Browse our Research Articles

Titin-associated muscle ankyrin repeat proteins limit stretch-induced longitudinal muscle hypertrophy and link titin mechanosensing to mTOR signaling.

A time-dependent genetic interaction between the µ opioid receptor and genes drives early morphine responses in mice, highlighting pathways linked to human substance use disorder.

Gaze patterns during value-based choice may reflect post-decision processes rather than a direct causal influence of attention on preference formation.

Cholecystokinin release from CA3 inputs to CA1 links local excitatory circuitry to hippocampal plasticity and spatial memory.

MgIG directly targets HSD11B1 to alleviate alcohol-associated liver disease by suppressing the HSD11B1–SREBP2–IDI1 pathway, thereby reducing hepatic steatosis, inflammation, and apoptosis.

The brain computes rapidly and reliably using brief electrical impulses and likely exploits internal memory in nerve cells to achieve this more efficiently than existing computing hardware and neural networks.

TNF-driven metabolic reprogramming enhances glucose utilization in monocytes through inducible nitric oxide synthase (iNOS) and hypoxia-inducible factor 1α (HIF-1α), promoting parasite control and host resistance during Plasmodium infection.

Type I and type II inhibitors differentially affect LRRK2 filament formation around microtubules, revealing an important consideration for Parkinson’s disease drug development.

Flexible evidence accumulation in dynamic environments relies on multiple mechanisms, including context-dependent modulations of sensory adaptation and pupil-linked arousal.

Pathogens can use surface proteins to limit immune responses, and the finding that merozoite surface protein 2 has this property could help in Plasmodium falciparum malaria vaccine development.