Browse our Research Articles

Page 3 of 1,470
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Superoxide dismutases maintain niche homeostasis in stem cell populations

    Olivia Majhi, Aishwarya Chhatre ... Devanjan Sinha
    Superoxide dismutases, particularly Sod1, differentially tune redox signaling of germline and cyst stem cells, enabling their self-renewal and differentiation, thereby maintaining Drosophila testicular stem cell homeostasis.
    1. Neuroscience

    Dynamic regulation of mRNA acetylation at synapses by spatial memory in mouse hippocampus

    Hai-Qian Zhou, Zhen Zhu ... Dong-Min Yin
    NAT10-mediated mRNA acetylation links neural activity to local protein synthesis at synapses, influencing memory consolidation.
    1. Microbiology and Infectious Disease

    4-Aminoquinolines block heme iron reactivity and interfere with artemisinin action

    Melissa Rosenthal, Daniel E Goldberg
    Chloroquine interferes with artemisinin activation, and such interactions should be considered when formulating antimalarial drug combinations.
    1. Cancer Biology

    Blocking SHP2 benefits FGFR2 inhibitor and overcomes its resistance in FGFR2-amplified gastric cancer

    Yue Zhang, Hanbing Wang ... Yue Wang
    Dual blocking SHP2 and FGFR2 can not only promote the targeted tumor-killing effects and overcome FGFR2 inhibitor resistance caused by feedback activation, but also activate T cell-mediated anti-tumor immunity.
    1. Immunology and Inflammation

    Ex vivo and in vivo CRISPR/Cas9 screenings identify the roles of protein N-glycosylation in regulating T-cell activation and functions

    Yu Hong, Xiaofang Si ... Yu Zhang
    Inactivation of beta 1,4-galactosyltransferase 1 leads to enhanced T-cell receptor activation and CD8+ T-cell function by affecting the galactosylation of T-cell receptor and CD8.
    1. Developmental Biology
    2. Evolutionary Biology

    Developmental, regenerative, and behavioral dynamics in acoel reproduction

    Vikram Chandra, Samantha Elizabeth Tseng ... Mansi Srivastava
    Studying the reproductive life history of an acoel reveals that a body-size-dependent program regulates organ growth and regeneration dynamics and discovers a novel form of egg-laying behavior.
    1. Genetics and Genomics

    Competition for the conserved branch point sequence influences physiological outcomes in pre-mRNA splicing

    Karen Larisssa Pereira de Castro, Jose M Abril ... William S Fagg
    Competition between Quaking and SF1 for a subset of ACUAA intron branch sites influences alternative splicing in different tissues and organisms.
    1. Cell Biology

    Specific GPCRs elicit unique extracellular vesicle miRNA array signatures

    Xiao Shi, Michelle C Palumbo ... Aaron J Janowsky
    Unique extracellular vesicle microRNA signatures resulting from G protein-coupled receptor activation indicate distinct downstream signaling and functional networks by receptor, with implications for developing new drugs and understanding their long-term and off-target effects.
    1. Neuroscience

    Functional connectivity-based attractor dynamics of the human brain in rest, task, and disease

    Robert Englert, Balint Kincses ... Tamas Spisak
    Functional connectivity reveals brain attractors that match predictions of free‑energy‑minimizing attractor theory, yielding an interpretable generative model of brain dynamics in rest, task, and disease.
    1. Microbiology and Infectious Disease

    Mycobacterial metallophosphatase MmpE acts as a nucleomodulin to regulate host gene expression and promote intracellular survival

    Liu Chen, Baojie Duan ... Aizhen Guo
    Mycobacterium tuberculosis utilizes nucleomodulins to disrupt host inflammatory responses and lysosomal maturation, uncovering a novel strategy for immune evasion and intracellular survival.