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A size exclusion strategy using PEGylation of isoprenaline allowed to demonstrate that cardiac β-adrenergic receptors located in the outer surface membrane control mainly cAMP/PKA in the cytosol while those located in the T-tubule membrane control cAMP/PKA in the nucleus.

A novel form of collective mesenchymal cell migration is identified during chick gastrulation, where a dynamic 3D meshwork supported by N-cadherin-mediated adhesion coordinates movement and enhances directional migration in the unconfined space between ectoderm and endoderm.

Protein–protein interactions and localization dependencies between septin cytoskeleton and the exocyst complex using the fission yeast model system reveal one of the most conserved functions of septins in exocytosis.

A distinct subset of leaf companion cells expresses high levels of the florigen gene, and the same cells also produce other possible mobile floral regulators and small proteins.

Aging results in remodeling of the nuclear pore complex and leakage of intron-containing pre-mRNA out of the nucleus, altering gene function and mitotic stability of old cells.

Non-equilibrium thermodynamics allows signaling networks to signal downstream of certain ligands but avoid signaling from others.

Transcriptional responses to axonal damage are required for circuit repair, but these responses are restrained in injuries that leave spared axonal branches.

Preparatory attentional templates exist in two formats with distinct functional states, a default non-sensory format and a latent sensory-like format.

Routine genomic surveillance uncovered a decades-long multidrug-resistant Pseudomonas aeruginosa outbreak sustained by patient reservoirs and hospital plumbing, enabling targeted infection control measures that ultimately curtailed transmission.

Functional connectivity in rodent and human neuronal cultures is best explained by homophilic wiring rules, in which neurons preferentially form connections depending on spatial proximity and shared connectivity patterns, suggesting a unifying principle across scales.