Browse our Research Articles

Page 5 of 1,455
    1. Neuroscience

    A geometric shape regularity effect in the human brain

    Mathias Sablé-Meyer, Lucas Benjamin ... Stanislas Dehaene
    fMRI and MEG results in adults and children show encoding of abstract geometric regularities in dorsal-parietal, temporal, and frontal regions, pointing to a system for symbolic geometric representation in humans.
    1. Cell Biology

    Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake

    J Ignacio Gutierrez, Claudia Edgar, Jessica K Tyler
    Live imaging analyses in budding yeast reveal that calorie restriction and overexpression of the mRNA binding protein Ssd1 both block deleterious age-dependent iron uptake as a mechanism to extend lifespan.
    1. Physics of Living Systems

    Linking complex microbial interactions and dysbiosis through a disordered Lotka–Volterra model

    Jacopo Pasqualini, Amos Maritan ... Samir Suweis
    Linking biological research with disordered-systems modeling, providing new insights into gut microbiome stability, functioning, and their relationship with health.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Short activation domains control chromatin association of transcription factors

    Vinson B Fan, Abrar A Abidi ... Max V Staller
    Single-molecule tracking of transcription factors in living cells revealed how mutations that make short activation domains stronger increased the fraction of transcription factor molecules bound to chromatin and led to longer residence times on chromatin.
    1. Biochemistry and Chemical Biology

    The interplay between biomolecular assembly and phase separation

    Giacomo Bartolucci, Ivar S Haugerud ... Christoph A Weber
    Biomolecular assembly typically promotes phase separation while the presence of coexisting phases alters assembly kinetics.
    1. Neuroscience

    Two classes of amine/glutamate multi-transmitter neurons innervate Drosophila internal male reproductive organs

    Marta Chaverra, John Paul Toney ... R Steven Stowers
    Drosophila internal male reproductive organs exhibit parallel innervation by two types of multi-transmitter neurons, a subset of which are essential for fertility, and organ-specific spatially discrete neurotransmitter receptor expression.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during BV2 microglial activation

    Benoit Arnould, Adeline Martz ... Thomas Grutter
    An affinity-guided chemical strategy enabling highly specific biotinylation of P2X7 receptors reveals, by super-resolution microscopy, how the nanoscale organization of endogenous P2X7 in BV2 microglial cells dynamically changes upon activation.
    1. Neuroscience

    Dissecting surveying behavior of reactive microglia under chronic neurodegeneration

    Sunitha Subhramanian, Olga Bocharova ... Ilia V Baskakov
    In chronic neurodegeneration associated with prion disease, reactive microglia adopt a highly mobile, neuron-by-neuron surveillance strategy, replacing homeostatic process-based monitoring with dynamic somatic migration and prolonged neuronal engagement.
    1. Computational and Systems Biology
    2. Neuroscience

    Reconstructing voice identity from noninvasive auditory cortex recordings

    Charly Lamothe, Etienne Thoret ... Pascal Belin
    A low-dimensional voice latent space derived from deep learning captures speaker-identity representations in the temporal voice areas and supports reconstruction of voices preserving identity information.
    1. Cell Biology
    2. Genetics and Genomics

    Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in Caenorhabditis elegans, challenges a proposed role in heme trafficking

    Sarah E Sandkuhler, Kayla S Youngs ... Samuel J Mackenzie
    Evidence from multiple model systems supports a shift away from heme transport and toward metabolic dysfunction and oxidative stress as key drivers of TANGO2 deficiency.