Browse our Research Articles

Page 2 of 1,399
    1. Cell Biology

    Forward genetics in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency

    Delaney Kaper, Uroš Radović ... Marc Pilon
    Polyunsaturated fatty acids are not genetically replaceable in the nematode C. elegans and only mutations that help free ferrous ions can boost the activity of a poorly functioning desaturase enzyme.
    1. Microbiology and Infectious Disease

    Unraveling CRP/cAMP-mediated metabolic regulation in Escherichia coli persister cells

    Han G Ngo, Sayed Golam Mohiuddin ... Mehmet Orman
    CRP/cAMP plays a crucial role in the metabolic shift of Escherichia coli persisters from an anabolic state to oxidative phosphorylation, which is essential for their survival during antibiotic treatment.
    1. Evolutionary Biology

    Diverse prey capture strategies in teleost larvae

    Duncan S Mearns, Sydney A Hunt ... Herwig Baier
    The evolution of hunting behavior in fish larvae has arrived at different, species-specific solutions, recombining a shared repertoire of locomotor and eye movement motifs.
    1. Microbiology and Infectious Disease

    Heat stress induces phage tolerance in Enterobacteriaceae

    Fan Zhang, Hao-Ze Chen ... Jia-Feng Liu
    Bacterial persistence against phages enables survival under infection, and heat treatment enhances this tolerance, facilitating resistance evolution and influencing the effectiveness of phage therapy.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma

    M Reza Bahranifard, Jessica Chan ... C Ross Ethier
    Magnetically steered mesenchymal stem cells significantly lowered intraocular pressure for 9 months in mice, motivating the translation of this technology for the treatment of glaucoma.
    1. Structural Biology and Molecular Biophysics

    The C-terminus of the multi-drug efflux pump EmrE prevents proton leak by gating transport

    Merissa Brousseau, Da Teng ... Katherine A Henzler-Wildman
    The C-terminal tail acts as a secondary gate to regulate substrate access into the primary binding site for transport across the membrane.
    1. Cell Biology
    2. Medicine

    The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

    Fan Zhang, Yuan Wang ... Xianpeng Ge
    CHMP5 is crucial in preventing skeletal progenitor cell senescence and abnormal bone formation, and senolytic drugs represent potential therapeutic medicine for musculoskeletal abnormalities associated with a dysfunctional endolysosomal pathway.
    1. Cell Biology

    The molecular logic of Gtr1/2- and Pib2-dependent TORC1 regulation in budding yeast

    Jacob H Cecil, Cristina M Padilla ... Andrew P Capaldi
    Dual regulation of TORC1 by Gtr1/2 and Pib2 drives cells into three distinct signaling states, establishing a new paradigm for graded TORC1 signaling.
    1. Neuroscience

    Multifaceted role of galanin in brain excitability

    Nicolas N Rieser, Milena Ronchetti ... Stephan CF Neuhauss
    The neuropeptide galanin modulates whole-brain activity and stress responses in zebrafish, revealing a complex, receptor-dependent role in seizure regulation with implications for epilepsy, and related neurological disorders.
    1. Neuroscience

    Cestode larvae excite host neuronal circuits via glutamatergic signalling

    Anja de Lange, Hayley Tomes ... Joseph V Raimondo
    Parasitic tapeworm larvae release glutamate and other excitatory molecules that can directly excite brain neurons.