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Pigmentation that confers protective function of RPE is not underlaid by a specific gene expression profile, reviled by microscopic imaging together with single-cell RNA sequencing.

Mirlet7 functions as a molecular brake of CD8⁺IL17a⁺ T cells (Tc17) inflammation and chronic obstructive pulmonary disease via direct regulation RAR-related orphan receptor gamma t (RORγt).

A foundation for analyzing epigenetic changes within the context of regulatory architectures that enable heredity.

Clonotypic tracing of SARS-CoV-2–responsive T cells reveals vaccination-induced dominant Tfh clonotypes, not pre-existing T cells, associated with sustained humoral response, and can serve as an index of antigen-specific antibody longevity.

Revealing YBR238C's involvement in the TORC1–mitochondria feedback loop deepens our understanding of aging biology, emphasizing the TOMITO concept as a crucial mechanism in cellular aging regulation.

Empirical experiments and computational modeling reveal a stochastic world model on gravity for stability inference that represents gravity’s vertical direction as a Gaussian distribution.

Single molecule reconstitution of PI3Kβ synergistic activation reveals mechanism for rapid PI(3,4,5)P₃ production during immune cell signaling.

Insights from integrating evolutionary predictions and protein dynamics unveil how specific mutations in the SARS-CoV-2 spike protein epistatically interact in order to influence spike protein interaction with human cells, potentially altering the virus's infectivity and immune evasion capabilities.