Cell biology and animal model analysis in mice shows that molecules involved in glycolytic metabolism could potentially serve as therapeutic targets for the treatment of neurological diseases.
Thibaut Sellinger, Frank Johannes, Aurélien Tellier
The developed statistical method paves the way for next generation demographic and selection inference by combining information from several heritable genomic and epigenomic markers.
Felix Michaud, Ruggiero Francavilla ... Lisa Topolnik
Early alterations in VIP interneuron activity may contribute to disruptions in CA1 hippocampal circuits and cognitive deficits in the 3xTg mouse model of Alzheimer's disease.
The cannabinoids cannabidiol, cannabidivarin, and the newly identified 331-18A demonstrate antitumoral effects in Notch1-mutated leukemia, underscoring the potential and complexity of Cannabis as a novel treatment for cancer.
Inhibiting the RiBi pathway impedes both EMT and MET processes, enhancing chemotherapy efficacy and presenting a novel avenue to tackle advanced breast cancer treatment resistance.
The phenotype of mutant potassium channels described here allows the mechanistic dissection of the complex process of potassium channel gating in the pathology-relevant KCNH family.
Harlan P Stevens, Carly V Winegar ... Stephen R Piccolo
Approximately 13% of figures in biology-related research articles are difficult for people with red/green colorblindness to decipher, but machine-learning models can help to identify these.
