Browse our Research Articles

Combining deep mutational scanning with CRISPR, interactome measurements, and electrophysiology reveals nuanced effects of the lectin chaperone calnexin on the pharmacological properties of 232 cystic fibrosis variants.

Shark dentition is a complex and hyper-diverse trait integrating multiple spatial levels, with mid-scale features being most crucial for functional adaptation, revealing evolutionary patterns that offer insights into distinct ecological strategies.

Structural analysis reveals a two-step EB1-SxIP binding mechanism and identifies ligand mutations that greatly enhance affinity, offering potential therapeutic avenues for targeting microtubule plus end interactions.

Genetic and biochemical assays reveal the role of Scm3 in genome stability by regulating the DNA damage checkpoint pathway in budding yeast.

Metagenomic sequencing of stool samples from 225 hospital patients and healthy volunteers reveals the impact of different antimicrobial exposures on the gut microbiome.

Targeted education corrects key misconceptions and identifies methods to influence intent to use sex-inclusive designs in in vivo studies.

Harm and responsibility differentially shape guilt and shame, which in turn drive compensatory behavior to varying extents.

Glycogen engineering strategies of mammalian cells were developed, which improved the survival of mesenchymal stem cells post-implantation and their therapeutic efficacy in pulmonary fibrosis model.

Theoretical and computational modeling reveals a mechanism of active patterning of uniform isotropic actin gels into dense nematic bundles, providing a physical basis for the adaptability of the actin cytoskeleton.