Browse our Research Articles

Page 2 of 1,419
    1. Neuroscience

    Policy shaping based on the learned preferences of others accounts for risky decision-making under social observation

    HeeYoung Seon, Dongil Chung
    Simulating others' preferences underlies riskier choices when being observed, driven by beliefs about observers' risk attitudes and supported by TPJ–dmPFC connectivity.
    1. Cell Biology

    Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells

    Scott D Zawieja, Grace A Pea ... Michael J Davis
    Lymphatic muscle cells, but not CD34+ adventitial cells, exhibited pacemaker behaviors including pressure-dependent depolarization, pressure-dependent calcium mobilization during diastole, and propagated contraction waves induced by focal, optogenetic depolarization via channel rhodopsin2.
    1. Cancer Biology
    2. Developmental Biology

    Dissecting infant leukemia developmental origins with a hemogenic gastruloid model

    Denise Ragusa, Chun Wai Suen ... Cristina Pina
    The hemogenic gastruloid model of embryonic blood development captures multi-wave haematopoiesis and enables interrogation of infant leukaemia cell-of-origin.
    1. Neuroscience

    Dynamic estimation of the attentional field from visual cortical activity

    Ilona M Bloem, Leah Bakst ... Sam Ling
    Visuocortical activity in humans reveals that the spatial focus of covert attention flexibly shifts and expands in accordance with task demands.
    1. Immunology and Inflammation

    Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

    Tianhan Li, Liaoxun Lu ... Lichen Zhang
    Using Xcr1Cre-Gfp Rosa26LSL-DTA Apoe–/– model and Xcl1–/– Apoe–/– mouse model reveal an essential non-redundant role for the XCL1-XCR1 axis in cDC1-mediated atherogenesis.
    1. Structural Biology and Molecular Biophysics

    p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners

    Anamari Brdar, Christian Osterburg ... Volker Dötsch
    p53 isoforms induce cellular stress based on their only partially folded states.
    1. Neuroscience

    Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of fragile X syndrome

    Huei-Bin Wang, Natalie E Smale ... Christopher S Colwell
    These findings provide convincing evidence of the beneficial effects that restored biological rhythms may have on disease pathophysiology and symptoms.
    1. Microbiology and Infectious Disease

    The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis

    Junghoon Lee, Scot P Ouellette
    For the first time, a function for the second messenger molecule, cyclic di-AMP, in Chlamydia has been described, revealing its role in regulating chlamydial developmental cycle progression.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Regulatory networks of KRAB zinc finger genes and transposable elements changed during human brain evolution and disease

    Yao-Chung Chen, Arnaud Maupas, Katja Nowick
    Primate cross-species analysis of interactions between transposable elements and KRAB-ZNF genes with the new TEKRABber tool highlights human-specific interactions with potential relevance to Alzheimer’s disease.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Inhibition of the UFD-1-NPL-4 complex triggers an aberrant immune response in Caenorhabditis elegans

    Rajneesh Rao, Alejandro Aballay, Jogender Singh
    Inhibition of the UFD-1-NPL-4 complex activates immune responses in Caenorhabditis elegans that reduce gut pathogen load but simultaneously compromise host survival.