A normative computational model of individual differences in mouse exploration driven by reward and threat uncertainty as well as risk sensitivity when faced with a novel object in an open field.
Ramesh Chittajallu, Anna Vlachos ... Chris J McBain
A pharmacogenetic approach provides a foundational dataset describing the influence of opioids on synaptic processing in a brain microcircuit known to be critical for driving hedonic behaviors.
Luz Saavedra-Sanchez, Mary S Dickinson ... Jorn Coers
The enteric bacterial Shigella secretes a virulence factor that degrades the pivotal human defense protein RNF213, thereby protecting cytosolic bacteria from interferon-driven ubiquitylation and associated innate immunity.
Restitution of RAP2A, human homolog of Drosophila asymmetric cell division regulator Rap2l, in glioblastoma neurosphere cultures targets the stemness of glioblastoma stem cells and could contribute to reduce glioblastoma expansion.
Zachary W Hoisington, Himanshu Gangal ... Dorit Ron
Novel function of Prosapip1, a scaffolding protein highly expressed in the hippocampus, in maintaining postsynaptic density integrity and plays a vital role in synaptic plasticity, learning, and memory.
A comparative analysis of genome-wide seasonal gene expression dynamics across four forest tree species revealed that a shared 'molecular calendar' emerges in winter, constraining gene expression evolution and potentially limiting temporal niche partitioning and species divergence in seasonal environments.
