Browse our Research Articles

Page 13 of 1,372
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages

    Marisa S Egan, Emily A O'Rourke ... Sunny Shin
    Analysis of inflammasome responses in human macrophages reveals that inflammatory caspases and pyroptotic factors control Salmonella replication primarily within the cytosol and also within vacuoles.
    1. Developmental Biology
    2. Genetics and Genomics

    Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

    Menglei Yang, Hafiz Muhammad Jafar Hussain ... Baolu Shi
    DNAH12 is essential for sperm flagellar development and male fertility in both humans and mice by interacting with dynein proteins DNAH1 and DNALI1.
    1. Cell Biology

    CDK-mediated phosphorylation of PNKP is required for end-processing of single-strand DNA gaps on Okazaki fragments and genome stability

    Kaima Tsukada, Rikiya Imamura ... Mikio Shimada
    It was revealed that phosphorylation of the DNA repair enzyme PNKP at threonine 118 by CDK is required for DNA replication through the gap filling of Okazaki fragments.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    AI-based discovery and cryoEM structural elucidation of a KATP channel pharmacochaperone

    Assmaa Elsheikh, Camden M Driggers ... Show-Ling Shyng
    Structure-based approach identifies a KATP-binding compound that has the potential of normalizing insulin secretion in congenital hyperinsulinism by correcting defective KATP channel trafficking to the cell surface.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Microphase separation produces interfacial environment within diblock biomolecular condensates

    Andrew P Latham, Longchen Zhu ... Bin Zhang
    The microenvironment within biomolecular condensates exhibits interfacial behaviors characterized by a combination of hydrophobic and hydrophilic properties.
    1. Biochemistry and Chemical Biology

    Induction of hepatitis B core protein aggregation targeting an unconventional binding site

    Vladimir Khayenko, Cihan Makbul ... Hans Michael Maric
    Targeting two novel sites on the hepatitis B virus capsid disrupts its assembly and induces aggregation, suggesting potential for antiviral therapy development.
    1. Neuroscience

    Network segregation is associated with processing speed in the cognitively healthy oldest-ol

    Sara A Nolin, Mary E Faulkner ... Kristina Visscher
    1. Medicine

    Transparency of research practices in cardiovascular literature

    Gabriel O Heckerman, Eileen Tzng ... Adrienne Mueller
    1. Neuroscience

    Auditory cortex anatomy reflects multilingual phonological experience

    Olga Kepinska, Josue Dalboni da Rocha ... Narly Golestani
    Multilingual experience, particularly with larger phonological inventories across multilinguals’ languages, is linked to structural differences in transverse temporal gyri, highlighting experience-driven plasticity as a key factor shaping auditory cortex anatomy.