Browse our Research Articles

A comprehensive investigation of extracellular asparagine utilization highlights its role as a critical regulator of murine CD4+ T cell activation, differentiation, and function.

Stable allele-specific epigenetic regulation creates cellular mosaicism of numerous autosomal dosage-sensitive genes involved in human neurological and developmental disorders.

Uterine natural killer (NK) cells require TGF-β to be derived from conventional NK cells and contribute to successful pregnancy.

Regulatory immune cells accumulate at the nose-to-brain interface during neuroinflammation, potentially dampening damaging immune responses.

Deficiency in any of the interdependent C2a proteins (CCDC108, MYCBPAP, and CFAP70) collapses this central pair microtubule-associated projection, disrupting vertebrate ciliary movement, and causing primary ciliary dyskinesia phenotypes in mice.

Medial prefrontal cortex activity is not required for learning or execution of adaptive avoidance behavior, despite encoding select task features.

Lenacapavir disrupts HIV-1 capsid elasticity, inducing mechanical rupture at the nuclear pore, highlighting that altering viral material properties can be a viable antiviral drug design strategy.

A method for arrayed CRISPRi screening in organoids enables the investigation of morphogenesis in human stem cell-derived tissues, revealing the roles of ZIC2, SOX11, and ZNF521 in neural tube closure.

DNA methylation suppresses H2A.Z deposition by inhibiting recruitment of the chaperone SRCAP, while the structural study suggests that methylated DNA can make the H2A.Z nucleosome slightly more accessible.

The brain uses separate prediction error and prediction uncertainty signals to trigger event boundaries.