Browse our Research Articles

Page 3 of 1,479
    1. Cell Biology

    Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow

    Jing-Xin Feng, Mei-Ting Yang ... Giovanna Tosato
    Single-cell and bulk lineage tracing reveals that adult bone marrow endothelial cells generate functional hematopoietic progenitor and mature blood cells, expanding the cell sources of postnatal hematopoiesis.
    1. Immunology and Inflammation

    B cell expression of an enzymatic intermediary in ether lipid biosynthesis promotes antibody responses and germinal center size

    Sung Hoon Cho, Marissa A Jones ... Mark R Boothby
    Genetic experiments combined with cellular and biochemical analyses including lipidomics performed by imaging mass spectrometry reveal that the capacity of mature B lymphocytes and germinal center B cells to synthesize some ether phospholipids is vital for normal humoral responses.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785

    Shan Zhang, Robyn Stix ... José D Faraldo-Gómez
    Computer simulations reveal the structural basis for a selective mechanism of ion-channel inhibition that could guide future pharmacological developments against associated human health disorders.
    1. Neuroscience

    AFD thermosensory neurons mediate tactile-dependent locomotion modulation in C. elegans

    Manuel Rosero, Jihong Bai
    The thermosensory neuron AFD unexpectedly modulates locomotion based on tactile experience through molecular and circuit mechanisms distinct from those underlying thermosensation.
    1. Neuroscience

    The dual molecular identity of vestibular kinocilia bridges structural and functional traits of primary and motile cilia

    Zhanhong Xu, Amirrasoul Tavakoli ... David Z He
    The kinocilium of vestibular hair cells is a unique organelle with molecular features of primary and motile cilia and may serve as an active, force-generating element within the hair bundle.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    The olfactory receptor SNIF-1 mediates foraging for leucine-enriched diets in C. elegans

    Ritika Siddiqui, Nikita Mehta ... Varsha Singh
    Behavioral analyses combined with genetics revealed that Caenorhabditis elegans uses an olfactory receptor-ligand module to forage for essential nutrients.
    1. Structural Biology and Molecular Biophysics

    SMC complex unidirectionally translocates DNA by coupling segment capture with an asymmetric kleisin path

    Masataka Yamauchi, Giovanni Bruno Brandani ... Shoji Takada
    An asymmetric kleisin path breaks the symmetry of the SMC homodimer, ensuring unidirectional DNA translocation via a segment capture mechanism.
    1. Neuroscience

    Multiple functions of cerebello-thalamic neurons in learning and offline consolidation of a motor skill in mice

    Andrés Pablo Varani, Caroline Mailhes-Hamon ... Daniela Popa
    Distinct cerebellar projections to the forebrain differentially support acquisition and offline consolidation of a motor skill engaging cerebello-striato-cortical circuits, revealing the temporal and functional diversity of cerebellar contributions to learning.
    1. Physics of Living Systems

    Colony demographics shape nest construction in Camponotus fellah ants

    Harikrishnan Rajendran, Roi Weinberger ... Ofer Feinerman
    The architecture of an ant nest serves as a fossilized record of the colony's demographic history, with distinct growth patterns and catastrophic events through age-specific digging behaviors.
    1. Cell Biology
    2. Immunology and Inflammation

    Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response

    Shiqiang Xu, Alix Buridant ... Henri-François Renard
    Endophilin-A3-mediated clathrin-independent endocytosis and retrograde trafficking in cancer cells regulate ICAM1 organization at the immune synapse and influence cytotoxic CD8 T cell response.