Browse our Research Articles

Page 4 of 1,370
    1. Evolutionary Biology

    Pleiotropy increases parallel selection signatures during adaptation from standing genetic variation

    Wei-Yun Lai, Sheng-Kai Hsu ... Christian Schlötterer
    Evolved gene expression changes in Drosophila simulans uncovered the interplay between parallel evolution, polymorphism, and pleiotropy and indicated that both direct and indirect effects of pleiotropy contribute to parallel evolution.
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    1. Neuroscience

    Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice

    Carlos A Sánchez-León, Guillermo Sánchez-Garrido Campos ... Javier Márquez-Ruiz
    The neuromodulatory effects of cerebellar tDCS depend on Purkinje cell somatodendritic orientation relative to the electric field, revealing a key factor for optimizing stimulation protocols and computational models.
    1. Evolutionary Biology

    Developing a crop- wild-reservoir pathogen system to understand pathogen evolution and emergence

    Mark McMullan, Lawrence Percival-Alwyn ... Neil Hall
    Evidence for those pathogen genes selected specifically for success on crops.
    1. Cancer Biology

    Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

    Weijie Wu, Miao Yu ... Hongquan Zhang
    Tumor-suppressive protein FRMD8 inhibits breast cancer progression by regulating the level of ERα and has the possibility to be a potential target for overcoming tamoxifen treatment resistance.
    1. Neuroscience

    Dynamic gamma modulation of hippocampal place cells predominates development of theta sequences

    Ning Wang, Yimeng Wang ... Dong Ming
    A subset of hippocampal place cells, which is phase-locked to fast gamma rhythms, compressively encodes information at precessing slow gamma phases and therefore predominates to theta sequence development.
    1. Neuroscience

    Diverging roles of TRPV1 and TRPM2 in warm-temperature detection

    Muad Y Abd El Hay, Gretel B Kamm ... Jan Siemens
    Different aspects of thermal stimuli, such as speed and intensity, are detected by distinct TRP channel-based mechanisms, with TRPV1 and TRPM2 playing unique roles in warmth perception and thermal decision-making.
    1. Neuroscience

    Mechanisms that regulate the C1-C2B mutual inhibition control functional switch of UNC-13

    Haowen Liu, Lei Li ... Zhitao Hu
    A novel mechanistic mechanism in UNC-13/Munc13 regulates synaptic neurotransmitter release at the Caenorhabditis elegans neuromuscular junction.
    1. Cell Biology

    Myristoylated Neuronal Calcium Sensor-1 captures the preciliary vesicle at distal appendages

    Tomoharu Kanie, Roy Ng ... Peter K Jackson
    Neuronal Calcium Sensor-1 (NCS1) is a protein that captures the preciliary vesicle in the early step of the cilium formation.
    1. Cell Biology

    A hierarchical pathway for assembly of the distal appendages that organize primary cilia

    Tomoharu Kanie, Beibei Liu ... Peter K Jackson
    Comprehensive analyses of localization, hierarchy, and function of the proteins located at the distal appendages of the centriole.
    1. Microbiology and Infectious Disease

    Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal

    Carley N Gray, Manickam Ashokkumar ... Michael Emerman
    A block to more potent and specific release of HIV from latency has been identified as a subunit of the Integrator complex, which may aid strategies for HIV cure.