Browse our Research Articles

Page 3 of 1,476
    1. Structural Biology and Molecular Biophysics

    Active regulation of the epidermal growth factor receptor by the membrane bilayer

    Shwetha Srinivasan, Xingcheng Lin ... Gabriela S Schlau-Cohen
    Membrane composition modulates EGFR conformational dynamics and signaling, revealing that the bilayer properties can override ligand control to influence receptor activation in health and disease.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of Mycobacterium tuberculosis antigens

    Se-Jin Kim, Jessie C Peterson ... David Lewinsohn
    Synaptotagmin 1 and Synaptotagmin 7 promote MAIT cell activation during Mycobacterium tuberculosis infection by facilitating MR1 trafficking and antigen presentation.
    1. Physics of Living Systems

    Enhanced bacterial chemotaxis in confined microchannels occurs at lane widths matching circular swimming radius

    Caijuan Yue, Chi Zhang ... Junhua Yuan
    Geometric confinement paradoxically enhances bacterial chemotaxis through chiral surface swimming and sidewall alignment, with optimal performance when lane width matches the circular swimming radius.
    1. Cell Biology

    Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch

    Shivam Shukla, Jessica A Cross ... Mark P Dodding
    Cargo-adaptor binding to the KLC-TPR domains binding triggers structural rearrangements that relieve kinesin-1 autoinhibition, enabling MAP7 recruitment, through an allosteric mechanism that connects cargo recognition to motor activation.
    1. Genetics and Genomics
    2. Physics of Living Systems

    Revealing global stoichiometry conservation architecture in cells from Raman spectral patterns

    Ken-ichiro F Kamei, Koseki J Kobayashi-Kirschvink ... Yuichi Wakamoto
    Conservation levels of gene expression abundance ratios are globally coordinated in cells, and cellular state changes under such biologically relevant stoichiometric constraints are readable as low-dimensional changes in Raman spectra.
    1. Neuroscience

    Individuality across environmental context in Drosophila melanogaster

    Thomas F Mathejczyk, Cara Knief ... Gerit A Linneweber
    Environmental differences alter behavioral performance in Drosophila melanogaster without eliminating consistent individual differences.
    1. Neuroscience

    Audiovisual cues must be predictable and win-paired to drive risky choice

    Brett A Hathaway, Dexter R Kim ... Catharine Winstanley
    Sensory cues increase risky choice when paired with wins but reduce risky choice when paired with losses, with parallel shifts in sensitivity to negative outcomes.
    1. Neuroscience

    Stimulus dependencies—rather than next-word prediction—can explain pre-onset brain encoding in naturalistic listening designs

    Inés Schönmann, Jakub Szewczyk ... Micha Heilbron
    The ability to predict brain activity from words before they occur can be explained by information shared between neighbouring words, without requiring next-word prediction by the brain.
    1. Immunology and Inflammation

    Contrasting roles for IKK-regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive γδ T cells

    Farjana Islam, Cayman Williams ... Benedict Seddon
    Inhibitor of κB kinase signalling differentially controls development and survival of γδ T cell subsets through nuclear factor-κB activation and repression of receptor-interacting protein kinase 1-driven necroptosis, revealing distinct inflammatory signalling requirements from αβ T cells.