Browse our Research Articles

Cryo-EM structures of human aquaporin AQP2 bound to the anti-trypanosomal drugs pentamidine and melarsoprol identify the molecular mechanism for drug-resistant sleeping sickness.

Synthetic ribbon-type active zones are reconstituted in cultured cells using a minimal set of proteins that partially mimic structural and functional features of cochlear inner hair cell active zones.

Estrogens produced in the teleost brain increase neural sensitivity to testicular androgens by directly stimulating androgen receptor transcription, thereby eliciting male-typical behaviors.

A large-scale investigation of carnivoran brain diversity, providing a unified description of folding patterns, their relationship to behaviour and ecology, and the foundation for future investigations of carnivoran neuroecology.

Transcriptomic and genomic mutations reveal the mechanistic basis of timing seasonal life history transitions.

Multiomics and biochemical studies reveal that excess ATP levels, and not ROS, is the dominant driver for antibiotic cidality in Mycobacterium smegmatis.

Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based epigenome editing.

Lipid imbalance triggered by Snail-driven epithelial–mesenchymal transition creates a cholesterol-dependent vulnerability that can be therapeutically targeted to overcome chemoresistance in cancer.

An alternative splicing regulator previously implicated in calcium signaling in the heart ensures cell-type-specific mRNA processing of long neuronal mRNAs in the mouse brain.

Linking biological research with disordered-systems modeling, providing new insights into gut microbiome stability, functioning, and their relationship with health.