Browse our Research Articles

Page 3 of 1,496
    1. Neuroscience

    Multiple event segmentation mechanisms in the human brain

    Tan T Nguyen, Joset A Etzel ... Jeffrey M Zacks
    The brain uses separate prediction error and prediction uncertainty signals to trigger event boundaries.
    1. Genetics and Genomics

    Optimised genome editing for precise DNA insertion and substitution using prime editors in zebrafish

    Yosuke Ono, Martin Peterka ... Steffen Scholpp
    Nickase and nuclease Prime Editors offer complementary routes for precise zebrafish genome editing, balancing accuracy for substitutions with efficiency for short insertions.
    1. Biochemistry and Chemical Biology

    Profiling of terminating ribosomes reveals translational control at stop codons

    Longfei Jia, Yuanhui Mao ... Shu-Bing Qian
    Systematic characterization of terminating ribosomes uncovers sequence features influencing ribosome dynamics at stop codons with direct implications in 3' UTR translation.
    1. Neuroscience

    Development of auditory and spontaneous movement responses to music over the first postnatal year

    Trinh Nguyen, Félix Bigand ... Giacomo Novembre
    Although auditory encoding of music is robust early in infancy, the transformation of this input into movement patterns develops substantially over the first postnatal year, without reaching full maturity.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Pervasive relaxed selection on spermatogenesis genes coincident with the evolution of polygyny in gorillas

    Jacob D Bowman, Neide Silva ... Vincent J Lynch
    Genes associated with male reproductive biology appear to be under relaxed selective constraint in a primate species with low sperm competition.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Arrayed single-gene perturbations identify drivers of human anterior neural tube closure

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    A method for arrayed CRISPRi screening in organoids enables the investigation of morphogenesis in human stem cell-derived tissues, revealing the roles of ZIC2, SOX11, and ZNF521 in neural tube closure.
    1. Cell Biology
    2. Genetics and Genomics

    Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival

    Serhiy Havrylov, Armin M Gamper, Ordan J Lehmann
    Genetic experiments integrated with ChIP-sequencing and CRISPR interference reveal that overexpression of Foxc1 transcriptionally activates the expression of Arhgap36 and dysregulates multiple facets of Hedgehog pathway activity.
    1. Cell Biology
    2. Neuroscience

    Activity-dependent CO2 production in the axon triggers opening of Connexin32 in the Schwann cell paranode

    Jack Butler, Lowell Mott ... Nicholas Dale
    Gaseous CO2 acts as a neuron to glia messenger in peripheral myelin to trigger opening of Schwann Cell Cx32 hemichannels in response to axonal action potential propagation.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    A coma pattern-based autofocusing method resolves bacterial cold shock response at single-cell level

    Sihong Li, Zhixin Ma ... Shuqiang Huang
    A robust autofocusing method enables continuous single-cell imaging during rapid cooling, revealing sustained bacterial proliferation hidden by growth arrest inferred from optical-density measurements.
    1. Cell Biology
    2. Computational and Systems Biology

    Lipid packing contributes to the confinement of caveolae to the plasma membrane

    Elin Larsson, Aleksei Kabedev ... Richard Lundmark
    Membrane insertion of Dyngo-4a results in a dynamin-independent inhibition of caveola dynamics, revealing that outer leaflet lipid packing in the plasma membrane contributes to the confinement of caveolae.