Systematic ChIP-seq profiling of 172 transcription factors in Pseudomonas aeruginosa reveals a hierarchical regulatory architecture governing virulence and establishes a searchable database to guide antimicrobial drug discovery.
A theory of efficient coding wherein the precision of representations is endogenous, task-dependent, and prior-dependent predicts scaling laws for imprecision and is supported by numerosity perception experiments with humans.
Placenta-binding parasites show that chromatin-based mechanisms regulate placental malaria virulence gene, var2csa, and requires loss of H3K9me3-mediated heterochromatic silencing and 3D nuclear repositioning away from telomeric-repressive clusters.
Structural and biochemical analyses identify a bacterial lipoprotein that associates with the outer membrane component of tripartite multi-drug efflux pumps, and its potential functional roles are explored by complementary bioinformatics, proteomcid and genetic approaches.
Synaptotagmin 1 and Synaptotagmin 7 promote MAIT cell activation during Mycobacterium tuberculosis infection by facilitating MR1 trafficking and antigen presentation.
Geometric confinement paradoxically enhances bacterial chemotaxis through chiral surface swimming and sidewall alignment, with optimal performance when lane width matches the circular swimming radius.
