An on-demand seizure model in chronically epileptic mice integrates reliability and etiological relevance, providing a mechanistically grounded, efficient platform for evaluating pharmacological interventions.
Single-cell and bulk lineage tracing reveals that adult bone marrow endothelial cells generate functional hematopoietic progenitor and mature blood cells, expanding the cell sources of postnatal hematopoiesis.
The thermosensory neuron AFD unexpectedly modulates locomotion based on tactile experience through molecular and circuit mechanisms distinct from those underlying thermosensation.
Genetic experiments combined with cellular and biochemical analyses including lipidomics performed by imaging mass spectrometry reveal that the capacity of mature B lymphocytes and germinal center B cells to synthesize some ether phospholipids is vital for normal humoral responses.
Computer simulations reveal the structural basis for a selective mechanism of ion-channel inhibition that could guide future pharmacological developments against associated human health disorders.
The kinocilium of vestibular hair cells is a unique organelle with molecular features of primary and motile cilia and may serve as an active, force-generating element within the hair bundle.
Behavioral analyses combined with genetics revealed that Caenorhabditis elegans uses an olfactory receptor-ligand module to forage for essential nutrients.
Endophilin-A3-mediated clathrin-independent endocytosis and retrograde trafficking in cancer cells regulate ICAM1 organization at the immune synapse and influence cytotoxic CD8 T cell response.
A scalable zebrafish imaging platform reveals that Foxp1 paralogues have non-redundant roles in developmental patterning of adipose morphology and adaptive remodelling capacity in response to a high-fat diet.
