Stephania Assimopoulos, Shaun Warrington ... Stamatios N Sotiropoulos
By providing new ways to map cortico-subcortical connectivity patterns, the proposed cross-species tractography approaches directly allow novel comparative studies between the human and macaque brain and enable subsequent explorations of brain-behaviour/disease symptom associations across individuals.
Nirujan Rameshkumar, Abhishek P Shrestha ... Thirumalini Vaithianathan
Calcium levels and structural diversity among synaptic ribbons in bipolar neurons likely enable differential encoding of visual information, revealing a potential mechanism for fine-tuning sensory signal processing.
Samuel Bru, Lydie Michaillat Mayer ... Andreas Mayer
In vitro reconstitution identifies how lysosome-related vacuoles coordinate the synthesis and turnover of inorganic polyphosphates to create a powerful buffer system stabilising a vital metabolic parameter, the cytosolic concentration of phosphate.
Sarah G Donofrio, Cheryl Brandenburg ... Roy V Sillitoe
Purkinje cell subpopulations have varying vulnerability to age-related neurodegeneration, creating a striped pattern of cell loss that reflects the developmental, anatomical, and functional organization of the cerebellum.
A normative computational model of individual differences in mouse exploration driven by reward and threat uncertainty as well as risk sensitivity when faced with a novel object in an open field.
Ramesh Chittajallu, Anna Vlachos ... Chris J McBain
A pharmacogenetic approach provides a foundational dataset describing the influence of opioids on synaptic processing in a brain microcircuit known to be critical for driving hedonic behaviors.
Restitution of RAP2A, human homolog of Drosophila asymmetric cell division regulator Rap2l, in glioblastoma neurosphere cultures targets the stemness of glioblastoma stem cells and could contribute to reduce glioblastoma expansion.
