Browse our Research Articles

Page 4 of 1,420
    1. Neuroscience

    Dynamic estimation of the attentional field from visual cortical activity

    Ilona M Bloem, Leah Bakst ... Sam Ling
    Visuocortical activity in humans reveals that the spatial focus of covert attention flexibly shifts and expands in accordance with task demands.
    1. Microbiology and Infectious Disease

    The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis

    Junghoon Lee, Scot P Ouellette
    For the first time, a function for the second messenger molecule, cyclic di-AMP, in Chlamydia has been described, revealing its role in regulating chlamydial developmental cycle progression.
    1. Computational and Systems Biology
    2. Neuroscience

    Accept–reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

    Jessica A Haley, Tianyi Chen ... Sreekanth H Chalasani
    C. elegans foraging decisions are guided by learned environmental features, integrating recent patch quality with internal satiety to balance exploration and exploitation.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

    Khund Sayeed, Sreeja Parameswaran ... Matthew T Weirauch
    Infection of human cells by human cytomegalovirus induces massive changes to human chromatin and reduction of TEAD1 activity.
    1. Neuroscience

    Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of fragile X syndrome

    Huei-Bin Wang, Natalie E Smale ... Christopher S Colwell
    These findings provide convincing evidence of the beneficial effects that restored biological rhythms may have on disease pathophysiology and symptoms.
    1. Cancer Biology
    2. Immunology and Inflammation

    An evaluation of the tumor microenvironment through CALR, IL1R1, IFNB1, and IFNG to assess prognosis and immunotherapy response in bladder cancer patients

    Lilong Liu, Zhenghao Liu ... Zheng Liu
    A novel risk-scoring model enables personalized treatment decisions for bladder cancer patients.
    1. Structural Biology and Molecular Biophysics

    p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners

    Anamari Brdar, Christian Osterburg ... Volker Dötsch
    p53 isoforms induce cellular stress based on their only partially folded states.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Regulatory networks of KRAB zinc finger genes and transposable elements changed during human brain evolution and disease

    Yao-Chung Chen, Arnaud Maupas, Katja Nowick
    Primate cross-species analysis of interactions between transposable elements and KRAB-ZNF genes with the new TEKRABber tool highlights human-specific interactions with potential relevance to Alzheimer’s disease.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The flexible stalk domain of sTREM2 modulates its interactions with brain-based phospholipids

    David Saeb, Emma E Lietzke ... Kayla G Sprenger
    The flexible stalk region of sTREM2 binds the Ig-like domain, altering stability and ligand accessibility—a biochemically testable mechanism with broad implications for (s)TREM2 biology and rational Alzheimer's disease therapeutic design.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Inhibition of the UFD-1-NPL-4 complex triggers an aberrant immune response in Caenorhabditis elegans

    Rajneesh Rao, Alejandro Aballay, Jogender Singh
    Inhibition of the UFD-1-NPL-4 complex activates immune responses in Caenorhabditis elegans that reduce gut pathogen load but simultaneously compromise host survival.