Browse our Research Articles

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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    From multiplicity of infection to force of infection in sparsely sampled high-transmission Plasmodium falciparum populations

    Qi Zhan, Kathryn E Tiedje ... Mercedes Pascual
    Queuing theory links multiplicity of infection (MOI) to force of infection (FOI), enabling the estimation of transmission intensity for falciparum malaria (and other infectious diseases) from sparsely sampled surveys.
    1. Ecology

    Dopamine and its receptor DcDop2 are involved in the coevolution between ‘Candidatus Liberibacter asiaticus’ and Diaphorina citri

    Xiaoge Nian, Jiayun Li ... Songdou Zhang
    CLas hijacks the DA/DcDop2-miR-31a-AKH-JH signaling cascade to improve D. citri lipid metabolism and fecundity, while simultaneously promoting its replication.
    1. Neuroscience

    Paraventricular thalamus hyperactivity mediates stress-induced sensitization of unlearned fear but not stress-enhanced fear learning (SEFL)

    Kenji J Nishimura, Denisse Paredes ... Michael R Drew
    Chemogenetic and in vivo recording approaches reveal how persistent hyperactivity in the posterior paraventricular thalamus promotes sensitization of fear responses to unlearned threats after stress exposure.
    1. Neuroscience

    Neural signatures of model-based and model-free reinforcement learning across prefrontal cortex and striatum

    Bruno Miranda, James L Butler ... Steven W Kennerley
    Single-neuron recordings reveal that anterior cingulate cortex and caudate nucleus encode the interaction between rewards, state transitions, and choices that underlies flexible, goal-directed decision-making.
    1. Biochemistry and Chemical Biology

    Exploration of precision coregulator TR-FRET identifies diverse signatures for LXR ligands relevant to discovery of nonlipogenic ABCA1 inducers

    Megan S Laham, Martha S Ackerman-Berrier ... Gregory RJ Thatcher
    Coregulator TR-FRET profiling reveals ligand-specific LXR signaling signatures that can guide the therapeutic design of ABCA1-inducing LXR agonists with attenuated risk of hepatic lipogenesis.
    1. Neuroscience

    Esr1-dependent signaling and transcriptional maturation in the medial preoptic area of the hypothalamus shape the development of mating behavior during adolescence

    Koichi Hashikawa, Yoshiko Hashikawa ... Garret D Stuber
    Esr1 directs adolescent transcriptional maturation of medial preoptic GABAergic neurons, enabling the normal development of mating behavior in male and female mice.
    1. Neuroscience

    Multi-timescale neural adaptation underlying long-term musculoskeletal reorganization

    Roland Philipp, Yuki Hara ... Kazuhiko Seki
    Long-term motor recovery after musculoskeletal alteration relies on gradually developing novel compensatory movements to overcome the rigid, maladaptive timing of stable muscle synergies.
    1. Neuroscience

    Tunable Bessel beam two-photon fluorescence microscopy for high-speed volumetric imaging of brain dynamics

    Mengyang Jacky Li, Jinghui Wang ... Tian-Ming Fu
    Tunable Bessel beam two-photon fluorescence microscopy enables high-speed volumetric intravital imaging of subcellular dynamics within living mouse brains with fully tunable spatial resolution and volume coverage, allowing flexible sampling and measurements of vascular, neuronal, and immune dynamics.
    1. Biochemistry and Chemical Biology

    Single-step in vitro reconstitution of the Escherichia coli ribosome mediated by two GTPase factors, EngA and ObgE

    Aya Sato, Weng Yu Lai ... Yoshihiro Shimizu
    A multi-step ribosome assembly method involving changes in ion concentration and temperature can now be carried out in a single step using the two GTPase factors, EngA and ObgE.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Constraints on the G1/S transition pathway may favor selection of multicellularity as a passenger phenotype

    Tom Louis Ducrocq, Damien Laporte, Bertrand Daignan-Fornier
    A genetic analysis in yeast establishes that multicellularity can arise as a side-effect (passenger phenotype) of a completely independent fitness advantage unrelated to the benefits of group formation itself.