Stephania Assimopoulos, Shaun Warrington ... Stamatios N Sotiropoulos
By providing new ways to map cortico-subcortical connectivity patterns, the proposed cross-species tractography approaches directly allow novel comparative studies between the human and macaque brain and enable subsequent explorations of brain-behaviour/disease symptom associations across individuals.
Samuel Bru, Lydie Michaillat Mayer ... Andreas Mayer
In vitro reconstitution identifies how lysosome-related vacuoles coordinate the synthesis and turnover of inorganic polyphosphates to create a powerful buffer system stabilising a vital metabolic parameter, the cytosolic concentration of phosphate.
Nirujan Rameshkumar, Abhishek P Shrestha ... Thirumalini Vaithianathan
Calcium levels and structural diversity among synaptic ribbons in bipolar neurons likely enable differential encoding of visual information, revealing a potential mechanism for fine-tuning sensory signal processing.
Luz Saavedra-Sanchez, Mary S Dickinson ... Jorn Coers
The enteric bacterial Shigella secretes a virulence factor that degrades the pivotal human defense protein RNF213, thereby protecting cytosolic bacteria from interferon-driven ubiquitylation and associated innate immunity.
Restitution of RAP2A, human homolog of Drosophila asymmetric cell division regulator Rap2l, in glioblastoma neurosphere cultures targets the stemness of glioblastoma stem cells and could contribute to reduce glioblastoma expansion.
Zachary W Hoisington, Himanshu Gangal ... Dorit Ron
Novel function of Prosapip1, a scaffolding protein highly expressed in the hippocampus, in maintaining postsynaptic density integrity and plays a vital role in synaptic plasticity, learning, and memory.
Mitochondrial remodeling, ROS-dependent signaling, and diverse environmental and physiological cues underlie the initiation and persistence of locomotory activity of C. elegans in toxic H2S.
