Browse our Research Articles

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    1. Developmental Biology

    MATR3 is essential for oocyte growth and maturation quality through a dual molecular mechanism

    Yibing Bao, Zhenzi Zuo ... Chao Wang
    MATR3 coordinates oocyte transcription and follicular paracrine signaling to maintain normal oocyte growth and female fertility.
    1. Neuroscience

    Infants at high and low likelihood for autism show different EEG developmental trajectories in speech tracking and statistical learning

    Michel Godel, Ana Fló ... Marie Schaer
    In an auditory statistical learning experiment, infants at high likelihood for autism showed reduced neural entrainment to syllables, atypical developmental trajectories for word segmentation, and diminished novelty orientation to words.
    1. Neuroscience

    Enhanced tactile coding in rat neocortex under darkness

    Kotaro Yamashiro, Shiyori Tanaka ... Yuji Ikegaya
    Temporary darkness enhances the neural separability of tactile textures in the rat somatosensory cortex, revealing how sensory coding rapidly adapts to the absence of vision.
    1. Ecology
    2. Microbiology and Infectious Disease

    Environmental temperature is a strong driver of subspecies competition in the Drosophila microbiome

    Juan Bosco Gracia Alvira, Stefanie Migotti ... Christian Schlötterer
    Changes in abiotic factors, such as temperature, can affect the host fitness indirectly by modulating subspecies dynamics of key taxa, which are usually overlooked in microbiome research.
    1. Immunology and Inflammation

    DGKα and ζ deficiency causes regulatory T-cell dysregulation, destabilization, and conversion to pathogenic T-follicular helper cells to trigger IgG1-predominant autoimmunity

    Lei Li, Hongxiang Huang ... Xiao-Ping Zhong
    Diacylglycerol kinases (DGKs) α and ζ secure Treg stability, enforce CD28-dependence, and block conversion to pathogenic Tfh cells, safeguarding against autoimmune disease.
    1. Cell Biology

    Defective neuronal differentiation in Lowe syndrome is associated with mitochondrial dysfunction and impaired cilia-related Sonic Hedgehog signaling

    Grzegorz Walkiewicz, Siyu Chen ... Yang Sun
    OCRL deficiency is associated with mitochondrial dysfunction, altered ciliary signaling, and disrupted neural cell-state regulation across multiple experimental models of Lowe syndrome.
    1. Stem Cells and Regenerative Medicine

    Synergistic inhibition of Notch signaling and forced cell cycle re-entry drive Müller glia reprogramming in uninjured mouse retina

    Baoshan Liao, Chengshang Lyu ... Wenjun Xiong
    Stimulating cell cycle entry and suppressing Notch signaling drive mammalian Müller glia to proliferate and generate diverse, long-surviving neuron-like cells, offering insights into overcoming retinal regeneration barriers.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites

    Deborah Maus, Elyzana Putrianti ... Martin Blume
    Inhibiting the mitochondrial bc1-complex disrupts energy production in mature Toxoplasma gondii bradyzoites, suggesting a metabolic vulnerability in the parasite's chronic, drug-resistant stage.
    1. Genetics and Genomics

    A systematic interactome of Saccharomyces cerevisiae SET1C expands its functional landscape and identifies candidate regulatory connections

    Pierre Luciano, Kihyun Park ... Vincent Geli
    A comprehensive two-hybrid map of the Set1C interactome broadens understanding of Set1C subunit functions and identifies a novel link between Set1C and arginine methylation.
    1. Neuroscience

    Modulating task-outcome value to mitigate real-world procrastination via noninvasive brain stimulation

    Zhiyi Chen, Zhilin Ren ... Tingyong Feng
    The perceived value of task outcomes, rather than task aversiveness, predicts reduced everyday procrastination following transcranial direct current stimulation, and offers a potential target for behavioral intervention.