Browse our Research Articles

Page 2 of 1,493
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Correlates of protection against African swine fever virus identified by a systems immunology approach

    Kirill Lotonin, Francisco Brito ... Artur Summerfield
    Dissecting protective versus detrimental immune responses uncovers biomarkers and mechanisms that can inform the rational design and evaluation of live attenuated vaccines against African swine fever virus.
    1. Medicine

    Differential regulation of hepatic macrophage fate by Chi3l1 in metabolic dysfunction-associated steatotic liver disease

    Jia He, Bo Chen ... Zhao Shan
    Chi3l1 binding to glucose protects Kupffer cells and limits MASLD progression.
    1. Structural Biology and Molecular Biophysics

    Conformational variability of HIV-1 Env trimer and viral vulnerability

    Yiwei Cao, Wonpil Im
    Large-scale all-atom simulations of a full-length, glycosylated HIV-1 Env trimer in an asymmetric membrane reveal a rigid ectodomain and highly diverse conformational landscapes in the membrane-proximal region and transmembrane domain.
    1. Neuroscience

    Disinformation elicits learning biases

    Juan Vidal-Perez, Raymond J Dolan, Rani Moran
    Learning from potential disinformation introduces specific cognitive biases, causing individuals to systematically deviate from an idealized Bayesian updating strategy.
    1. Immunology and Inflammation

    Deciphering interferon functions in avian influenza using receptor knockout models in the natural host

    Mohanned Naif Alhussien, Hanna Kaisa Vikkula ... Benjamin Schusser
    Interferon receptor knockout chickens uncover how type I and III interferons differentially shape avian antiviral immunity and influenza disease outcomes.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Estimating probabilities of malaria importation in southern Mozambique through modelling P. falciparum genomics and mobility patterns

    Arnau Pujol, Arlindo Chidimatembue ... Alfredo Mayor
    Malaria importation in Matutuine district from southern Mozambique is strongly contributing to sustaining transmission, with Inhambane province being the main source of importation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Systematic characterisation of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry

    Hao Jiang, Jimena Druker ... Angus I Lamond
    A robust workflow for the identification of proline hydroxylation sites in proteins was established, using hydrophilic interaction chromatography enrichment and LC-MS/MS together with refining and filtering parameters during data analysis.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into the recruitment of viral type 2 IRES to ribosomal preinitiation complex for protein synthesis

    Deepakash Das, Tanweer Hussain
    The viral type 2 internal ribosome entry site uses a unique mechanism to hijack the host ribosomal machinery by interacting with initiator tRNA and 40S head.
    1. Neuroscience

    Intrinsic properties link a network model to zebra finch song

    Nelson D Medina, Dan Margoliash
    Whole-cell recordings paired with a network model show that post-inhibitory rebound excitation in premotor neurons couples intrinsic excitability to the temporal structure of learned birdsong.
    1. Microbiology and Infectious Disease

    Mycobacterium tuberculosis partitions the Krebs cycle under iron starvation

    Agnese Serafini, Acely Garza-Garcia ... Riccardo Manganelli
    Mycobacterium tuberculosis rewires central carbon metabolism to circumvent iron-dependent metabolic routes during iron starvation.