Farjana Islam, Cayman Williams ... Benedict Seddon
Inhibitor of κB kinase signalling differentially controls development and survival of γδ T cell subsets through nuclear factor-κB activation and repression of receptor-interacting protein kinase 1-driven necroptosis, revealing distinct inflammatory signalling requirements from αβ T cells.
Maryam Karimian, Mark Jonathan Roberts ... Mario Senden
Principles of weakly coupled oscillators capture human figure-ground segregation and its training-induced enhancement, indicating gamma synchrony remains a plausible grouping mechanism.
The phase of cortical activity, measured in the gray matter, is organized at multiple spatial scales, with the largest scales explaining most variance in phase at a given temporal frequency.
A system to enrich yeast in metaphase of mitosis, meiosis I, or meiosis II reveals reduced spindle assembly checkpoint robustness in meiosis I and distinct kinetochore composition and phosphorylation states.
Detecting replay during longer time periods (e.g. resting state or sleep) with temporally delayed linear modeling (TDLM) requires biologically implausible event densities, and purely synthetic simulations substantially overestimate the method's sensitivity.
Elucidation of the Hox code defining forelimb positioning provides novel insights into lateral plate mesoderm patterning and the integration of vertebrate column structure and limb positioning.
Analysis of scRNA-seq data from primate embryoid bodies highlights the value of cross-species comparisons for identifying and characterizing cell types, as marker genes can evolve fast.
Direct survival benefits in larger groups rather than kin-selected indirect fitness primarily drive the evolution of division of labor in cooperatively breeding vertebrates, particularly under harsh environmental conditions.
Structural characterization of the CTLH-CRA domain-mediated pairing in the CTLH ubiquitin ligase complex enables rational engineering of interfaces with altered binding specificity.
