Mammalian cells dynamically scale translation initiation to match distinct elongation rates, preventing ribosome crowding and preserving protein synthesis homeostasis across diverse transcripts.
Systematic ChIP-seq profiling of 172 transcription factors in Pseudomonas aeruginosa reveals a hierarchical regulatory architecture governing virulence and establishes a searchable database to guide antimicrobial drug discovery.
A theory of efficient coding wherein the precision of representations is endogenous, task-dependent, and prior-dependent predicts scaling laws for imprecision and is supported by numerosity perception experiments with humans.
Placenta-binding parasites show that chromatin-based mechanisms regulate placental malaria virulence gene, var2csa, and requires loss of H3K9me3-mediated heterochromatic silencing and 3D nuclear repositioning away from telomeric-repressive clusters.