Browse our Research Articles

A unified structural model of IRE1 activation reconciles conflicting sensing theories by characterizing specific peptide-binding sites and the mechanism by which BiP regulates oligomerization during the unfolded protein response.

Through low levels of extracellular ATP, EPEC induces small, rapid and coordinated Ca²⁺ responses in epithelial cells, a yet unreported pattern, that down-regulate inflammation at the onset of infection.

Humans adapt learning rates on both a fast and a slow time scale, and the central orbitofrontal cortex may represent the slow time scale.

A computational pipeline leverages mammalian heart development videos to extract tissue deformation patterns and generate a virtual fate map tool that provides new insights into cardiac morphogenesis.

High-resolution single-cell transcriptomics reveals the molecular programs and signaling networks driving Schlemm's canal and trabecular meshwork development, establishing a foundation for understanding glaucoma pathogenesis.

Across three global Escherichia coli regulators, identical starting sequences can evolve toward many distinct strong-binding peaks, with chance, historical contingency, and evolutionary bias shaping which outcomes prevail.

Antibiotics that inhibit translation cause a burst in reactive oxygen species, and these must be detoxified by factors such as KatG for cells to survive.

Explaining the neural mechanisms underlying language-based, spontaneous categorization of visual words of alphabetic and non-alphabetic languages by combining electroencephalography, magnetoencephalography, and a repetition suppression paradigm.

Serotonin promotes a sleep-independent quiescent state through selective modulation of motor neural population dynamics.

A single temporal integration process links momentary perceptual biases to the generalization of learned skills, providing a unifying account of specificity versus flexibility in human learning.