Browse our Research Articles

Nickase and nuclease Prime Editors offer complementary routes for precise zebrafish genome editing, balancing accuracy for substitutions with efficiency for short insertions.

Although auditory encoding of music is robust early in infancy, the transformation of this input into movement patterns develops substantially over the first postnatal year, without reaching full maturity.

Ligand-driven enhancer activation selectively boosts target gene expression while indirectly repressing neighboring non-target genes, revealing dynamic and competitive regulation during early transcriptional responses.

The brain uses separate prediction error and prediction uncertainty signals to trigger event boundaries.

Systematic characterization of terminating ribosomes uncovers sequence features influencing ribosome dynamics at stop codons with direct implications in 3' UTR translation.

A method for arrayed CRISPRi screening in organoids enables the investigation of morphogenesis in human stem cell-derived tissues, revealing the roles of ZIC2, SOX11, and ZNF521 in neural tube closure.

DNA methylation suppresses H2A.Z deposition by inhibiting recruitment of the chaperone SRCAP, while the structural study suggests that methylated DNA can make the H2A.Z nucleosome slightly more accessible.

Membrane insertion of Dyngo-4a results in a dynamin-independent inhibition of caveola dynamics, revealing that outer leaflet lipid packing in the plasma membrane contributes to the confinement of caveolae.

Genetic experiments integrated with ChIP-sequencing and CRISPR interference reveal that overexpression of Foxc1 transcriptionally activates the expression of Arhgap36 and dysregulates multiple facets of Hedgehog pathway activity.

A robust autofocusing method enables continuous single-cell imaging during rapid cooling, revealing sustained bacterial proliferation hidden by growth arrest inferred from optical-density measurements.