Merle Marie Schuckart, Sandra Martin ... Jonas Obleser
Analyses of self-paced reading times reveal that linguistic prediction deteriorates under limited executive resources, with this resource sensitivity becoming markedly more pronounced with advancing age.
Intrinsic conformational flexibility of a solute transporter is restrained by substrates, resulting in Na+ allosterically enhancing primary substrate binding through cooperative constraints on the dynamics of the cytoplasmic inner barrier.
A novel F-actin-binding motif consisting of an α-helix hairpin from a Legionella pneumophila lysine fatty acyltransferase has the potential to be developed as an F-actin probe.
Marie-Cécile Dupas, Maria F Vincenti-Gonzalez ... Simon Dellicour
Post-2020, highly pathogenic avian influenza H5 circulation is characterised by spatially expanded ecological suitability, changes in key environmental predictors, and a wider range of avian species affected.
Abdulkadir Ozkan, Hari K Padmanabhan ... Jeffrey D Macklis
Developmentally-based directed differentiation from cortical progenitors sets a foundation for in vitro mechanistic and therapeutic disease modeling, and toward regenerative neuronal repopulation and circuit repair.
Durafshan Sakeena Syed, Primoz Ravbar, Julie H Simpson
Anatomical and behavioral characterization of inhibitory neurons in the Drosophila ventral nerve cord shows their critical, diverse roles in limb coordination.
Developmental electrophysiological adaptations and heat-sensitive proteins, such as TRPV3, in cortical excitatory neurons help maintain stable activity levels when brain temperature rises by 2–3°C during fever.
Bidirectional modulation of the activity of the synaptic protein mGluR5 alters spontaneous mouse motor behavior and produces correlated changes in co-activity patterns among direct pathway neurons in the dorsal striatum.
A microglia replacement approach demonstrates that brain macrophages with patient mutations from Aicardi–Goutières syndrome, a genetic, brain predominant interferonopathy, are sufficient to drive interferon responses.
Upregulation of the β subunit of translation initiation factor eIF2 underlies autophagy suppression and premature aging caused by disruption of axonal transport of mitochondria.
