Browse our Research Articles

CHD4 directly limits transcription factor binding to chromatin, which prevents activation of silent or cryptic enhancers but facilitates activity of active enhancers.

Inhibiting PRMT1 and PRMT5 renders HR-proficient ovarian and breast cancers highly vulnerable to PARP inhibition by suppressing BRCAness and amplifying DNA-damage-driven innate immune signaling.

The acquisition and expression of Pavlovian conditioned responding are shown to be lawfully related to objectively specifiable temporal properties of the events the animal is learning about.

HLA-DRA intronic haplotype associates with opposite effects on type 1 diabetes and celiac disease, refining genetic risk prediction and implicating complement genes C4A and C4B in divergent autoimmune pathways.

Single-cell profiling reveals CD55+CD248+ tendon stem/progenitor cells.

Cautious action timing under threat depends on glutamatergic signaling from the subthalamic nucleus to the midbrain, revealing a circuit mechanism for adaptive goal-directed behavior.

Disrupting left superior frontal sulcus selectively impaired perceptual but not value-based decisions, revealing segregated prefrontal circuits for integrating sensory evidence versus subjective preferences in human choice behaviour.

Facial emotion representations expand from sensory cortex to prefrontal regions across development, suggesting that the prefrontal cortex matures with development to enable a full understanding of facial emotion.

Centralized migration accelerates adaptation and drives parallel evolution, emphasizing the key influence of spatial organization on evolutionary dynamics across systems from pathogen transmission to species range shifts.

Profiling cell-specific immune responses reveals altered neutrophil function and enhanced T-cell mediated cell death following acute in vivo exposure to tobacco-flavored e-cigarette aerosol using single-cell technology.