Browse our Research Articles

Page 5 of 1,455
    1. Physics of Living Systems

    Linking complex microbial interactions and dysbiosis through a disordered Lotka–Volterra model

    Jacopo Pasqualini, Amos Maritan ... Samir Suweis
    Linking biological research with disordered-systems modeling, providing new insights into gut microbiome stability, functioning, and their relationship with health.
    1. Cell Biology
    2. Neuroscience

    Dilated cardiomyopathy-associated RNA-binding motif protein 20 regulates long pre-mRNAs in neurons

    Giulia Di Bartolomei, Raúl Ortiz ... Peter Scheiffele
    An alternative splicing regulator previously implicated in calcium signaling in the heart ensures cell-type-specific mRNA processing of long neuronal mRNAs in the mouse brain.
    1. Cell Biology

    Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance

    Atsushi Matsumoto, Akihito Inoko ... Junichi Ikenouchi
    Lipid imbalance triggered by Snail-driven epithelial–mesenchymal transition creates a cholesterol-dependent vulnerability that can be therapeutically targeted to overcome chemoresistance in cancer.
    1. Neuroscience

    Two classes of amine/glutamate multi-transmitter neurons innervate Drosophila internal male reproductive organs

    Marta Chaverra, John Paul Toney ... R Steven Stowers
    Drosophila internal male reproductive organs exhibit parallel innervation by two types of multi-transmitter neurons, a subset of which are essential for fertility, and organ-specific spatially discrete neurotransmitter receptor expression.
    1. Biochemistry and Chemical Biology

    The interplay between biomolecular assembly and phase separation

    Giacomo Bartolucci, Ivar S Haugerud ... Christoph A Weber
    Biomolecular assembly typically promotes phase separation while the presence of coexisting phases alters assembly kinetics.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during BV2 microglial activation

    Benoit Arnould, Adeline Martz ... Thomas Grutter
    An affinity-guided chemical strategy enabling highly specific biotinylation of P2X7 receptors reveals, by super-resolution microscopy, how the nanoscale organization of endogenous P2X7 in BV2 microglial cells dynamically changes upon activation.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Short activation domains control chromatin association of transcription factors

    Vinson B Fan, Abrar A Abidi ... Max V Staller
    Single-molecule tracking of transcription factors in living cells revealed how mutations that make short activation domains stronger increased the fraction of transcription factor molecules bound to chromatin and led to longer residence times on chromatin.
    1. Neuroscience

    Dissecting surveying behavior of reactive microglia under chronic neurodegeneration

    Sunitha Subhramanian, Olga Bocharova ... Ilia V Baskakov
    In chronic neurodegeneration associated with prion disease, reactive microglia adopt a highly mobile, neuron-by-neuron surveillance strategy, replacing homeostatic process-based monitoring with dynamic somatic migration and prolonged neuronal engagement.
    1. Computational and Systems Biology
    2. Neuroscience

    Reconstructing voice identity from noninvasive auditory cortex recordings

    Charly Lamothe, Etienne Thoret ... Pascal Belin
    A low-dimensional voice latent space derived from deep learning captures speaker-identity representations in the temporal voice areas and supports reconstruction of voices preserving identity information.
    1. Neuroscience

    Pupil dilation offers a time-window on prediction error

    Olympia Colizoli, Tessa M van Leeuwen ... Harold Bekkering
    Pupil dilation provides a physiological readout of information gain during the brain's internal process of belief updating in the context of associative learning.