Kristopher T Jensen, Peter T Doohan ... Timothy E Behrens
Recently discovered sequence representations in prefrontal cortex can be combined with the ubiquitous principle of neural attractor dynamics to support planning in complex environments.
Violations of strong memory-based predictions trigger a cascade of changes in cognitive control, attention, and arousal, with differential impacts on the encoding of unexpected information into memory.
Jitendra Kumar, Shravan K Uppulapu ... Santosh Kumar
SUMO2ylation of redox protein p66Shc drives endothelial dysfunction by promoting oxidative stress, identifying a potential therapeutic target for cardiovascular disease.
Human forebrain organoids reveal that amyloid-driven microglia recruit killer T cells via CCL5, forming a self-amplifying neuroinflammatory loop targetable by CCR5 or CXCR3 blockade.
In mammalian neocortex, opposing Krüppel-like factor (KLF) transcription factors first activate and then repress a genetic program related to axon outgrowth, potentially contributing to loss of cortical axon outgrowth in the adult.
Syntaxin11 directly controls a novel step in the activation of calcium channels, which helps activate genes and kill infected cells by a process distinct from moving cargo inside cells.
The activity of Dcp-1, one of Drosophila executioner caspases, is selectively regulated by the autophagy–Bruce axis, which enables distinct non–lethal functions for promoting tissue growth independent of cell death.
Adhithi R Raghavan, Kieron May ... Andreas Hochwagen
Meiotic axis protein deposition and double-strand break formation near yeast chromosome ends are regulated by multiple distinct layers of regulation, including the chromatin modifiers Sir2/3 and Dot1.
Specialized anterior intestinal cells in Caenorhabditis elegans act as sentinels, regulating pathogen responses and linking food availability to gut peptide secretion through pyruvate metabolism.
Carrying 'teaching' signals and modulating movement, two highly conserved functions of the dopaminergic system across all animals, are brought about by the same individual dopaminergic neurons in an insect larva.
