Stress activates a locus coeruleus–spinal dorsal horn noradrenergic circuit that drives mechanical pain hypersensitivity through Hes5-positive astrocytes.
A conserved glucagon signaling pathway links high-fat diet-induced metabolic imbalance to cardiac arrhythmia through hormone-producing cells and heart-innervating neurons that regulate rhythmicity.
Merry Faye E Graff, Emma EM Heeg ... Sarah J Childs
Loss of foxf2 in zebrafish leads to a reduced pericyte progenitor pool in embryos and progresses to severe cerebrovascular defects over the lifespan, suggesting that cerebral small vessel disease in adults has roots in development.
Concurrent decoding of acoustic detail and linguistic structure enables natural, intelligible speech synthesis from limited human cortical recordings, resolving a fundamental constraint in neural speech reconstruction.
The adjoint propagation framework enables the concurrent flow of signals and errors, providing a biologically and physically plausible learning mechanism.
DNA damage reshapes genome-wide transcriptional bursting, with distinct burst size and frequency programs associated with differentiation, apoptosis, and survival decisions.
Yatendra Kumar, Dipta Sengupta ... Wendy A Bickmore
Acetylation of histone H3 at the nucleosome surface is associated with destabilised nucleosomes and is a useful new functional genomics mark for identifying regulatory regions of the mammalian genome.
Distal renal tubular acidosis induced by some SLC4A1 variants is characterized by cytosolic pH alkalization, reduced ATP synthesis and defective autophagy degradative flux.
Hannah H McDermott, Federico de Martino ... Ryszard Auksztulewicz
Neural responses during statistical learning reveal dissociable dynamic effects of expectation, supporting the opposing process theory within trials while demonstrating contrasting effects across trials.
