Browse our Research Articles

Page 13 of 1,418
    1. Cell Biology

    N-cadherin mechanosensing in ovarian follicles controls oocyte maturation and ovulation

    Alaknanda Emery, Orest W Blaschuk ... Darryl L Russell
    A critical role for N-cadherin in ovarian follicular development and ovulation is demonstrated with inhibitors or knockout of N-cadherin shown to inhibit ovulation by blocking mechanotransduction of ovulatory genes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Refining the resolution of the yeast genotype–phenotype map using single-cell RNA-sequencing

    Arnaud N'Guessan, Wen Yuan Tong ... Alex N Nguyen Ba
    Single-cell RNA sequencing of thousands of yeast progeny reveals how gene expression differences and heritability drive phenotypic diversity.
    1. Physics of Living Systems

    Optimal information gain at the onset of habituation to repeated stimuli

    Giorgio Nicoletti, Matteo Bruzzone ... Daniel Maria Busiello
    The onset of habituation phenomena enables accurate processing of external stimuli when biological systems adapt their parameters to balance dissipation and the information between input and response.
    1. Neuroscience

    Learning place cells and remapping by decoding the cognitive map

    Markus Borud Pettersen, Vemund Schøyen ... Mikkel E Lepperød
    Border cells are sufficient to generate place cells and remapping during path integration in artificial neural networks, challenging the role of grid cells for spatial navigation.
    1. Immunology and Inflammation

    Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

    Wesley H Godfrey, Judy J Lee ... Michael D Kornberg
    The glycolytic enzyme phosphoglycerate mutase supports Treg function, identifying a novel therapeutic target for immune modulation and demonstrating that glycolytic regulation of T cells is more nuanced than previously appreciated.
    1. Medicine

    Efficacy and safety of neoadjuvant stereotactic body radiation therapy plus dalpiciclib and exemestane for hormone receptor-positive, HER2-negative breast cancer: A prospective pilot study

    Yu Zhang, Shuo Cao ... Caigang Liu
    Neoadjuvant SBRT with dalpiciclib and exemestane resulted in a 16.7% RCB 0-I rate and a 91.7% ORR, with acceptable toxicities in HR-positive, HER2-negative breast cancer patients.
    1. Neuroscience

    Cingulate cortex shapes early postnatal development of social vocalizations

    Gurueswar Nagarajan, Denis Matrov ... Yogita Chudasama
    The normal development of social vocal behavior depends on the anterior cingulate cortex and its interaction with the vocal network during early life.
    1. Neuroscience

    No effect of additional education on long-term brain structure, a preregistered natural experiment in thousands of individuals

    Nicholas Judd, Rogier Kievit
    There is no discernible effect of an additional year of education from a policy change on long-term structural neuroimaging measures in a large aging sample (UK Biobank).
    1. Neuroscience

    Neocortical layer-5 tLTD relies on non-ionotropic presynaptic NMDA receptor signaling

    Aurore Thomazeau, Sabine Rannio ... Per Jesper Sjöström
    Neocortical timing-dependent LTD relies on non-ionotropic presynaptic NMDA receptor signaling via JNK2, challenging the textbook view that NMDA receptors are ionotropic coincidence detectors in Hebbian plasticity.
    1. Neuroscience

    Population-level morphological analysis of paired CO2- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy

    Jonathan Choy, Shadi Charara ... Chih-Ying Su
    Homotypic olfactory receptor neurons in Drosophila, including CO2-sensing neurons with distinctive sheet-like dendrites, exhibit unexpected morphological diversity that may underlie functional adaptability.