Browse our Research Articles

Novel SANDI diffusion modelling reveals Huntington’s disease-related striatal abnormalities in proxy soma measures, explaining atrophy and motor impairment, and supporting SANDI indices as in vivo biomarkers of human neurodegenerative processes.

A maternal toxin-antidote element has degenerated into an antidote-only remnant in some Caenorhabditis elegans isolates, while in others, the toxin may instead be silenced by small RNAs.

The pathogenicity of MECP2 C-terminal deletions is determined by translational reading frame, enabling prediction of clinical outcome and a shared therapeutic genome editing strategy.

A simulation study shows that metrics suggested to assess replication studies are useful in the translation context, but researchers need to clarify their translation goals a priori.

Adolescent suicidality is linked to riskier choices through stronger attraction to high-reward gambles and blunted mood responses to safe rewards.

Separate prefrontal output channels preferentially track anxiety, exploration, and social preference, revealing how emotional context is organized into adaptive behavior.

LRRK2 couples brain-derived neurotrophic factor (BDNF) signaling to synaptic actin remodeling, defining a novel mechanism of LRRK2 synaptic function and highlighting early, targetable pathways in Parkinson’s disease.

The genomic response of endothelial cells to hypoxia via MOA-seq transcription factor occupancy profiling identified known and novel HIF1A-associated and independent cis-regulatory elements, which defined ten distinct hypoxic kinetic clusters.