Browse our Research Articles

Heterogeneity in outcomes of differently located activating mutations of Notch indicates the need and potential for mutant specific targeting of Notch in cancer.

Probiotic communities designed to inhibit a lung pathogen through niche exclusion show promise as a novel method of preventing respiratory infection.

Genetic influences on how the brain processes complex naturalistic stimuli can be traced back to inherited control over stable spatial and temporal features of brain function.

DNA-methylation-based predictors of biological age often fail to generalize across human populations, limiting their utility as biomarkers of aging and disease.

Leiomodin 1 acts as a critical molecular switch during early muscle stem cell differentiation by sequestering the deacetylase SIRT1 in the cytoplasm to initiate the myogenic program.

Prolonged oxycodone abstinence strengthens paraventricular thalamus to nucleus accumbens shell glutamatergic transmission in both sexes, yet only females show enhanced relapse, dissociating shared synaptic plasticity from sex-specific relapse vulnerability.

Gene dosage imbalance due to the triplication of human chromosome 21 gene orthologs impairs whole-body glucose and lipid metabolism by disrupting homeostatic processes across major metabolic tissues.

Re-engineering a highly conserved metabolic pathway in yeast prevents age-related functional decline and proves that ageing is not inevitably linked to loss of fitness.

Hidden outward-facing intermediates and long-lived ATP-bound states reveal how ATP binding drives conformational dynamics in the heterodimeric ABC transporter TmrAB.

Despite the variation in venom across the Bothrops snake genus, repurposed drugs demonstrated pan-species neutralisation in enzymatic, coagulation, and haemorrhage assays, highlighting their value as novel therapies for Neotropical snakebites.