Browse our Research Articles

Page 3 of 1,497
    1. Biochemistry and Chemical Biology

    Dynamic assembly of malate dehydrogenase–citrate synthase multienzyme complex in the mitochondria

    Joy Omini, Inga Krassovskaya ... Toshihiro Obata
    The yeast mitochondrial malate dehydrogenase–citrate synthase metabolon is a dynamic multienzyme complex that continuously assembles and disassembles in response to respiratory activity, mitochondrial matrix pH, and substrate abundances.
    1. Genetics and Genomics

    Autosomal allelic inactivation at loci with variable replication timing and dosage sensitivity

    Michael B Heskett, Athanasios E Vouzas ... Mathew J Thayer
    Stable allele-specific epigenetic regulation creates cellular mosaicism of numerous autosomal dosage-sensitive genes involved in human neurological and developmental disorders.
    1. Immunology and Inflammation

    TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy

    Josselyn D Barahona, Liping Yang ... Wayne M Yokoyama
    Uterine natural killer (NK) cells require TGF-β to be derived from conventional NK cells and contribute to successful pregnancy.
    1. Neuroscience

    Visual working memory guides attention rhythmically in humans

    Jiachen Lu, Yaochun Cai, Xilin Zhang
    Working memory alternates between remembered items in a rhythmic theta cycle.
    1. Immunology and Inflammation

    Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

    Peter Georgiev, Sheila Johnson ... Arlene H Sharpe
    A comprehensive investigation of extracellular asparagine utilization highlights its role as a critical regulator of murine CD4+ T cell activation, differentiation, and function.
    1. Chromosomes and Gene Expression

    Impacts of DNA methylation on H2A.Z deposition and nucleosome stability

    Rochelle M Shih, Yasuhiro Arimura ... Hironori Funabiki
    DNA methylation suppresses H2A.Z deposition by inhibiting recruitment of the chaperone SRCAP, while the structural study suggests that methylated DNA can make the H2A.Z nucleosome slightly more accessible.
    1. Chromosomes and Gene Expression

    Ligand-dependent enhancer activation indirectly modulates non-target promoters in a chromatin domain

    Darshika Bohra, Zubairul Islam ... Dimple Notani
    Ligand-driven enhancer activation selectively boosts target gene expression while indirectly repressing neighboring non-target genes, revealing dynamic and competitive regulation during early transcriptional responses.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Pervasive relaxed selection on spermatogenesis genes coincident with the evolution of polygyny in gorillas

    Jacob D Bowman, Neide Silva ... Vincent J Lynch
    Genes associated with male reproductive biology appear to be under relaxed selective constraint in a primate species with low sperm competition.
    1. Neuroscience

    Multiple event segmentation mechanisms in the human brain

    Tan T Nguyen, Joset A Etzel ... Jeffrey M Zacks
    The brain uses separate prediction error and prediction uncertainty signals to trigger event boundaries.
    1. Neuroscience

    Development of auditory and spontaneous movement responses to music over the first postnatal year

    Trinh Nguyen, Félix Bigand ... Giacomo Novembre
    Although auditory encoding of music is robust early in infancy, the transformation of this input into movement patterns develops substantially over the first postnatal year, without reaching full maturity.