Increasing CD11c+ microglial subsets in the spinal dorsal horn by intrathecal treatment of interleukin-4 alleviate pain hypersensitivity caused by nerve injury.
Fanny Eggeler, Jonathan Boulanger-Weill ... Filippo Del Bene
Genetic analyses in zebrafish reveal a new role for the Meteorin protein family in the left-right asymmetry patterning during embryonic vertebrate development.
The sense of smell is crucial for insect larvae not only to find a suitable food source but also for finding safe spaces which are free of their natural enemies.
Christopher R Lee, Gillian A Matthews ... Kay M Tye
Optogenetic manipulations and neural circuit interrogation reveal that dorsal raphe dopamine circuits can emulate different facets of a loneliness-like state, including prosociality, aversion, and vigilance.
Abundant single-stranded telomeric DNA distinguishes alternative lengthening of telomeres-positive cells and represents a potential biomarker and therapeutic vulnerability.
Elevated ubiquitin phosphorylation disrupts proteasomal function, creating a self-amplifying cycle that drives progressive protein aggregation and neuronal injury across multiple neurodegenerative conditions.
Marie-Therese Fischer, Katherine S Xue ... Lauren A O'Connell
Direct skin contact during parental care in poison frogs transmits host-adapted microbes to tadpoles, where some bacterial taxa may persist on the skin through early development.
The promotion of C1QBP accumulation by PA28γ leads to the malignant progression of tumor by affecting mitochondrial function, which could be a launch pad for therapeutic intervention of tumor development.
