie, Claudia Clopath
    Naturalistic movie reconstruction from mouse visual cortex activity achieves high spatial and temporal fidelity.
    1. Neuroscience

    Peripheral anatomy and central connectivity of proprioceptive sensory neurons in the Drosophila wing

    Ellen Lesser, Anthony J Moussa, John C Tuthill
    Comprehensive mapping of wing sensory neurons in Drosophila reveals that some proprioceptors make direct connections onto flight steering motor neurons, enabling rapid feedback control during flight.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Automated genome mining predicts structural diversity and taxonomic distribution of peptide metallophores across bacteria

    Zachary L Reitz, Bita Pourmohsenin ... Marnix H Medema
    Automated detection of metallophore biosynthesis reveals that metal-chelating non-ribosomal peptides are widespread, chemically diverse, and deeply rooted in bacterial evolution.
    1. Neuroscience

    Descending locus coeruleus noradrenergic signaling to spinal astrocyte subset is required for stress-induced mechanical pain hypersensitivity

    Riku Kawanabe-Kobayashi, Sawako Uchiyama ... Makoto Tsuda
    Stress activates a locus coeruleus–spinal dorsal horn noradrenergic circuit that drives mechanical pain hypersensitivity through Hes5-positive astrocytes.
    1. Cell Biology

    Cardiac neurons expressing a glucagon-like receptor mediate cardiac arrhythmia induced by high-fat diet in Drosophila

    Yunpo Zhao, Jianli Duan ... Zhe Han
    A conserved glucagon signaling pathway links high-fat diet-induced metabolic imbalance to cardiac arrhythmia through hormone-producing cells and heart-innervating neurons that regulate rhythmicity.
    1. Developmental Biology

    Progressive mural cell deficiencies across the lifespan in a foxf2 model of cerebral small vessel disease

    Merry Faye E Graff, Emma EM Heeg ... Sarah J Childs
    Loss of foxf2 in zebrafish leads to a reduced pericyte progenitor pool in embryos and progresses to severe cerebrovascular defects over the lifespan, suggesting that cerebral small vessel disease in adults has roots in development.
    1. Neuroscience

    High-fidelity neural speech reconstruction through an efficient acoustic-linguistic dual-pathway framework

    Jiawei Li, Chunxu Guo ... Yuanning Li
    Concurrent decoding of acoustic detail and linguistic structure enables natural, intelligible speech synthesis from limited human cortical recordings, resolving a fundamental constraint in neural speech reconstruction.
    1. Biochemistry and Chemical Biology

    Concatenated modular BK channel constructs reveal divergent stoichiometry in gating control by LRRC26 (γ1), pore, and selectivity filter

    Guanxing Chen, Qin Li ... Jiusheng Yan
    Regulatory stoichiometry in large-conductance potassium (BK) channels diverges by mechanism, separating single-subunit activation, graded pore contributions, and collective selectivity-filter control.
    1. Neuroscience

    Adjoint propagation of error signal through modular recurrent neural networks for biologically plausible learning

    Zhuo Liu, Hao Shu ... Tao Chen
    The adjoint propagation framework enables the concurrent flow of signals and errors, providing a biologically and physically plausible learning mechanism.