Browse our Research Articles

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    1. Plant Biology

    Life-cycle-related gene expression patterns in the brown algae

    Pélagie Ratchinski, Olivier Godfroy ... J Mark Cock
    Life-cycle- and development-related patterns of gene expression are conserved in diverse brown algae.
    1. Biochemistry and Chemical Biology

    MCAK recognizes the nucleotide-dependent feature at growing microtubule ends

    Wei Chen, Yin-Long Song ... Xin Liang
    A key finding is that MCAK binds to the proximal region of GTP cap where GDP‧Pi-tubulins accumulate, in addition to curved protofilaments at the distalmost tip.
    1. Neuroscience

    Mother-child dyadic interactions shape the developing social brain and Theory of Mind in young children

    Lei Li, Jinming Xiao ... Xujun Duan
    Children’s social cognitive development emerges from the dynamic interplay of neural maturation, parental caregiving, and dyadic brain-to-brain synchrony.
    1. Cell Biology
    2. Computational and Systems Biology

    Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth

    Dengjin Li, Hai Zheng ... Chenli Liu
    Chromosome-driven DnaA activity oscillations, modulated by DNA-binding proteins, enable bacteria to coordinate DNA replication with biomass growth independently of transcriptional regulation.
    1. Plant Biology

    Fifteenth century CE Bolivian maize reveals genetic affinities with ancient Peruvian maize

    Huan Chen, Amy Baetsen-Young ... Gabriel Wrobel
    Genomic evidence from 15th-century Bolivian maize reveals similarity to Central Andean maize from Peru, and pre-Inca and Inca-era breeding that enhanced maize development through selection within Andean agricultural networks.
    1. Genetics and Genomics

    Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish

    Laura Lopez-Blanch, Cristina Rodríguez-Marin ... Manuel Irimia
    A multi-level assessment of the relevance of 18 highly conserved neural zebrafish microexons showed that individual deletions of most microexons did not exhibit strong phenotypes, likely because of compensatory changes.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians

    Ryan A McCubbin, Mohammad A Auwal ... Ricardo M Zayas
    A conserved POU4-dependent developmental program underlies mechanosensory neuron regeneration in adult planarians.
    1. Neuroscience

    Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem

    Zahra Khodadadi, Daniel Trpevski ... Jeanette Hellgren Kotaleski
    Biophysically detailed modeling predicts that a biologically plausible synaptic plasticity rule, gated by calcium and dopamine, enables single neurons to solve nonlinear binding tasks by exploiting dendritic nonlinearities.
    1. Medicine

    The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming

    Zachary W Grimmett, Rongli Zhang ... Jonathan S Stamler
    Mice lacking the denitrosylase enzyme SCoR2 demonstrate robust cardioprotection resulting from coordinate reprogramming of multiple metabolic pathways.
    1. Cancer Biology

    Causal associations between human plasma proteins and prostate cancer identified by proteome-wide Mendelian randomization

    Lin Chen, Yanlun Gu ... Xiaocong Pang
    The identification of 20 causal plasma proteins for prostate cancer represents a critical step toward addressing the need for improved diagnostic specificity and reveals promising new targets for therapeutic intervention.