Browse our Research Articles

Page 2 of 1,483
    1. Cancer Biology
    2. Developmental Biology

    Tumors mimic the niche to inhibit neighboring stem cell differentiation

    Yang Zhang, Yuejia Wang ... Shaowei Zhao
    Drosophila female germline tumors mutant for bam or bgcn mimic the stem cell niche to inhibit the differentiation of neighboring wild-type germline stem cells.
    1. Neuroscience

    Effort produces after-effects costly for others but valued for self

    Ya Zheng, Rumeng Tang
    Neural reward signals following effort are amplified for self-benefiting outcomes but attenuated for other-benefiting outcomes, contingent upon reward magnitude and individual effort sensitivity.
    1. Neuroscience

    Subregional activity in the dentate gyrus is amplified during elevated cognitive demands

    Charlotte Castillon, Shintaro Otsuka ... Anis Contractor
    Selective engagement of suprapyramidal dentate gyrus neurons during a high-demand pattern separation task reveals blade-specific circuit engagement for enhancing mnemonic discrimination.
    1. Neuroscience

    A meta-analysis suggests that TMS targeting the hippocampal network selectively improves episodic memory

    Elena Badillo Goicoechea, Phillip F Agres ... Joel L Voss
    Meta-analysis indicates that network-targeted non-invasive brain stimulation consistently enhances memory function supported by the hippocampal network, thus providing robust evidence that specific memory abilities rely on specific modifiable brain networks.
    1. Chromosomes and Gene Expression

    Identification of the regulatory elements and protein substrates of lysine acetoacetylation

    Qianyun Fu, Terry Nguyen ... Y George Zheng
    A newly developed chemo-immunological strategy enabled detection of acetoacetate-mediated lysine acetoacetylation, identified the associated regulatory enzymes, and revealed its distinct biological functions and physiological significance.
    1. Developmental Biology

    Drosophila ryanodine receptor gene triggers functional and developmental muscle properties and could be used to assess the impact of human RYR1 mutations

    Monika Zmojdzian, Teresa Jagla ... Catherine Sarret
    The Drosophila ryanodine receptor plays a conserved role in setting functional and structural muscle properties, regulates embryonic muscle development and could be used to assess the impact of human RYR1 mutations.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    The long non-coding RNA Dreg1 is required for optimal ILC2 development

    Sara Quon, Adelynn Tang ... Rhys Allan
    A Gata3 enhancer-embedded long non-coding RNA, Dreg1, was identified as being specifically required for optimal group 2 innate lymphoid cell development.
    1. Neuroscience

    An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging mouse neurons

    Mofida Abdelmageed, Premkumar Palanisamy ... Anirban Paul
    Progressive DNA polymerase kappa relocalization in aging neurons associates with increased DNA damage and identifies a novel cell type- and activity-dependent role in neuronal genome maintenance.
    1. Neuroscience

    Locus coeruleus modulation of prefrontal dynamics during attentional switching in mice

    Marco Nigro, Lucas Silva Tortorelli ... Hongdian Yang
    Inhibiting locus coeruleus input to the medial prefrontal cortex in mice impaired task performance, affected the tuning of single cortical neurons and disrupted population dynamics and encoding capacity during attentional switching.
    1. Neuroscience

    Modeling flexible behavior with remapping-based hippocampal sequence learning

    Yoshiki Ito, Taro Toyoizumi
    A biologically plausible reinforcement learning model that integrates associative memory and hippocampal remapping explains context-dependent flexible behavior, neural dynamics, and psychosis-related symptoms.