Cryo-EM structures unexpectedly show that there are two binding sites for RAB5, with the VPS15 site being the most evolutionarily ancient site, which is essential for endocytic sorting.
Simone Daniela Rencken, Georgi Tushev ... Gilles Laurent
A chromosome-scale, annotated reference genome for the common cuttlefish Sepia officinalis clarifies its karyotype and reveals cephalopod-specific gene family expansions across neural and non-neural tissues.
Thomas Moss, Alexandra Wooldredge ... Shaeri Mukherjee
A phosphorylation site on Hsp70 previously linked to pathogen activity functions endogenously in DNA damage responses and connects chaperone regulation to cell cycle control.
Hearing impairment selectively disrupts neural tracking of speech at both short and long temporal scales during multi-speaker listening, while preserving intermediate linguistic processing.
BRCA1/2 mutations rewire the lung adenocarcinoma microenvironment through distinct immune programs, with BRCA1-linked type I interferon signaling and CD8+ T activation contrasting BRCA2-linked MHC-II antigen presentation and CD4+ T differentiation.
Shoubhik Chandan Banerjee, Fritz A Francisco, Albert B Kao
A navigational model exploring social learning strategies differing in cognitive complexity in homing pigeons shows that simple averaging sufficiently explains collective route improvements, without requiring cumulative cultural evolution.
Glycolytic activation directly drives Kupffer cell loss in early metabolic dysfunction-associated steatotic liver disease, highlighting a targetable metabolic vulnerability.
Dominic Rebindaine, Thomas W Crowther ... Constantin M Zohner
Faster early-season development, especially under nighttime warming, advances the point at which the autumn phenology of European beech becomes responsive to late-summer cooling.