Browse our Research Articles

Page 4 of 1,301
    1. Neuroscience

    Multi-level processing of emotions in life motion signals revealed through pupil responses

    Tian Yuan, Li Wang, Yi Jiang
    Intact and local emotional biological motion exerted distinct influences on pupil responses, wherein the emotional modulation observed in intact biological motion is linked to individual autistic traits.
    1. Neuroscience

    Cell class-specific long-range axonal projections of neurons in mouse whisker-related somatosensory cortices

    Yanqi Liu, Pol Bech ... Carl CH Petersen
    Whole-brain light-sheet imaging of axons segmented by trained convolutional networks reveals distinct projection patterns of genetically defined classes of neurons in primary and secondary whisker-related somatosensory cortices.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome-wide mapping of native co-localized G4s and R-loops in living cells

    Ting Liu, Xing Shen ... Zhihong Xue
    The newly developed antibody-free techniques, HepG4-seq for G-quadruplexes and HBD-seq for R-loops, robustly reveal the comprehensive maps of native G-quadruplexes and R-loops, as well as their roles in transcriptional regulation.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Systematic evaluation of multifactorial causal associations for Alzheimer’s disease and an interactive platform MRAD developed based on Mendelian randomization analysis

    Tianyu Zhao, Hui Li ... Li Chen
    A new online data analysis platform, Mendelian Randomization for Alzheimer’s Disease (MRAD), enables the identification of risk or protective factors for Alzheimer’s disease.
    1. Developmental Biology

    Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling

    Maiko Kawasaki, Katsushige Kawasaki ... Atsushi Ohazama
    Cell-cell interaction between neural crest-derived cells and mesoderm-derived cells determine cell fate of mesoderm-derived cell in tongue development through Hh signaling.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on somatostatin- and parvalbumin-expressing cortical GABAergic neurons

    Amy N Shore, Keyong Li ... Matthew C Weston
    An epilepsy-associated potassium channel variant causes neuron-type-dependent alterations in ionic currents, neuronal excitability, and network connectivity.
    1. Chromosomes and Gene Expression

    Transcriptional inhibition after irradiation occurs preferentially at highly expressed genes in a manner dependent on cell cycle progression

    Zulong Chen, Xin Wang ... Jessica K Tyler
    Genetic, cellular, and molecular analyses reveal that the reduced abundance of total nascent transcripts that occurs after irradiation is largely due to the repression of histone and rRNA encoding genes.
    1. Immunology and Inflammation

    Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor

    Chenchen Mao, Yanyu Chen ... Xiangyang Xue
    Resting natural killer cells promote the progress of colon cancer liver metastasis (CCLM), which may be exploited for novel strategies to improve therapeutic outcomes for patients with CCLM.
    1. Cancer Biology
    2. Cell Biology

    Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment

    Alexandra Urbancokova, Terezie Hornofova ... Pavla Vasicova
    Chemotherapeutics altering DNA topology evoke RNA polymerase I inhibition, rDNA damage and consequent formation of PNAs that segregate persistent rDNA lesions from the active nucleolus, with implications for rDNA maintenance and design of new cancer treatment strategies targeting rDNA repair.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Benchmarking reveals superiority of deep learning variant callers on bacterial nanopore sequence data

    Michael B Hall, Ryan R Wick ... Lachlan Coin
    Nanopore sequencing effectively resolves key challenges in bacterial small variant detection, providing a more accurate alternative to traditional sequencing methods.