Browse our Research Articles

A comprehensive mutational scan of TYK2 identifies novel allosteric sites, elucidates functional drug-protein interactions, and links autoimmune disease protection to reduced TYK2 protein abundance.

Altered tactile decision-making in autism reflects context-dependent weighting of sensory inputs and diminished integration of sensory history, enhancing low-salience discrimination while reducing category-based perceptual facilitation.

Cellular sensitivity to cell death stimuli depends on cell-size-dependent proteome changes - specifically, cell size can modulate ferroptosis susceptibility through changes in glutathione biosynthetic enzymes, ferritin, and cathepsin B concentrations.

A generic strategy for producing functional snake venom metalloproteinases opens the field to reproducible mechanistic studies and inhibitor discovery.

Non-covalent targeting of KEAP1 by capsaicin provides a reversible and safe NRF2 agonist for treating oxidative damage.

Dynamic relocalization of MinD in Bacillus subtilis arises from membrane binding of monomers and dimers with membrane-triggered ATP hydrolysis, suggesting MinE-like activators are unnecessary for Min system dynamics.

Arousal signals are present in the superior colliculus but appear to be organized in a way that they avoid directly triggering motor plans that lead to saccades.

Using macroevolution, species not strains, uncovered important diversity in how mycobacteria respond to and resist antibiotics, revealing novel resistance determinants.

Integrative structural analysis identifies the structural basis and key residues responsible for IDE conformational dynamics that control the unfolding and selective degradation of amyloid peptides.

Muscarinic cholinergic signaling links neural activity to organism‑wide transcriptional and proteostatic responses that protect against chronic oxidative stress.