Browse our Research Articles

Page 2 of 1,497
    1. Neuroscience

    How attention simplifies mental representations for planning

    Jason da Silva Castanheira, Christina Chang He ... Stephen M Fleming
    Spatial attention controls the information people become aware of and, in turn, incorporate into simplified perceptual representations for use in multi-step planning.
    1. Developmental Biology
    2. Neuroscience

    The microtubule-binding protein EML3 is required for mammalian embryonic growth and cerebral cortical development, and Eml3 null mice are a model of cobblestone brain malformation

    Isabelle Carrier, Eduardo Diez ... Roderick McInnes
    Absence of EML3 in mice leads to delayed embryonic development, small size, perinatal lethality, and the over-migration of neuroblasts due to a defective pial basement membrane.
    1. Neuroscience

    Theta beta ratio in attention deficit hyperactivity disorder using a multiverse analysis

    Dawid Strzelczyk, Andrea Vetsch, Nicolas Langer
    Individual alpha peak frequency and aperiodic neural activity shape theta-beta ratio estimates, limiting their value as an ADHD biomarker.
    1. Computational and Systems Biology
    2. Neuroscience

    Comparing the outputs of intramural and extramural grants funded by National Institutes of Health

    Xiang Zheng, Qiyao Yang ... B Ian Hutchins
    Funding mechanisms impact the cost effectiveness of the science conducted, as extramural NIH grants to universities excel at producing papers and citations, while intramural NIH hiring more effectively translates to clinical impact.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Inferring variant-specific effective reproduction numbers from combined case and sequencing data

    Marlin D Figgins, Trevor Bedford
    Integrating case counts with genomic sequences quantifies real-time transmission advantages of viral variants.
    1. Immunology and Inflammation

    Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

    Peter Georgiev, Sheila Johnson ... Arlene H Sharpe
    A comprehensive investigation of extracellular asparagine utilization highlights its role as a critical regulator of murine CD4+ T cell activation, differentiation, and function.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Canonical and phosphoribosyl ubiquitination coordinate to stabilize a proteinaceous structure surrounding the Legionella-containing vacuole

    Adriana Steinbach, Chetan Mokkapati ... Shaeri Mukherjee
    Two families of ubiquitin ligases secreted by the intracellular pathogen Legionella pneumophila utilize distinct chemistries to form a stable, ubiquitin-rich structure around the vacuole, which is subsequently disassembled as infection progresses.
    1. Immunology and Inflammation

    TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy

    Josselyn D Barahona, Liping Yang ... Wayne M Yokoyama
    Uterine natural killer (NK) cells require TGF-β to be derived from conventional NK cells and contribute to successful pregnancy.
    1. Immunology and Inflammation
    2. Neuroscience

    Cribriform plate microenvironment assembles a suppressive myeloid network during EAE-induced neuroinflammation

    Collin Laaker, Martin Hsu ... Zsuzsanna Fabry
    Regulatory immune cells accumulate at the nose-to-brain interface during neuroinflammation, potentially dampening damaging immune responses.
    1. Cell Biology

    Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia

    Qian Lyu, Qingchao Li ... Huijie Zhao
    Deficiency in any of the interdependent C2a proteins (CCDC108, MYCBPAP, and CFAP70) collapses this central pair microtubule-associated projection, disrupting vertebrate ciliary movement, and causing primary ciliary dyskinesia phenotypes in mice.