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    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

    Bishnu P Paudel et al.
    Human telomerase unfolds and extends parallel G-quadruplexes using a unique mechanism involving its RNA template.
    1. Computational and Systems Biology
    2. Neuroscience

    A unified computational model for cortical post-synaptic plasticity

    Tuomo Mäki-Marttunen et al.
    Biochemically detailed modelling of pathways leading to post-synaptic plasticity reveals the dependence of neocortical LTP/LTD on the availability of different proteins and stimulation patterns.
    1. Evolutionary Biology

    Plasticity and evolutionary convergence in the locomotor skeleton of Greater Antillean Anolis lizards

    Nathalie Feiner et al.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers

    María Angélica Bravo Núñez et al.
    The wtf meiotic drivers change the fitness landscape of meiosis in outcrossed Schizosaccharomyces pombe demonstrating that genetic parasites can favor the evolution of variants that disrupt meiotic fidelity.
    1. Computational and Systems Biology
    2. Developmental Biology

    A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation

    Bjoern Gaertner et al.
    Ribosome profiling and loss-of-function during human ESC pancreatic differentiation reveal abundant lncRNA translation and an essential role for translated LINC00261 in beta cell differentiation, likely through a trans-regulatory, microprotein-independent mechanism.
    1. Neuroscience

    Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior

    Kazuki Shiotani et al.
    Individual neurons of ventral tenia tecta which is a part of olfactory cortex tune to specific time windows in the behavioral context during odor-guided goal-directed behaviors.
    1. Developmental Biology
    2. Medicine

    RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1

    Md Rakibul Hasan et al.
    RAB23 regulates calvarial bone and suture development both independently through, and by cross-talk between, Hedgehog and fibroblast growth factor signaling.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An analog to digital converter controls bistable transfer competence development of a widespread bacterial integrative and conjugative element

    Nicolas Carraro et al.
    A new multistep hierarchical cascade controls activation of an integrative and conjugative element in a small subpopulation of cells in its bacterial host, yielding proficient DNA transferring cells.
    1. Neuroscience

    Male-predominant galanin mediates androgen-dependent aggressive chases in medaka

    Junpei Yamashita et al.
    In medaka fish, galanin-expressing neurons in the medial preoptic area occur nearly exclusively in males and mediate androgen-dependent male–male aggressive chases.
    1. Neuroscience

    Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of Down syndrome

    Javier Zorrilla de San Martin et al.
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