Browse our Research Articles

Page 3 of 1,497
    1. Immunology and Inflammation

    TGF-β drives the conversion of conventional NK cells into uterine tissue-resident NK cells to support murine pregnancy

    Josselyn D Barahona, Liping Yang ... Wayne M Yokoyama
    Uterine natural killer (NK) cells require TGF-β to be derived from conventional NK cells and contribute to successful pregnancy.
    1. Neuroscience

    Medial prefrontal cortex encodes but is not required to generate goal-directed actions under threat

    Muhammad S Sajid, Ji Zhou, Manuel A Castro-Alamancos
    Medial prefrontal cortex activity is not required for learning or execution of adaptive avoidance behavior, despite encoding select task features.
    1. Genetics and Genomics

    Autosomal allelic inactivation at loci with variable replication timing and dosage sensitivity

    Michael B Heskett, Athanasios E Vouzas ... Mathew J Thayer
    Stable allele-specific epigenetic regulation creates cellular mosaicism of numerous autosomal dosage-sensitive genes involved in human neurological and developmental disorders.
    1. Structural Biology and Molecular Biophysics

    Lenacapavir-induced lattice hyperstabilization is central to HIV-1 capsid failure at the nuclear pore complex and in the cytoplasm

    Arpa Hudait, Ryan C Burdick ... Gregory A Voth
    Lenacapavir disrupts HIV-1 capsid elasticity, inducing mechanical rupture at the nuclear pore, highlighting that altering viral material properties can be a viable antiviral drug design strategy.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Canonical and phosphoribosyl ubiquitination coordinate to stabilize a proteinaceous structure surrounding the Legionella-containing vacuole

    Adriana Steinbach, Chetan Mokkapati ... Shaeri Mukherjee
    Two families of ubiquitin ligases secreted by the intracellular pathogen Legionella pneumophila utilize distinct chemistries to form a stable, ubiquitin-rich structure around the vacuole, which is subsequently disassembled as infection progresses.
    1. Chromosomes and Gene Expression

    Impacts of DNA methylation on H2A.Z deposition and nucleosome stability

    Rochelle M Shih, Yasuhiro Arimura ... Hironori Funabiki
    DNA methylation suppresses H2A.Z deposition by inhibiting recruitment of the chaperone SRCAP, while the structural study suggests that methylated DNA can make the H2A.Z nucleosome slightly more accessible.
    1. Chromosomes and Gene Expression

    Ligand-dependent enhancer activation indirectly modulates non-target promoters in a chromatin domain

    Darshika Bohra, Zubairul Islam ... Dimple Notani
    Ligand-driven enhancer activation selectively boosts target gene expression while indirectly repressing neighboring non-target genes, revealing dynamic and competitive regulation during early transcriptional responses.
    1. Neuroscience

    Multiple event segmentation mechanisms in the human brain

    Tan T Nguyen, Joset A Etzel ... Jeffrey M Zacks
    The brain uses separate prediction error and prediction uncertainty signals to trigger event boundaries.
    1. Genetics and Genomics

    Optimised genome editing for precise DNA insertion and substitution using prime editors in zebrafish

    Yosuke Ono, Martin Peterka ... Steffen Scholpp
    Nickase and nuclease Prime Editors offer complementary routes for precise zebrafish genome editing, balancing accuracy for substitutions with efficiency for short insertions.
    1. Neuroscience

    Development of auditory and spontaneous movement responses to music over the first postnatal year

    Trinh Nguyen, Félix Bigand ... Giacomo Novembre
    Although auditory encoding of music is robust early in infancy, the transformation of this input into movement patterns develops substantially over the first postnatal year, without reaching full maturity.