Drosophila female germline tumors mutant for bam or bgcn mimic the stem cell niche to inhibit the differentiation of neighboring wild-type germline stem cells.
Neural reward signals following effort are amplified for self-benefiting outcomes but attenuated for other-benefiting outcomes, contingent upon reward magnitude and individual effort sensitivity.
Elena Badillo Goicoechea, Phillip F Agres ... Joel L Voss
Meta-analysis indicates that network-targeted non-invasive brain stimulation consistently enhances memory function supported by the hippocampal network, thus providing robust evidence that specific memory abilities rely on specific modifiable brain networks.
A newly developed chemo-immunological strategy enabled detection of acetoacetate-mediated lysine acetoacetylation, identified the associated regulatory enzymes, and revealed its distinct biological functions and physiological significance.
The Drosophila ryanodine receptor plays a conserved role in setting functional and structural muscle properties, regulates embryonic muscle development and could be used to assess the impact of human RYR1 mutations.
A Gata3 enhancer-embedded long non-coding RNA, Dreg1, was identified as being specifically required for optimal group 2 innate lymphoid cell development.
Mofida Abdelmageed, Premkumar Palanisamy ... Anirban Paul
Progressive DNA polymerase kappa relocalization in aging neurons associates with increased DNA damage and identifies a novel cell type- and activity-dependent role in neuronal genome maintenance.
Marco Nigro, Lucas Silva Tortorelli ... Hongdian Yang
Inhibiting locus coeruleus input to the medial prefrontal cortex in mice impaired task performance, affected the tuning of single cortical neurons and disrupted population dynamics and encoding capacity during attentional switching.
A biologically plausible reinforcement learning model that integrates associative memory and hippocampal remapping explains context-dependent flexible behavior, neural dynamics, and psychosis-related symptoms.
