Browse our Research Articles

Page 3 of 1,449
    1. Developmental Biology
    2. Genetics and Genomics

    Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically diverse Caenorhabditis nematodes

    Stephen A Banse, Christine A Sedore ... Patrick C Phillips
    Computer screening identifies that the widely prescribed vitamin A derivative all-trans retinoic acid increases both longevity and late-life health in a powerful genetic model system.
    1. Neuroscience

    Regional heterogeneities of oligodendrocytes underlie biased Ranvier node spacing along single axons in sound localization circuit

    Ryo Egawa, Kota Hiraga ... Hiroshi Kuba
    Oligodendrocytes with different morphological features work together to support precise binaural integration for sound localization in the chick brainstem auditory circuit.
    1. Developmental Biology

    Mac-/Lactosylceramide regulates intestinal homeostasis and secretory cell fate commitment by facilitating Notch signaling

    Kebei Tang, Xuewen Li ... Rongwen Xi
    An evolutionarily conserved glycosphingolipid metabolite ensures precise stem cell fate decisions by modulating Delta-Notch signaling dynamics.
    1. Evolutionary Biology

    Cryptovaranoides is not a squamate

    Michael W Caldwell, Chase D Brownstein ... Tiago R Simões
    Claims for a Triassic-aged crown lizard merit detailed reanalysis, the results of which find that Cryptovaranoides is not only not a lizard, but is a more distantly related diapsid reptile.
    1. Neuroscience

    Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

    Yanshu Wang, Amir Rattner ... Jeremy Nathans
    In mice, loss of TGF-beta signaling specifically in vascular endothelial cells leads to retinal hypovascularization, choroidal neovascularization, a pro-inflammatory state within brain and retinal endothelial cells, and an influx of diverse inflammatory cells into the retina.
    1. Medicine

    Are peer reviewers influenced by their work being cited?

    Adrian Barnett
    Some requests by reviewers to cite their own publications are coercive and can unnecessarily delay indexation and publication.
    1. Microbiology and Infectious Disease

    Functional genomics reveals strain-specific genetic requirements conferring hypoxic growth in Mycobacterium intracellulare

    Yoshitaka Tateishi, Yuriko Ozeki ... Sohkichi Matsumoto
    Transposon sequencing analyses reveal that among genomically diverse clinical Mycobacterium intracellulare strains and the type strain, 131 genes were comprehensively identified as universal essential genes suggesting promising drug targets.
    1. Neuroscience

    Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex

    Abby Silbaugh, Kevin P Koster, Christian Hansel
    Optogenetic climbing fiber activation regulates experience-dependent plasticity in the primary somatosensory cortex of mice, suggesting a role of the olivo-cerebellum in instructive signaling across brain regions.
    1. Neuroscience

    Cone bipolar cell synapses generate transient versus sustained signals in parallel ON pathways of the mouse retina

    Sidney P Kuo, Wan-Qing Yu ... Fred Rieke
    Differences in kinetics of retinal output signals originate at least in part from differences in synaptic output from distinct bipolar cell types.