Browse our Research Articles

Page 2 of 1,368
    1. Cancer Biology

    Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

    Weijie Wu, Miao Yu ... Hongquan Zhang
    Tumor-suppressive protein FRMD8 inhibits breast cancer progression by regulating the level of ERα and has the possibility to be a potential target for overcoming tamoxifen treatment resistance.
    1. Evolutionary Biology

    Developing a crop- wild-reservoir pathogen system to understand pathogen evolution and emergence

    Mark McMullan, Lawrence Percival-Alwyn ... Neil Hall
    Evidence for those pathogen genes selected specifically for success on crops.
    1. Neuroscience

    Dynamic gamma modulation of hippocampal place cells predominates development of theta sequences

    Ning Wang, Yimeng Wang ... Dong Ming
    A subset of hippocampal place cells, which is phase-locked to fast gamma rhythms, compressively encodes information at precessing slow gamma phases and therefore predominates to theta sequence development.
    1. Neuroscience

    Mechanisms that regulate the C1-C2B mutual inhibition control functional switch of UNC-13

    Haowen Liu, Lei Li ... Zhitao Hu
    A novel mechanistic mechanism in UNC-13/Munc13 regulates synaptic neurotransmitter release at the Caenorhabditis elegans neuromuscular junction.
    1. Cell Biology

    Myristoylated Neuronal Calcium Sensor-1 captures the preciliary vesicle at distal appendages

    Tomoharu Kanie, Roy Ng ... Peter K Jackson
    Neuronal Calcium Sensor-1 (NCS1) is a protein that captures the preciliary vesicle in the early step of the cilium formation.
    1. Cell Biology

    A hierarchical pathway for assembly of the distal appendages that organize primary cilia

    Tomoharu Kanie, Beibei Liu ... Peter K Jackson
    Comprehensive analyses of localization, hierarchy, and function of the proteins located at the distal appendages of the centriole.
    1. Medicine

    Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest

    Zhen Wang, Jie Zhu ... Xiang Zhou
    Exogenous mitochondrial transplantation improves cardiac function after cardiopulmonary resuscitation (CPR) may be related to improving mitochondrial function, reducing the oxidative stress response, and decreasing apoptosis in myocardial cells.
    1. Cancer Biology

    STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer

    Huan Fang, Huichun Liang ... Ceshi Chen
    STAMPBL1 activates the transcription of GRHL3 by interacting with FOXO1 in nucleus, thereby upregulating the HIF1α/VEGFA axis and promoting angiogenesis in TNBC tumors, independently of its DUB activity.
    1. Neuroscience

    Active vision of bees in a simple pattern discrimination task

    HaDi MaBouDi, Jasmin Richter ... Lars Chittka
    Bumblebees refine visual discrimination through selective and structured scanning, demonstrating a dynamic interplay between movement and perception in pattern recognition.
    1. Cancer Biology
    2. Physics of Living Systems

    Mechanistic insight for T-cell exclusion by cancer-associated fibroblasts in human lung cancer

    Joseph Ackermann, Chiara Bernard ... Martine D Ben Amar
    The crosstalk between cancerous lesions and the immune system in the lungs demonstrates the complex role of fibroblasts.