Multiomics and biochemical studies reveal that excess ATP levels, and not ROS, is the dominant driver for antibiotic cidality in Mycobacterium smegmatis.
Magdalena Boch, Katrin Karadachka ... Rogier B Mars
A large-scale investigation of carnivoran brain diversity, providing a unified description of folding patterns, their relationship to behaviour and ecology, and the foundation for future investigations of carnivoran neuroecology.
Linking biological research with disordered-systems modeling, providing new insights into gut microbiome stability, functioning, and their relationship with health.
Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based epigenome editing.
Giulia Di Bartolomei, Raúl Ortiz ... Peter Scheiffele
An alternative splicing regulator previously implicated in calcium signaling in the heart ensures cell-type-specific mRNA processing of long neuronal mRNAs in the mouse brain.
Mathias Sablé-Meyer, Lucas Benjamin ... Stanislas Dehaene
fMRI and MEG results in adults and children show encoding of abstract geometric regularities in dorsal-parietal, temporal, and frontal regions, pointing to a system for symbolic geometric representation in humans.
J Ignacio Gutierrez, Claudia Edgar, Jessica K Tyler
Live imaging analyses in budding yeast reveal that calorie restriction and overexpression of the mRNA binding protein Ssd1 both block deleterious age-dependent iron uptake as a mechanism to extend lifespan.
Lipid imbalance triggered by Snail-driven epithelial–mesenchymal transition creates a cholesterol-dependent vulnerability that can be therapeutically targeted to overcome chemoresistance in cancer.
