Browse our Research Articles

Page 5 of 1,471
    1. Neuroscience

    Formation of task representations and replay in mouse medial prefrontal cortex

    Hamed Shabani, Hannah Muysers ... Christian Leibold
    Longitudinal calcium imaging in the medial prefrontal cortex reveals the emergence of de novo task representations and reward-associated replay.
    1. Neuroscience

    iGABASnFR2 is an improved genetically encoded protein sensor of GABA

    Ilya Kolb, Jeremy P Hasseman ... Glenn C Turner
    An improved genetically encoded GABA sensor enables the most effective direct optical measurement of inhibitory neurotransmission to date.
    1. Neuroscience

    Functional connectivity-based attractor dynamics of the human brain in rest, task, and disease

    Robert Englert, Balint Kincses ... Tamas Spisak
    Functional connectivity reveals brain attractors that match predictions of free‑energy‑minimizing attractor theory, yielding an interpretable generative model of brain dynamics in rest, task, and disease.
    1. Neuroscience

    Visual experience shapes functional connectivity between occipital and non-visual networks

    Mengyu Tian, Xiang Xiao ... Marina Bedny
    At birth, infant visual cortex connectivity resembles that of blind adults, while lifetime visual experience enhances long-range functional connectivity between visual cortices, sensorimotor systems, and dampens connectivity with executive networks.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration in human cancer cells

    Ravi Kumar, Simon Couly ... Ashish Lal
    Global proteomics and functional analyses reveal that p53-induced ZMAT3 suppresses mitochondrial respiration by inhibiting transcription of a hexokinase, uncovering a role for ZMAT3 in transcription.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice

    Philip MM Ruppert, Aylin S Gueller ... Jan-Wilhelm Kornfeld
    Transcriptomic profiling on liver and adipose depots reveals tissue-specific and beige-fat–convergent responses to methionine restriction and cold, providing a high-quality resource to guide combinatorial lifestyle interventions for metabolic disease research.
    1. Developmental Biology
    2. Neuroscience

    The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

    Sen-Lin Lai, Chris Q Doe
    Fd4 is expressed in NB7-1 and new-born progeny where it activates terminal selector genes to produce lineage-specific neurons.
    1. Neuroscience

    Distinct representational properties of cues and contexts shape fear and reversal learning

    Antoine Bouyeure, Daniel Pacheco-Estefan ... Nikolai Axmacher
    Fear updating relies on a flexible shift from generalized to item-specific, context-bound neural representations, revealing how the brain adapts to changing threat contingencies and why fear can return.
    1. Genetics and Genomics

    The impact of stability considerations on genetic fine-mapping

    Alan J Aw, Lionel Chentian Jin ... Yun S Song
    In statistical fine-mapping, signals stable across stratified subgroups can capture functionally important loci missed by covariate adjustment approaches, and prioritizing agreement between both approaches enhances functional variant discovery.
    1. Neuroscience

    Sex-specific single transcript level atlas of vasopressin and its receptor (AVPR1a) in the mouse brain

    Anisa Azatovna Gumerova, Georgii Pevnev ... Vitaly Ryu
    Using RNAscope mapping provides the comprehensive, sex-specific atlas of vasopressin and its receptor gene expression across the murine brain, refining understanding of how vasopressin signaling is anatomically organized to regulate social behavior, stress responsivity, and homeostasis.