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Non-equilibrium thermodynamics allows signaling networks to signal downstream of certain ligands but avoid signaling from others.

Transcriptional responses to axonal damage are required for circuit repair, but these responses are restrained in injuries that leave spared axonal branches.

Routine genomic surveillance uncovered a decades-long multidrug-resistant Pseudomonas aeruginosa outbreak sustained by patient reservoirs and hospital plumbing, enabling targeted infection control measures that ultimately curtailed transmission.

Functional connectivity in rodent and human neuronal cultures is best explained by homophilic wiring rules, in which neurons preferentially form connections depending on spatial proximity and shared connectivity patterns, suggesting a unifying principle across scales.

A genetic tracing study demonstrates that neural progenitor lineage dominance may not be maintained in differentiated progeny, underscoring the critical need for region-specific markers to validate pluripotent stem cell–derived products.

Learning new navigation or memory skills engages flexible brain network dynamics without altering gray matter, white matter, or hippocampal structure.

While the genes involved in craniofacial development are highly conserved between the fat-tailed dunnart and mouse, their cis-regulatory elements show significant divergence and appear to reflect species-specific developmental processes.

Intermolecular steric repulsion generated by glycans on the cell membrane inhibits viral infection by preventing the formation of a virus-cell interface, regardless of the identity of molecules for glycan modification.

Despite major perturbations from sequential interventions, the Plasmodium falciparum population remained very large and retained the var population genetic characteristics of a high-transmission system.

Deep3DSIM enables super-resolution imaging >130 µm into complex tissues of fixed and live specimens in an upright configuration, allowing sample manipulation, as well as rapid refocusing without the need to move the specimen or objective lens.