Browse our Research Articles

Page 2 of 1,464
    1. Neuroscience

    The influence of sample size and covariate distributions on neuroanatomical normative modeling

    Camille Elleaume, Bruno Hebling Vieira ... Nicolas Langer
    Systematic analyses show that normative model performance strongly depends on sample size and covariate distributions, larger samples yield more stable fits, while misaligned covariates introduce systematic distortions in predictions.
    1. Neuroscience

    Dynamics of mesoscale brain network during visual discrimination learning revealed by chronic, large-scale single-unit recording

    Tian-Yi Wang, Chengcong Feng ... Zhengtuo Zhao
    During the acquisition of correct rejection response, rankings of functional connection separated for cortical and subcortical regions, which is predictive of the peak timing of visual information encoding across the network.
    1. Structural Biology and Molecular Biophysics

    Structure of the human CTF18−RFC clamp loader bound to PCNA

    Giuseppina R Briola, Mohammad Tehseen ... Alfredo De Biasio
    Human CTF18–RFC employs a unique structural stabilization mechanism to optimize PCNA loading and stimulate DNA synthesis by the leading-strand polymerase.
    1. Neuroscience

    Inverted encoding of neural responses to audiovisual stimuli reveals super-additive multisensory enhancement

    Zak Buhmann, Amanda K Robinson ... Reuben Rideaux
    A multivariate analysis of electroencephalography activity reveals super-additive enhancements to the neural encoding of audiovisual stimuli, providing new insights into how the brain integrates multisensory information to optimise spatial localisation.
    1. Structural Biology and Molecular Biophysics

    Protein-induced membrane strain drives supercomplex formation

    Maximilian C Pöverlein, Alexander Jussupow ... Ville RI Kaila
    Respiratory supercomplex formation relieves molecular strain of mitochondrial membranes and reshapes global protein motions, linking membrane reorganization to respiratory function.
    1. Medicine

    Gender differences in submission behavior exacerbate publication disparities in elite journals

    Chaoqun Ni, Isabel Basson ... Vincent Larivière
    Gender differences in submission behavior, driven by self-perceptions of novelty and peer discouragement, limit women’s representation in high-impact journals and, in turn, their scientific visibility and career advancement.
    1. Computational and Systems Biology
    2. Neuroscience

    Motor biases reflect a misalignment between visual and proprioceptive reference frames

    Tianhe Wang, J Ryan Morehead ... Jonathan S Tsay
    The pattern of reaching biases is stable across contexts and can be attributed to a misalignment between eye-centric and body-centric representations of position.
    1. Neuroscience

    Unravelling the neurocognitive mechanisms underlying counterconditioning in humans

    Lisa Wirz, Maxime C Houtekamer ... Erno Hermans
    Counterconditioning improved safety memory retrieval over regular extinction, showing a shift away from vmPFC towards nucleus accumbens, and may thereby be a promising new treatment option.
    1. Developmental Biology
    2. Neuroscience

    Cell cycle-dependent cues regulate temporal patterning of the Drosophila central brain neural stem cells

    Gonzalo N Morales Chaya, Mubarak Hussain Syed
    Intrinsic cell cycle progression governs developmental time in neural stem cells by regulating temporal gene transitions that generate neural diversity.
    1. Genetics and Genomics
    2. Neuroscience

    Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy

    Eric R Wengert, Sophie R Liebergall ... Ethan M Goldberg
    Brain slice electrophysiology, immunohistochemistry, and in vivo two-photon calcium imaging identify circuit dysfunction and epilepsy mechanism in a Kcnc1-A421V/+ mouse model of developmental and epileptic encephalopathy.