Browse our Research Articles

Page 3 of 1,485
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Lineage priming and cell type proportioning depends on the interplay between stochastic and deterministic factors

    William Salvidge, Chris Brimson ... Chris Thompson
    Experiments and mathematical modelling show cell fate in Dictyostelium discoideum partly depends on cell-cycle phase, but also on stochastic gene-expression variability which enhances robustness of developmental responses to cell-cycle perturbation.
    1. Chromosomes and Gene Expression

    Single-domain antibody inhibitors target the coiled coil arms of the Bacillus subtilis SMC complex

    Ophélie J Gosselin, Michael Taschner ... Stephan Gruber
    A screen using in vitro-selected synthetic nanobodies identified inhibitors of SMC protein function in bacterial cells, revealing a coiled coil region as a vital component of the chromosome-folding machinery.
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    1. Neuroscience

    Two neuropeptides that promote blood feeding in Anopheles stephensi mosquitoes

    Prashali Bansal, Roshni Pillai ... Sonia Q Sen
    Neuropeptides sNPF and RYamide promote blood feeding in Anopheles stephensi, a major malarial vector in the Indian subcontinent and West Africa.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Redirection of SARS-CoV-2 to phagocytes by intranasal sACE2-Fc as a universal decoy confers complete prophylactic protection

    Jingyi Wang, Jiangchuan Li ... Bo Feng
    Functional and mechanistic analyses reveal that intranasal decoys engage phagocytic clearance beyond viral neutralization to provide effective protection, establishing immune redirection for developing broad-spectrum countermeasures against airborne viral threats.
    1. Genetics and Genomics

    Mapping of in vivo cleavage sites uncovers a major role for yeast RNase III in regulating protein-coding genes

    Lee-Ann Notice-Sarpaning, Mathieu Catala ... Ambro van Hoof
    The yeast Drosha homolog Rnt1 has a major role in mRNA degradation.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Identification and classification of ion channels across the tree of life provide functional insights into understudied CALHM channels

    Rahil Taujale, Sung Jin Park ... Natarajan Kannan
    An evolution-guided framework is proposed to accelerate the discovery and therapeutic targeting of understudied dark channels by integrating sequence, structure, and functional data from diverse organisms.
    1. Ecology
    2. Evolutionary Biology

    Rapid riparian ecosystem recovery in low-latitudinal North China following the end-Permian mass extinction

    Wenwei Guo, Li Tian ... Jinnan Tong
    In low-latitude North China, riparian ecosystems began to recover 2–3 million years after the end-Permian mass extinction.
    1. Neuroscience

    Circadian control of a sex-specific behavior in Drosophila

    Sabrina Riva, Maria Fernanda Ceriani ... Diana Lorena Franco
    A semi-automated system for monitoring egg-laying reveals that lateral dorsal neurons are key regulators of circadian oviposition, showing that the neural circuits controlling oviposition and circadian locomotor behavior are different.
    1. Genetics and Genomics

    Stranded short nascent strand sequencing reveals the topology of DNA replication origins in Trypanosoma brucei

    Slavica Stanojcic, Bridlin Barckmann ... Yvon Sterkers
    Replication origins in Trypanosoma brucei integrate multiple features previously described individually in opisthokonts, revealing a unified structural topology built from strand-specific nucleotide composition, G‑quadruplex enrichment, and distinctive nucleosome patterns.
    1. Neuroscience

    Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing

    Katrina Bartas, Pieter Derdeyn ... Kevin T Beier
    Addictive drugs, as well as ketamine/xylazine, change the connectivity to ventral tegmental area dopamine cells, which may be related to cellular activity.