Browse our Research Articles

Page 3 of 1,501
    1. Microbiology and Infectious Disease

    Reactive oxygen detoxification contributes to Mycobacterium abscessus antibiotic survival

    Nicholas A Bates, Ronald Rodriguez ... Bennett H Penn
    Antibiotics that inhibit translation cause a burst in reactive oxygen species, and these must be detoxified by factors such as KatG for cells to survive.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The adaptive landscapes of three global Escherichia coli transcriptional regulators

    Cauã Antunes Westmann, Leander Goldbach, Andreas Wagner
    Across three global Escherichia coli regulators, identical starting sequences can evolve toward many distinct strong-binding peaks, with chance, historical contingency, and evolutionary bias shaping which outcomes prevail.
    1. Developmental Biology

    Single-cell characterization of anterior segment development in the mouse reveals the cell types, pathways, and signals driving formation of the trabecular meshwork and Schlemm’s canal

    Revathi Balasubramanian, Nicholas Tolman ... Simon WM John
    High-resolution single-cell transcriptomics reveals the molecular programs and signaling networks driving Schlemm's canal and trabecular meshwork development, establishing a foundation for understanding glaucoma pathogenesis.
    1. Computational and Systems Biology
    2. Developmental Biology

    Quantitative computerized analysis demonstrates strongly compartmentalized tissue deformation patterns underlying mammalian heart tube formation

    Morena Raiola, Miquel Sendra Sendra ... Miguel Torres
    A computational pipeline leverages mammalian heart development videos to extract tissue deformation patterns and generate a virtual fate map tool that provides new insights into cardiac morphogenesis.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    RNA selectively modulates activity of virulent amyloid PSMα3 and host-defense LL-37 via phase separation and aggregation dynamics

    Bader Rayan, Eilon Barnea ... Meytal Landau
    RNA differentially regulates the assembly pathways of bacterial and host α-helical peptides, revealing supramolecular architecture as a tunable determinant of cytotoxic and antimicrobial function.
    1. Cell Biology
    2. Neuroscience

    FMRP regulates neuronal RNA granules containing stalled ribosomes, not where ribosomes stall

    Jewel T-Y Li, Mehdi Amiri ... Wayne S Sossin
    The loss of FMRP does not affect how neuronal ribosomes are stalled or where they are stalled, but reduces the number of neuronal RNA granules that contain stalled ribosomes.
    1. Neuroscience

    Organization of circuits linking descending input to motor output in the Drosophila Male Adult Nerve Cord connectome

    Han SJ Cheong, Katharina Eichler ... Gwyneth M Card
    Circuit analyses of synaptic connectivity in networks connecting descending and motor neurons in the Drosophila Male Adult Nerve Cord connectome reveal the modular network organization of descending to motor pathways.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2, and -3

    Crystal R Noell, Tzu-Chen Ma ... William O Hancock
    All three kinesin transport families exhibit unexpectedly slow dissociation under load, explaining robust competition with dynein during bidirectional cargo transport.
    1. Neuroscience

    Neural categorization of visual words of alphabetic and non-alphabetic languages

    Guo Zheng, Shihui Han
    Explaining the neural mechanisms underlying language-based, spontaneous categorization of visual words of alphabetic and non-alphabetic languages by combining electroencephalography, magnetoencephalography, and a repetition suppression paradigm.
    1. Neuroscience

    Serial dependence predicts generalization in perceptual learning

    Noga Pinchuk-Yacobi, Dov Sagi, Yoram S Bonneh
    A single temporal integration process links momentary perceptual biases to the generalization of learned skills, providing a unifying account of specificity versus flexibility in human learning.