Browse our Research Articles

Page 3 of 1,463
    1. Evolutionary Biology

    On the nature of the earliest known lifeforms

    Dheeraj Kanaparthi, Frances Westall ... Tillmann Lueders
    Microfossils reported from Archaean BIFs most likely were liposome-like protocells, which had evolved intracellular mechanisms for energy conservation but not for regulating cell morphology and replication.
    1. Computational and Systems Biology
    2. Neuroscience

    Deep neural networks to register and annotate cells in moving and deforming nervous systems

    Adam A Atanas, Alicia Kun-Yang Lu ... Steven W Flavell
    New machine vision tools are used to align densely packed cells recorded from live, deforming tissues and automatically annotate the identities of the recorded cell types.
    1. Neuroscience

    A three-dimensional immunofluorescence atlas of the brain of the hackled-orb weaver spider, Uloborus diversus

    Gregory Artiushin, Abel Corver, Andrew Gordus
    A detailed annotation of anatomical brain structures (some novel) of the spider Uloborus diversus is provided based on a three-dimensional immunostain atlas.
    1. Microbiology and Infectious Disease

    Neutralizing human monoclonal antibodies that target the PcrV component of the type III secretion system of Pseudomonas aeruginosa act through distinct mechanisms

    Jean-Mathieu Desveaux, Eric Faudry ... Pascal Poignard
    Human antibodies isolated from cystic fibrosis patients against PscF and PcrV of the Pseudomonas aeruginosa Type 3 Secretion System reveal that anti-PcrV antibodies inhibit secretion through distinct mechanisms.
    1. Neuroscience

    Neural connectome of the ctenophore statocyst

    Kei Jokura, Sanja Jasek ... Gáspár Jékely
    Volume EM and connectome reconstruction of the apical organ of a ctenophore combined with high-speed imaging reveals a neuronal coordination of balancer cilia in the gravisensory organ.
    1. Neuroscience

    Spatially periodic computation in the entorhinal-hippocampal circuit during navigation

    Bo Zhang, Xin Guan ... Jia Liu
    A threefold hippocampal code across conceptual directions, phase-locked to entorhinal grid activity, reveals a periodic mechanism through which entorhinal grids structure hippocampal vector representations.
    1. Neuroscience

    Single molecule counting detects low-copy glycine receptors in hippocampal and striatal synapses

    Serena Camuso, Yana Vella ... Christian G Specht
    Synapses in the forebrain were thought of as purely GABAergic, yet they contain minute numbers of glycine receptors, often in the single digits.
    1. Genetics and Genomics

    SETDB1 enables development beyond cleavage stages by extinguishing the MERVL-driven two-cell totipotency transcriptional program in the mouse embryo

    Tie-Bo Zeng, Zhen Fu ... Piroska E Szabó
    Conditional genetics and single-embryo RNA-seq show that SETDB1 extinguishes the transient, retroelement-driven transcriptional programs of the totipotent two-cell state to facilitate the exit from totipotency and ensure preimplantation development.
    1. Neuroscience

    Frictional instabilities as an alternative to friction coefficient in fine touch perception

    Maryanne Derkaloustian, Pushpita Bhattacharyya ... Charles B Dhong
    To study fine touch, selecting samples based on how many mechanical instabilities they can form is more predictive than using the friction coefficient, which has been the default choice.