Alaknanda Emery, Orest W Blaschuk ... Darryl L Russell
A critical role for N-cadherin in ovarian follicular development and ovulation is demonstrated with inhibitors or knockout of N-cadherin shown to inhibit ovulation by blocking mechanotransduction of ovulatory genes.
Giorgio Nicoletti, Matteo Bruzzone ... Daniel Maria Busiello
The onset of habituation phenomena enables accurate processing of external stimuli when biological systems adapt their parameters to balance dissipation and the information between input and response.
Markus Borud Pettersen, Vemund Schøyen ... Mikkel E Lepperød
Border cells are sufficient to generate place cells and remapping during path integration in artificial neural networks, challenging the role of grid cells for spatial navigation.
Wesley H Godfrey, Judy J Lee ... Michael D Kornberg
The glycolytic enzyme phosphoglycerate mutase supports Treg function, identifying a novel therapeutic target for immune modulation and demonstrating that glycolytic regulation of T cells is more nuanced than previously appreciated.
Neoadjuvant SBRT with dalpiciclib and exemestane resulted in a 16.7% RCB 0-I rate and a 91.7% ORR, with acceptable toxicities in HR-positive, HER2-negative breast cancer patients.
There is no discernible effect of an additional year of education from a policy change on long-term structural neuroimaging measures in a large aging sample (UK Biobank).
Aurore Thomazeau, Sabine Rannio ... Per Jesper Sjöström
Neocortical timing-dependent LTD relies on non-ionotropic presynaptic NMDA receptor signaling via JNK2, challenging the textbook view that NMDA receptors are ionotropic coincidence detectors in Hebbian plasticity.
Homotypic olfactory receptor neurons in Drosophila, including CO2-sensing neurons with distinctive sheet-like dendrites, exhibit unexpected morphological diversity that may underlie functional adaptability.