Browse our Research Articles

Page 3 of 1,475
    1. Cell Biology

    GTPase-activating protein DLC1 spatio-temporally regulates Rho signaling

    Lucien Hinderling, Max Heydasch ... Olivier Pertz
    Mechanosensitive recruitment of DLC1 to focal adhesions creates a positive feedback loop that locally amplifies Rho activation in response to tension.
    1. Neuroscience

    Stimulus dependencies—rather than next-word prediction—can explain pre-onset brain encoding in naturalistic listening designs

    Inés Schönmann, Jakub Szewczyk ... Micha Heilbron
    The ability to predict brain activity from words before they occur can be explained by information shared between neighbouring words, without requiring next-word prediction by the brain.
    1. Neuroscience

    Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

    Kevin C Lister, Calvin Wong ... Arkady Khoutorsky
    Spinal translational control mechanisms regulate gene expression and nociceptive circuit sensitization during the chronic phase of neuropathic pain.
    1. Immunology and Inflammation

    Contrasting roles for IKK-regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive γδ T cells

    Farjana Islam, Cayman Williams ... Benedict Seddon
    Inhibitor of κB kinase signalling differentially controls development and survival of γδ T cell subsets through nuclear factor-κB activation and repression of receptor-interacting protein kinase 1-driven necroptosis, revealing distinct inflammatory signalling requirements from αβ T cells.
    1. Neuroscience

    Challenges in replay detection by TDLM in post-encoding resting state

    Simon Kern, Juliane Nagel ... Gordon B Feld
    Detecting replay during longer time periods (e.g. resting state or sleep) with temporally delayed linear modeling (TDLM) requires biologically implausible event densities, and purely synthetic simulations substantially overestimate the method's sensitivity.
    1. Neuroscience

    The dominance of large-scale phase dynamics in human cortex, from delta to gamma

    David M Alexander, Laura Dugué
    The phase of cortical activity, measured in the gray matter, is organized at multiple spatial scales, with the largest scales explaining most variance in phase at a given temporal frequency.
    1. Cell Biology

    Specialisation of meiotic kinetochores revealed through a synthetic spindle assembly checkpoint strategy

    Lori B Koch, Tiasha Ghosh ... Adèle L Marston
    A system to enrich yeast in metaphase of mitosis, meiosis I, or meiosis II reveals reduced spindle assembly checkpoint robustness in meiosis I and distinct kinetochore composition and phosphorylation states.
    1. Structural Biology and Molecular Biophysics

    A structural code for assembly specificity in GID/CTLH-type E3 ligases

    Pia Maria van gen Hassend, Hermann Schindelin
    Structural characterization of the CTLH-CRA domain-mediated pairing in the CTLH ubiquitin ligase complex enables rational engineering of interfaces with altered binding specificity.
    1. Ecology
    2. Evolutionary Biology

    Fitness drivers of division of labor in vertebrates

    Irene García-Ruiz, Dustin R Rubenstein
    Direct survival benefits in larger groups rather than kin-selected indirect fitness primarily drive the evolution of division of labor in cooperatively breeding vertebrates, particularly under harsh environmental conditions.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Identification and comparison of orthologous cell types from primate embryoid bodies shows limits of marker gene transferability

    Jessica Jocher, Philipp Janssen ... Ines Hellmann
    Analysis of scRNA-seq data from primate embryoid bodies highlights the value of cross-species comparisons for identifying and characterizing cell types, as marker genes can evolve fast.