Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based epigenome editing.
Linking biological research with disordered-systems modeling, providing new insights into gut microbiome stability, functioning, and their relationship with health.
J Ignacio Gutierrez, Claudia Edgar, Jessica K Tyler
Live imaging analyses in budding yeast reveal that calorie restriction and overexpression of the mRNA binding protein Ssd1 both block deleterious age-dependent iron uptake as a mechanism to extend lifespan.
Giulia Di Bartolomei, Raúl Ortiz ... Peter Scheiffele
An alternative splicing regulator previously implicated in calcium signaling in the heart ensures cell-type-specific mRNA processing of long neuronal mRNAs in the mouse brain.
Mathias Sablé-Meyer, Lucas Benjamin ... Stanislas Dehaene
fMRI and MEG results in adults and children show encoding of abstract geometric regularities in dorsal-parietal, temporal, and frontal regions, pointing to a system for symbolic geometric representation in humans.
Lipid imbalance triggered by Snail-driven epithelial–mesenchymal transition creates a cholesterol-dependent vulnerability that can be therapeutically targeted to overcome chemoresistance in cancer.
Single-molecule tracking of transcription factors in living cells revealed how mutations that make short activation domains stronger increased the fraction of transcription factor molecules bound to chromatin and led to longer residence times on chromatin.
Marta Chaverra, John Paul Toney ... R Steven Stowers
Drosophila internal male reproductive organs exhibit parallel innervation by two types of multi-transmitter neurons, a subset of which are essential for fertility, and organ-specific spatially discrete neurotransmitter receptor expression.
An affinity-guided chemical strategy enabling highly specific biotinylation of P2X7 receptors reveals, by super-resolution microscopy, how the nanoscale organization of endogenous P2X7 in BV2 microglial cells dynamically changes upon activation.
