Browse our Research Articles

Magnetically steered mesenchymal stem cells significantly lowered intraocular pressure for 9 months in mice, motivating the translation of this technology for the treatment of glaucoma.

CHMP5 is crucial in preventing skeletal progenitor cell senescence and abnormal bone formation, and senolytic drugs represent potential therapeutic medicine for musculoskeletal abnormalities associated with a dysfunctional endolysosomal pathway.

Dual regulation of TORC1 by Gtr1/2 and Pib2 drives cells into three distinct signaling states, establishing a new paradigm for graded TORC1 signaling.

Parasitic tapeworm larvae release glutamate and other excitatory molecules that can directly excite brain neurons.

A biphasic structural plasticity rule interacts with homeostatic synaptic scaling to maintain firing rate homeostasis in neural networks.

Imaging deep root tissues with a combination of cell-cycle reporters reveals that a cortical cell file traversed by symbiotic bacteria exhibits reduced proliferative potential and enters a prolonged G2 phase.

Hamlet regulates heterotypic epithelial fusion by controlling spatial and temporal expression of known and novel epithelial regulators like Wnt and Tl pathway components, a mechanism potentially conserved through evolution.

The neuropeptide galanin modulates whole-brain activity and stress responses in zebrafish, revealing a complex, receptor-dependent role in seizure regulation with implications for epilepsy, and related neurological disorders.

Through the destabilization of CIITA, the human cytomegalovirus-encoded protein pUS28 antagonizes the expression of the HLA-II molecules CD74/Ii, HLA-DR, HLA-DQ, HLA-DM, and HLA-DP, diminishing the activation of HCMV-specific CD4+ T cells and reducing their secretion of antiviral cytokines.

A new computational model improves estimation of Granger connectivity by removing spurious effects of external inputs, and estimation of linear encoding models by removing spurious effects of recurrent connections.