Identification of central neural circuits and sensory pathways underlying social-sexual modulation of sperm ejection in female Drosophila unraveled cryptic mate choice, a mechanism of post-copulatory sexual selection.
Benchmark simulations show that the VEXAT muscle model is more accurate than a Hill-type muscle model at mimicking the response of biological muscle to length changes great and small.
A genome-wide screen identifies the BCAA catabolizing enzyme DBT as a master metabolic switch in the regulation of protein quality control when proteasomal activity is impaired.
During speech production, auditory regions that show speech-induced suppression are sensitive to changes in auditory feedback, suggesting that suppression may be a key mechanism underlying speech monitoring.
PINK1 deficiency in Parkinson's disease models causes toxic oxidized and iron-depleted CISD1 yet CISD1 removal benefits PINK1 mutant Drosophila indicating its potential as a therapeutic target for mitochondrial dysfunction and neurodegeneration.
Using a combination of all-atom molecular simulation and continuum membrane mechanics, M2 channels from influenza are shown to be stabilized in negative Gaussian curvature regions, such as the neck of budding viral particles, only in C2-symmetric conformations.
Genetic mouse models combined with single-cell RNA sequencing reveal the essential role of SRSF2 in directing MyoD progenitors to distinct skeletal muscle domains and controlling their differentiation through the regulation of targeted genes and alternative splicing during skeletal muscle development.
