Different aspects of thermal stimuli, such as speed and intensity, are detected by distinct TRP channel-based mechanisms, with TRPV1 and TRPM2 playing unique roles in warmth perception and thermal decision-making.
A subset of hippocampal place cells, which is phase-locked to fast gamma rhythms, compressively encodes information at precessing slow gamma phases and therefore predominates to theta sequence development.
Tumor-suppressive protein FRMD8 inhibits breast cancer progression by regulating the level of ERα and has the possibility to be a potential target for overcoming tamoxifen treatment resistance.
Carley N Gray, Manickam Ashokkumar ... Michael Emerman
A block to more potent and specific release of HIV from latency has been identified as a subunit of the Integrator complex, which may aid strategies for HIV cure.
Slaven Crnkovic, Helene Thekkekara Puthenparampil ... Grazyna Kwapiszewska
Transition from healthy to diseased state is a cell-type-specific process, influenced by neighboring cells and resulting in functionally meaningful differences between pulmonary artery adventitial fibroblasts and smooth muscle cells.
Eric Weine, Samuel Pattillo Smith ... Arbel Harpak
The estimation of individual genetic effects across different contexts can be boiled down to a bias-variance trade-off, yet for complex traits, the joint consideration of numerous causal effects alters this trade-off.
