Browse our Research Articles

Page 13 of 1,459
    1. Computational and Systems Biology
    2. Neuroscience

    Morphogenesis and morphometry of brain folding patterns across species

    Sifan Yin, Chunzi Liu ... L Mahadevan
    The morphogenesis of brain folding patterns across species is studied by physical gel models, simulations, and a quantitative morphometric analysis.
    1. Developmental Biology
    2. Neuroscience

    Biophysical basis for brain folding and misfolding patterns in ferrets and humans

    Gary PT Choi, Chunzi Liu ... L Mahadevan
    Physical gel models and numerical simulations have been created to study ferret brain gyrification and cortical malformations, while comparisons with human phenotypes aim to link genetics and brain morphogenesis.
    1. Immunology and Inflammation

    Class A scavenger receptor MARCO negatively regulates Ace expression and aldosterone production

    Conan JO O'Brien, Giorgio Ratti ... Ana I Domingos
    Loss of class A scavenger receptor MARCO results in elevated lung Ace expression and elevated plasma aldosterone concentrations in male mice, demonstrating an endocrine function of this immune scavenger receptor.
    1. Neuroscience

    Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex

    Louis Richevaux, Dongkyun Lim ... Desdemona Fricker
    Nonlinear dendritic integration in single presubicular neurons provides a mechanism for combining vestibular-based head-direction signals and visual landmark signals to anchor the brain’s internal compass.
    1. Structural Biology and Molecular Biophysics

    Nucleosome wrapping energy in CpG islands and the role of epigenetic base modifications

    Rasa Giniūnaitė, Rahul Sharma ... Daiva Petkevičiūtė-Gerlach
    CpG density and epigenetic modification state modulate DNA mechanics, altering its intrinsic compatibility with nucleosome formation.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection

    Alina Xiaoyu Yang, Lisa Ramos-Rodriguez ... Yang Zhou
    PLSCR1 is an IFN-λ-stimulated gene that enhances IFN-λR1 expression at both transcriptional and protein level, highlighting the potential for targeting PLSCR1 pathways in anti-influenza therapy.
    1. Microbiology and Infectious Disease

    Functional genomics reveals strain-specific genetic requirements conferring hypoxic growth in Mycobacterium intracellulare

    Yoshitaka Tateishi, Yuriko Ozeki ... Sohkichi Matsumoto
    Transposon sequencing analyses reveal that among genomically diverse clinical Mycobacterium intracellulare strains and the type strain, 131 genes were comprehensively identified as universal essential genes suggesting promising drug targets.
    1. Medicine
    2. Neuroscience

    GPR30 in spinal cholecystokinin-positive neurons modulates neuropathic pain

    Qing Chen, Hui Wu ... Xinzhong Chen
    A combination of viral strategies, electrophysiological methods, and behavioral tests reveals how GPR30 in spinal CCK+ neurons modulates neuropathic pain.
    1. Developmental Biology
    2. Genetics and Genomics

    Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically diverse Caenorhabditis nematodes

    Stephen A Banse, Christine A Sedore ... Patrick C Phillips
    Computer screening identifies that the widely prescribed vitamin A derivative all-trans retinoic acid increases both longevity and late-life health in a powerful genetic model system.
    1. Computational and Systems Biology
    2. Neuroscience

    Predictive modeling of hematoma expansion from non-contrast computed tomography in spontaneous intracerebral hemorrhage patients

    Natasha Ironside, Kareem El Naamani ... VISTA-ICH
    In spontaneous intracerebral hemorrhage patients, features of hematoma expansion can be visualized and predicted from non-contrast computed tomography using transport-based morphometry.