Y-complex nucleoporin, Nup107, can regulate ecdysone production by affecting the transcription of Halloween genes and levels of RTK receptor, torso, for the metamorphic transition from larva to pupa.
Stress activates a locus coeruleus–spinal dorsal horn noradrenergic circuit that drives mechanical pain hypersensitivity through Hes5-positive astrocytes.
Zachary L Reitz, Bita Pourmohsenin ... Marnix H Medema
Automated detection of metallophore biosynthesis reveals that metal-chelating non-ribosomal peptides are widespread, chemically diverse, and deeply rooted in bacterial evolution.
Merry Faye E Graff, Emma EM Heeg ... Sarah J Childs
Loss of foxf2 in zebrafish leads to a reduced pericyte progenitor pool in embryos and progresses to severe cerebrovascular defects over the lifespan, suggesting that cerebral small vessel disease in adults has roots in development.
A conserved glucagon signaling pathway links high-fat diet-induced metabolic imbalance to cardiac arrhythmia through hormone-producing cells and heart-innervating neurons that regulate rhythmicity.
Concurrent decoding of acoustic detail and linguistic structure enables natural, intelligible speech synthesis from limited human cortical recordings, resolving a fundamental constraint in neural speech reconstruction.
The adjoint propagation framework enables the concurrent flow of signals and errors, providing a biologically and physically plausible learning mechanism.
Yatendra Kumar, Dipta Sengupta ... Wendy A Bickmore
Acetylation of histone H3 at the nucleosome surface is associated with destabilised nucleosomes and is a useful new functional genomics mark for identifying regulatory regions of the mammalian genome.
DNA damage reshapes genome-wide transcriptional bursting, with distinct burst size and frequency programs associated with differentiation, apoptosis, and survival decisions.
