A key finding is that MCAK binds to the proximal region of GTP cap where GDP‧Pi-tubulins accumulate, in addition to curved protofilaments at the distalmost tip.
Children’s social cognitive development emerges from the dynamic interplay of neural maturation, parental caregiving, and dyadic brain-to-brain synchrony.
Chromosome-driven DnaA activity oscillations, modulated by DNA-binding proteins, enable bacteria to coordinate DNA replication with biomass growth independently of transcriptional regulation.
Genomic evidence from 15th-century Bolivian maize reveals similarity to Central Andean maize from Peru, and pre-Inca and Inca-era breeding that enhanced maize development through selection within Andean agricultural networks.
Laura Lopez-Blanch, Cristina Rodríguez-Marin ... Manuel Irimia
A multi-level assessment of the relevance of 18 highly conserved neural zebrafish microexons showed that individual deletions of most microexons did not exhibit strong phenotypes, likely because of compensatory changes.
Zahra Khodadadi, Daniel Trpevski ... Jeanette Hellgren Kotaleski
Biophysically detailed modeling predicts that a biologically plausible synaptic plasticity rule, gated by calcium and dopamine, enables single neurons to solve nonlinear binding tasks by exploiting dendritic nonlinearities.
The identification of 20 causal plasma proteins for prostate cancer represents a critical step toward addressing the need for improved diagnostic specificity and reveals promising new targets for therapeutic intervention.