Heterogeneity in outcomes of differently located activating mutations of Notch indicates the need and potential for mutant specific targeting of Notch in cancer.
Leiomodin 1 acts as a critical molecular switch during early muscle stem cell differentiation by sequestering the deacetylase SIRT1 in the cytoplasm to initiate the myogenic program.
In-situ glial cell-surface proteomics reveals DIP-β as a glial longevity factor that enhances intercellular communication and extends lifespan in aging Drosophila.
Gene dosage imbalance due to the triplication of human chromosome 21 gene orthologs impairs whole-body glucose and lipid metabolism by disrupting homeostatic processes across major metabolic tissues.
Rachel H Clare, Adam Westhorpe ... Nicholas R Casewell
Despite the variation in venom across the Bothrops snake genus, repurposed drugs demonstrated pan-species neutralisation in enzymatic, coagulation, and haemorrhage assays, highlighting their value as novel therapies for Neotropical snakebites.
Fangfang Hong, Ruby Bouhassira ... David H Brainard
Leveraging the smooth variation of internal noise makes comprehensive characterization of color discrimination practical, offering an efficient framework for studying perceptual limits across various sensory domains.
Hidden outward-facing intermediates and long-lived ATP-bound states reveal how ATP binding drives conformational dynamics in the heterodimeric ABC transporter TmrAB.
Hanane Hadj-Moussa, Megan Ulusan ... Jonathan Houseley
Re-engineering a highly conserved metabolic pathway in yeast prevents age-related functional decline and proves that ageing is not inevitably linked to loss of fitness.
Inflammatory activation of endothelial cells triggers Pink1-dependent mitophagy and mitochondrial formyl peptides release, which drives neutrophil recruitment and lung injury.
