Browse our Research Articles

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    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Neisseria gonorrhoeae LIN codes provide a robust, multi-resolution lineage nomenclature

    Anastasia Unitt, Made A Krisna ... Odile B Harrison
    LIN code offers a reliable framework for classifying gonococcal population structure, enabling straightforward exploration of isolate relationships, from broad superlineage divisions to minute single allele differences.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Hybridization breaks species barriers in long-term coevolution of a cyanobacterial population

    Gabriel Birzu, Harihara Subrahmaniam Muralidharan ... Devaki Bhaya
    Analysis of hundreds of single-cell genomes from Yellowstone National Park shows bacterial species are less cohesive than previously thought.
    1. Neuroscience

    Decision-making components and times revealed by the single-trial electroencephalogram

    Gabriel Weindel, Jelmer P Borst, Leendert van Maanen
    By modeling the single-trial electroencephalogram of participants performing perceptual decisions, and building on predictions from two century-old psychological laws, we estimate the times of information processing steps contained in decision-making.
    1. Neuroscience

    Coordinated spinal locomotor network dynamics emerge from cell-type-specific connectivity patterns

    F David Wandler, Benjamin K Lemberger ... James M Murray
    A hierarchy of models guided by experimental results from zebrafish shows that coordinated, variable-speed locomotion can emerge from network-level interactions among interneuron populations with structured spatial connectivity.
    1. Cell Biology

    JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease

    Yunpo Zhao, Jianli Duan ... Zhe Han
    A conserved signaling axis linking Drosophila adipose tissue to nephrocyte function reveals how obesity can drive kidney dysfunction and points to new opportunities for therapeutic intervention.
    1. Physics of Living Systems

    The evolution of interdisciplinarity and internationalization in scientific journals

    Huaxia Zhou, Luis A Nunes Amaral
    Analysis of ~50 million articles published in ~50 thousand journals demonstrates that journals have become more diverse in terms of both interdisciplinarity and internationalization but with some disciplinary differences.
    1. Immunology and Inflammation

    Epidermal resident memory T cell fitness requires antigen encounter in the skin

    Eric S Weiss, Toshiro Hirai ... Daniel H Kaplan
    Antigen-driven TCR signaling in the epidermis during CD8+ TRM differentiation results in a lower TGFβ requirement for persistence and increased proliferative capacity that together enhance epidermal TRM fitness.
    1. Computational and Systems Biology
    2. Neuroscience

    Morphogenesis and morphometry of brain folding patterns across species

    Sifan Yin, Chunzi Liu ... L Mahadevan
    The morphogenesis of brain folding patterns across species is studied by physical gel models, simulations, and a quantitative morphometric analysis.
    1. Cancer Biology

    Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer

    Jessica Armand, Sungsoo Kim ... Hee Won Yang
    Maintaining CDK4/6 inhibition constrains drug‑resistant breast tumors by delaying cell‑cycle entry, and adding CDK2 inhibition further deepens control to guide post‑progression therapy.
    1. Cancer Biology

    Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females

    Megan E Patton, Sherwin Kelekar ... Sayeepriyadarshini Anakk
    Transcriptomic and metabolite analysis reveal sex differences in circulation and excretion of bile acids in a mouse- model of hepatocellular carcinoma (HCC), and the identified female-specific gene profile correlates with better HCC survival.