Genetic analysis and knockout mouse model study identified calcyphosine-like (CAPSL) as a candidate disease gene in familial exudative vitreoretinopathy (FEVR), offering valuable insights into disease mechanisms.
Felix Michaud, Ruggiero Francavilla ... Lisa Topolnik
Early alterations in VIP interneuron activity may contribute to disruptions in CA1 hippocampal circuits and cognitive deficits in the 3xTg mouse model of Alzheimer's disease.
Harlan P Stevens, Carly V Winegar ... Stephen R Piccolo
Approximately 13% of figures in biology-related research articles are difficult for people with red/green colorblindness to decipher, but machine-learning models can help to identify these.
The phenotype of mutant potassium channels described here allows the mechanistic dissection of the complex process of potassium channel gating in the pathology-relevant KCNH family.
Inhibiting the RiBi pathway impedes both EMT and MET processes, enhancing chemotherapy efficacy and presenting a novel avenue to tackle advanced breast cancer treatment resistance.
The cannabinoids cannabidiol, cannabidivarin, and the newly identified 331-18A demonstrate antitumoral effects in Notch1-mutated leukemia, underscoring the potential and complexity of Cannabis as a novel treatment for cancer.
Spatial segregation is identified as the primary mechanism facilitating the coexistence of apex and mesocarnivores in the Qilian Mountain National Park, China.
A model with a mixture of three different decision strategies is developed to characterize several atypical behavioral patterns of individuals with depression and anxiety in an uncertain reward environment.
Large extracellular vesicle extrusion that eliminates neuronal protein aggregates and organelles is potentiated by uterine filling, linking reproductive status to maternal nervous system health, and demonstrating mechanobiology components in exophergenesis.
