Glycolytic activation directly drives Kupffer cell loss in early metabolic dysfunction-associated steatotic liver disease, highlighting a targetable metabolic vulnerability.
Shoubhik Chandan Banerjee, Fritz A Francisco, Albert B Kao
A navigational model exploring social learning strategies differing in cognitive complexity in homing pigeons shows that simple averaging sufficiently explains collective route improvements, without requiring cumulative cultural evolution.
Sarah Nicholas, Katja Sporar Klinge ... Karin Nordström
Descending neurons that encode widefield motion vision in the fly have sexually dimorphic velocity tuning, while the wing beat amplitude, which these neurons presumably control, is monomorphic.
Dominic Rebindaine, Thomas W Crowther ... Constantin M Zohner
Faster early-season development, especially under nighttime warming, advances the point at which the autumn phenology of European beech becomes responsive to late-summer cooling.
Gustavo Aguilar, Michèle E Sickmann ... Martin Müller
Early enhancer logic precisely aligns developmental boundaries by integrating HOX, GATA, and signaling inputs, ensuring correct tissue patterning and preventing mirror-image duplications in the developing wing.
The optimized protocol for isolating small extracellular vesicles from small blood volumes, confirmed by independent methods including cryo-electron microscopy, ensures superior purity and high yield for reliable biomarker detection.
Dana MS Cheung, Momchil Razsolkov ... J Simon C Arthur
B cell activation and antibody class switching requires coordinated metabolic rewiring, with essential roles for amino acid transport, cholesterol metabolism, and prenylation in driving proliferation across multiple activating stimuli.
Alina-Măriuca Marinescu, Eshita Kamal ... Marie A Labouesse
Within the nucleus accumbens shell, a spatially defined rostral subregion selectively modulates hedonic feeding, revealing functional heterogeneity in reward circuitry underlying food consumption.
