Browse our Research Articles

A unified structural model of IRE1 activation reconciles conflicting sensing theories by characterizing specific peptide-binding sites and the mechanism by which BiP regulates oligomerization during the unfolded protein response.

Humans adapt learning rates on both a fast and a slow time scale, and the central orbitofrontal cortex may represent the slow time scale.

Through low levels of extracellular ATP, EPEC induces small, rapid and coordinated Ca²⁺ responses in epithelial cells, a yet unreported pattern, that down-regulate inflammation at the onset of infection.

Antibiotics that inhibit translation cause a burst in reactive oxygen species, and these must be detoxified by factors such as KatG for cells to survive.

Across three global Escherichia coli regulators, identical starting sequences can evolve toward many distinct strong-binding peaks, with chance, historical contingency, and evolutionary bias shaping which outcomes prevail.

A computational pipeline leverages mammalian heart development videos to extract tissue deformation patterns and generate a virtual fate map tool that provides new insights into cardiac morphogenesis.

High-resolution single-cell transcriptomics reveals the molecular programs and signaling networks driving Schlemm's canal and trabecular meshwork development, establishing a foundation for understanding glaucoma pathogenesis.

Explaining the neural mechanisms underlying language-based, spontaneous categorization of visual words of alphabetic and non-alphabetic languages by combining electroencephalography, magnetoencephalography, and a repetition suppression paradigm.

Poor paternal nutrition at the time of conception shapes post-fertilisation developmental trajectory, fetal growth, and placental dynamics.

In a polymer model of chromatin that explicitly incorporates different types of transcription factors, both specialised and mixed factories emerge naturally, with their composition governed by their size.