Browse our Research Articles

Page 3 of 1,477
    1. Cell Biology
    2. Medicine

    Uncovering shared and tissue-specific molecular adaptations to intermittent fasting in liver, brain, and muscle

    Yibo Fan, Senuri De Silva ... Thiruma V Arumugam
    A multi-tissue proteomic atlas uncovers the shared and distinct molecular signatures of metabolic flexibility induced by intermittent fasting.
    1. Computational and Systems Biology

    Single-mRNA imaging and modeling reveal coupled translation initiation and elongation rates

    Irene Lamberti, Jeffrey A Chao ... Felix Naef
    Mammalian cells dynamically scale translation initiation to match distinct elongation rates, preventing ribosome crowding and preserving protein synthesis homeostasis across diverse transcripts.
    1. Ecology

    Geomagnetic and visual cues guide seasonal migratory orientation in the nocturnal fall armyworm, the world’s most invasive insect

    Yi-Bo Ma, Guijun Wan ... Gao Hu
    Behavioral evidence demonstrates that geomagnetic and visual cues are integrated to guide nocturnal migratory insects.
    1. Microbiology and Infectious Disease

    Global transcription factors analyses reveal hierarchy and synergism of regulatory networks and master virulence regulators in Pseudomonas aeruginosa

    Jiadai Huang, Yue Sun ... Xin Deng
    Systematic ChIP-seq profiling of 172 transcription factors in Pseudomonas aeruginosa reveals a hierarchical regulatory architecture governing virulence and establishes a searchable database to guide antimicrobial drug discovery.
    1. Immunology and Inflammation

    Heat shock factor regulation of antimicrobial peptides expression suggests a conserved defense mechanism induced by febrile temperature in arthropods

    Bang Xiao, Shihan Chen ... Chaozheng Li
    Febrile temperatures enhance antiviral immunity through heat shock factor-dependent antimicrobial peptides across arthropods.
    1. Developmental Biology

    Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitors

    Fengzhu Xiong, Andrea R Tentner ... Sean G Tsung-Megason
    Comparing signaling response profiles and fate outcomes in single cells reveals logic and limits of signal interpretation.
    1. Neuroscience

    Endogenous precision of the number sense

    Arthur Prat-Carrabin, Michael Woodford
    A theory of efficient coding wherein the precision of representations is endogenous, task-dependent, and prior-dependent predicts scaling laws for imprecision and is supported by numerosity perception experiments with humans.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Epigenetics and chromatin structure regulate var2csa expression and the placental-binding phenotype in Plasmodium falciparum

    Todd Lenz, Madle Sirel ... Ulf Ribacke
    Placenta-binding parasites show that chromatin-based mechanisms regulate placental malaria virulence gene, var2csa, and requires loss of H3K9me3-mediated heterochromatic silencing and 3D nuclear repositioning away from telomeric-repressive clusters.
    1. Chromosomes and Gene Expression

    TAD boundaries and gene activity are uncoupled

    Faisal Almansour, Nadezda A Fursova ... Tom Misteli
    Single-cell analysis fails to find a functional link between the organization of chromatin domain organization and gene activity.
    1. Neuroscience

    A stress-activated neuronal ensemble in the supramammillary nucleus produces anxiety-like behavior in male mice

    Jinming Zhang, Kexin Yu ... Jing Han
    Stress-recruited neurons can cause anxiety-like avoidance and increase peripheral corticosterone concentration.