Browse our Research Articles

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    1. Structural Biology and Molecular Biophysics

    Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division

    Jianwei Li, Yutong He ... Min Luo
    Structural and biochemical analyses reveal how E. coli FtsEX accommodates EnvC asymmetry to regulate amidase activation during bacterial cell division.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Out-of-balance growth enables cost-free synthesis of the flagellum and other proteins in a single bacterium

    Mayra Patricia Garcia Alcala, Josiah C Kratz, Philippe Cluzel
    Surprisingly, monitoring single bacteria expressing constitutive or flagellar genes reveals faster growth, a benefit driven by inherited, cost-free growth factors, whereas bulk measurements show an expected net fitness cost.
    1. Neuroscience

    Loose coupling between Ca2+ channels and release sensors as a synaptic correlate of higher-order brain function

    Grit Bornschein, Max Schwarze ... Hartmut Schmidt
    Identical pyramidal neuron synapses use distinct presynaptic calcium influx-transmitter release coupling architectures in prefrontal and primary somatosensory cortices, shaping synaptic properties to support area-specific cortical functions.
    1. Ecology
    2. Genetics and Genomics

    Plasticity associated with adoption of social roles in clown anemonefish

    Lili F Vizer, Douglas Alvarado ... Pete Buston
    During the establishment of size-based dominance hierarchies in clown anemonefish, an individual's social context shapes its growth trajectory through coordinated changes in feeding behavior, aggressive behaviors, and gene expression.
    1. Ecology
    2. Microbiology and Infectious Disease

    Tracking West Nile virus dynamics using viral loads from trapped mosquitoes

    Punya Alahakoon, Ian Marchinton ... James A Hay
    Mosquito-pool Ct values reflect biologically meaningful variation in viral load, while integrating viral kinetics improves prevalence estimates and helps distinguish potentially infectious from non-infectious mosquitoes.
    1. Developmental Biology
    2. Neuroscience

    foxQ2 marks fast-acting interneurons including dopaminergic neurons of mushroom bodies and central complex in the beetle Tribolium castaneum

    Ying Pang, Bastian Klußmann-Fricke ... Gregor Bucher
    In insects, foxQ2 is part of the genetic code that specifies neurons contributing to the higher-order brain centers, including dopaminergic and other fast-acting neurons.
    1. Developmental Biology

    Light-entrained chromatin priming poises rapid metamorphosis in a marine sponge

    Huifang Yuan, Oceane Blard ... Sandie M Degnan
    Planetary and habitat-specific environmental cues combine to induce rapid and extensive changes in chromatin state and gene expression necessary for larval settlement and metamorphosis in the marine sponge Amphimedon queenslandica.
    1. Cell Biology

    A GCN1-independent activator of the kinase GCN2

    JiaYi Zhu, Giulia Emanuelli ... Stefan J Marciniak
    GCN2 can be pharmacologically activated independently of GCN1, revealing flexibility in the mechanisms governing kinase activation.
    1. Developmental Biology
    2. Genetics and Genomics

    Integration of ATAC- and RNA-sequencing identifies chromatin and transcriptomic signatures in classical and non-classical zebrafish osteoblasts and indicates mechanisms of entpd5a regulation

    Kleio Petratou, Martin Stehling ... Stefan Schulte-Merker
    Computational analyses of large datasets and molecular dissection reveal the promoter organisation of the osteoblast marker entpd5a and suggest novel regulators of osteogenesis.
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    1. Ecology
    2. Plant Biology

    Genetic canalization of nutrient resorption in the widespread grass Phragmites australis under salt stress

    Lele Liu, Wenyi Sheng ... Weihua Guo
    Salinity does not alter nutrient resorption efficiency, which is instead shaped by phylogeographic history and latitude.