Funding mechanisms impact the cost effectiveness of the science conducted, as extramural NIH grants to universities excel at producing papers and citations, while intramural NIH hiring more effectively translates to clinical impact.
Jason da Silva Castanheira, Christina Chang He ... Stephen M Fleming
Spatial attention controls the information people become aware of and, in turn, incorporate into simplified perceptual representations for use in multi-step planning.
Absence of EML3 in mice leads to delayed embryonic development, small size, perinatal lethality, and the over-migration of neuroblasts due to a defective pial basement membrane.
Alphaherpesviruses hijack host epigenetic regulation by promoting HDAC1/2 nuclear export and degradation to activate the DNA damage response, revealing new antiviral therapeutic targets.
Michael B Heskett, Athanasios E Vouzas ... Mathew J Thayer
Stable allele-specific epigenetic regulation creates cellular mosaicism of numerous autosomal dosage-sensitive genes involved in human neurological and developmental disorders.
Two families of ubiquitin ligases secreted by the intracellular pathogen Legionella pneumophila utilize distinct chemistries to form a stable, ubiquitin-rich structure around the vacuole, which is subsequently disassembled as infection progresses.
Lenacapavir disrupts HIV-1 capsid elasticity, inducing mechanical rupture at the nuclear pore, highlighting that altering viral material properties can be a viable antiviral drug design strategy.
