Browse our Research Articles

Page 264 of 1,392
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate

    Minato Hirano, Gaddiel Galarza-Muñoz ... Mariano A Garcia-Blanco
    RNA processing regulates gene expression of the key transcription factor FOXP3 in T regulatory cells impacting immune tolerance and susceptibility to autoimmune disease.
    1. Cell Biology
    2. Neuroscience

    APOE expression and secretion are modulated by mitochondrial dysfunction

    Meghan E Wynne, Oluwaseun Ogunbona ... Victor Faundez
    Current models of Alzheimer's disease that put mitochondria as an endpoint of disease should be reconsidered because genetic defects affecting mitochondria by themselves can also regulate Alzheimer’s disease risk factor apolipoprotein E (APOE) expression and secretion.
    1. Neuroscience

    The nematode worm C. elegans chooses between bacterial foods as if maximizing economic utility

    Abraham Katzen, Hui-Kuan Chung ... Shawn R Lockery
    A worm with a nervous system of only 302 neurons satisfies the necessary and sufficient conditions for value-based decision making.
    1. Neuroscience

    Spatiotemporal neural dynamics of object recognition under uncertainty in humans

    Yuan-hao Wu, Ella Podvalny, Biyu J He
    Combining 7 Tesla fMRI and MEG data collected during a challenging visual recognition task revealed distinct neural representational formats in ventral visual and frontoparietal regions, and the emergence of recognition-related signals prior to category-related information.
    1. Neuroscience

    Mating activates neuroendocrine pathways signaling hunger in Drosophila females

    Meghan Laturney, Gabriella R Sterne, Kristin Scott
    Postmated increases in sucrose consumption in Drosophila melanogaster females is executed by a female specific circuit that alters neuroendocrine centers to promote hunger.
    1. Genetics and Genomics

    Sparse dimensionality reduction approaches in Mendelian randomisation with highly correlated exposures

    Vasileios Karageorgiou, Dipender Gill ... Verena Zuber
    Applied and computational results show how dimensionality reduction approaches can help in grouping correlated genetic variant-exposure associations and improve causal inference in the Mendelian randomisation framework.
    1. Neuroscience

    The normalization model predicts responses in the human visual cortex during object-based attention

    Narges Doostani, Gholam-Ali Hossein-Zadeh, Maryam Vaziri-Pashkam
    A normalization model is shown to predict responses to multiple objects across changes in the attentional state in the visual cortex, providing evidence for the role of normalization as a fundamental operation in the human brain.
    1. Neuroscience

    Task-evoked metabolic demands of the posteromedial default mode network are shaped by dorsal attention and frontoparietal control networks

    Godber M Godbersen, Sebastian Klug ... Andreas Hahn
    In the human brain, default mode network BOLD deactivations can be accompanied by both increases and decreases in glucose metabolism, depending on the respective metabolic demands of task-positive cognitive control and attention networks.
    1. Developmental Biology
    2. Neuroscience

    Local angiogenic interplay of Vegfc/d and Vegfa controls brain region-specific emergence of fenestrated capillaries

    Sweta Parab, Olivia A Card ... Ryota L Matsuoka
    Novel and common angiogenic mechanisms crucial for fenestrated brain capillary formation have been identified.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Mouse B2 SINE elements function as IFN-inducible enhancers

    Isabella Horton, Conor J Kelly ... Edward B Chuong
    An epigenomic analysis in mouse macrophages reveals that a highly abundant transposable element exhibits activity as an immune inducible regulatory element.