Browse our Research Articles

Page 13 of 1,454
    1. Microbiology and Infectious Disease

    The impact of different antimicrobial exposures on the gut microbiome in the ARMORD observational study

    Leon Peto, Nicola Fawcett ... Ann Sarah Walker
    Metagenomic sequencing of stool samples from 225 hospital patients and healthy volunteers reveals the impact of different antimicrobial exposures on the gut microbiome.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Dock-and-lock binding of SxIP ligands is required for stable and selective EB1 interactions

    Teresa Almeida, Eleanor Hargreaves ... Igor Barsukov
    Structural analysis reveals a two-step EB1-SxIP binding mechanism and identifies ligand mutations that greatly enhance affinity, offering potential therapeutic avenues for targeting microtubule plus end interactions.
    1. Cell Biology

    Evidence of centromeric histone 3 chaperone involved in DNA damage repair pathway in budding yeast

    Prakhar Agarwal, Anushka Alekar ... Santanu K Ghosh
    Genetic and biochemical assays reveal the role of Scm3 in genome stability by regulating the DNA damage checkpoint pathway in budding yeast.
    1. Medicine

    Addressing cultural and knowledge barriers to enable preclinical sex inclusive research

    Brianna N Gaskill, Benjamin Phillips ... Natasha A Karp
    Targeted education corrects key misconceptions and identifies methods to influence intent to use sex-inclusive designs in in vivo studies.
    1. Stem Cells and Regenerative Medicine

    Glycogen engineering improves the starvation resistance of mesenchymal stem cells and their therapeutic efficacy in pulmonary fibrosis

    Yongyue Xu, Mamatali Rahman ... Qiong Wu
    Glycogen engineering strategies of mammalian cells were developed, which improved the survival of mesenchymal stem cells post-implantation and their therapeutic efficacy in pulmonary fibrosis model.
    1. Neuroscience

    Human neurocomputational mechanisms of guilt-driven and shame-driven altruistic behavior

    Ruida Zhu, Huanqing Wang ... Chao Liu
    Harm and responsibility differentially shape guilt and shame, which in turn drive compensatory behavior to varying extents.
    1. Physics of Living Systems

    Theory of active self-organization of dense nematic structures in the actin cytoskeleton

    Waleed Mirza, Marco De Corato ... Marino Arroyo
    Theoretical and computational modeling reveals a mechanism of active patterning of uniform isotropic actin gels into dense nematic bundles, providing a physical basis for the adaptability of the actin cytoskeleton.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A modular platform to display multiple hemagglutinin subtypes on a single immunogen

    Dana Thornlow Lamson, Faez Amokrane Nait Mohamed ... Aaron G Schmidt
    BOAS is a platform for building multivalent viral protein immunogens without a scaffold, such as a nanoparticle, to elicit broad influenza vaccine responses.
    1. Developmental Biology

    Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification

    Adiyant Lamba, Meng Zhu ... Magdalena Zernicka-Goetz
    Mouse embryo cells undergo apical-basal polarization asynchronously at the 8-cell stage, and the timing of polarization influences subsequent lineage allocation.
    1. Microbiology and Infectious Disease

    PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment

    Binayak Sarkar, Jyotsna Singh ... Rajesh S Gokhale
    In vitro, ex vivo, and in vivo studies reveal that hepatocytes are significantly infected by Mycobacterium tuberculosis which rewires the host cell metabolism to upregulate the lipid biosynthetic pathways.