Browse our Research Articles

Page 3 of 1,499
    1. Cancer Biology
    2. Cell Biology

    DuoHexaBody-CD37 induces direct cytotoxic signaling in diffuse large B-cell lymphoma

    Simar Pal Singh, Kumar Mangalam ... Annemiek B van Spriel
    DuoHexaBody‑CD37 triggers complement‑independent cytotoxic signaling in diffuse large B-cell lymphoma (DLBCL), revealing therapeutic pathways that can be exploited to enhance tumor cell killing through targeted combination strategies.
    1. Neuroscience

    Neural categorization of visual words of alphabetic and non-alphabetic languages

    Guo Zheng, Shihui Han
    Explaining the neural mechanisms underlying language-based, spontaneous categorization of visual words of alphabetic and non-alphabetic languages by combining electroencephalography, magnetoencephalography, and a repetition suppression paradigm.
    1. Neuroscience

    The effect of physical activity on brain structure and cognitive function in the population-based cohort of LIFE-Adult Study

    Polona Kalc, Robert Dahnke ... Christian Gaser
    Although physical exercise could be a beneficial protective factor for brain health in later life, older adults tend to overestimate their actual levels of activity.
    1. Epidemiology and Global Health

    A natural experiment in Kenya reveals durable immunosuppressive effects of early childhood malaria: a longitudinal cohort study

    Mercy S Safari, Timothy O Makori ... Charles J Sande
    Early-life malaria exposure leaves a durable immunological imprint associated with reduced antibody responses to unrelated infections and vaccines.
    1. Chromosomes and Gene Expression

    Linking germline telomere removal to global programmed DNA elimination in Tetrahymena genome differentiation

    Kohei Nagao, Alix Lemoine ... Kazufumi Mochizuki
    Tetrahymena germline chromosome ends contain germline-limited sequences that are removed by chromosome breakage, a critical step for programmed DNA elimination of other germline-limited sequences and successful sexual reproduction.
    1. Structural Biology and Molecular Biophysics

    In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies

    Yanqing Yang, Lulu Qiao ... Ruhong Zhou
    Computer-Aided Aptamer Modeling and Optimization (CAAMO) enables structure-guided RNA aptamer affinity maturation, producing a SARS-CoV-2 RBD (receptor binding domain) binder that rivals neutralizing antibodies and retains predicted activity across variants.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Experimental verification of the error minimization theory using non-standard genetic codes constructed in vitro

    Ryota Miyachi, Norikazu Ichihashi
    The in vitro experiments that used the artificial genetic codes tested here did not provide support for the error minimization theory.
    1. Cell Biology

    Cytoplasmic circular dsDNA is a key constituent of stress granules

    Natalia A Demeshkina, Adrian R Ferré-D'Amaré
    Extrachromosomal circular DNA has been identified as a novel component of stress granule cores, indicating its essential involvement in eukaryotic stress response pathways at the level of protein synthesis.
    1. Neuroscience

    Human cerebellum and ventral tegmental area interact during extinction of learned fear

    Enzo Nio, Patrick Pais Pereira ... Dagmar Timmann
    The cerebellum and ventral tegmental area interact during unexpected omissions of aversive outcomes in humans, supporting a role for reward-like prediction error signaling in fear extinction learning.
    1. Neuroscience

    Anterior cingulate cortex monitors action state and action content in complex associative learning

    Wenqiang Huang, Arron F Hall ... Dong V Wang
    ACC contains specialized neurons that sustain rich action-relevant information after action execution, enabling prolonged action monitoring, and supporting complex associative linking across events.