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Quantitative Drosophila pupal wing experiments support planar polarity depending on cell-scale signalling that does not involve depletion of a limited pool of core proteins or polarised transport on microtubules.

Loss of function of Ptbp1 in retinal progenitors leads to changes in RNA splicing but does not affect neurogenesis and cell fate specification.

Cryo-EM and electrophysiology reveal the mechanism of SK2 channel modulation by the bee toxin apamin and small molecules, providing insights that enable the rational design of targeted SK2 channel therapeutics.

Songbird HVC sequences arise from a balance of ionic currents and structured inhibition, providing a mechanistic framework for understanding cortical sequence generation.

Hydration modulates aromatic interactions, explaining why Tyr is a stronger sticker than Phe in aqueous environments like protein condensates but not in the cores of folded proteins.

Sub-surface imaging demonstrates that vertical shear beneath fingertip ridges enables high mechanical spatial resolution to support tactile sensing.

Reducing vaccine development time from 12 months to 6 reduces forecasting error by 25%, while reducing lags in genome sequence submission reduces uncertainty of current clade frequencies by 50%.

Amino acids that were abundant since the prebiotic era are enriched in protein binding sites of the most ancient coenzymes, supporting the plausibility of an early coenzyme–peptide world.

A light–tone sensory preconditioning task in male mice is developed revealing sex differences and demonstrating that dorsal, but not ventral, hippocampal CaMKII-positive neurons encode innocuous stimulus associations.

The Major Histocompatibility Complex region evolves via gene birth-and-death, resulting in short-lived genes, rapidly expanding gene subfamilies, and many gene fragments.