David Papadopoli, Ranveer Palia ... Ivan Topisirovic
Downregulation of the electron transfer flavoprotein dehydrogenase drives pro-tumorigenic metabolic programs via stimulating the mechanistic Target of Rapamycin Complex 1 signaling across a broad spectrum of cancers.
RadD recognition by NKp46 converts Fusobacterium nucleatum from an immune-evasive pathogen into a trigger of natural killer cell-mediated tumor control in a context-dependent manner.
Residual plasma from rapid routine clinical chemistry tubes enables cell-free DNA NGS-based analysis, providing an untapped, scalable, and accessible resource without specialized collection workflows.
An on-demand seizure model in chronically epileptic mice integrates reliability and etiological relevance, providing a mechanistically grounded, efficient platform for evaluating pharmacological interventions.
During convergent extension morphogenesis, non-canonical Wnt induces the signal transducer Dishevelled to transition from Vangl to Frizzled, a process that is inhibited by Prickle but facilitated by the co-receptor Ror.
Chengcheng Fan, Alexander A Cohen ... Magnus AG Hoffmann
Bivalent EABR mRNA boosters broaden neutralizing responses to Omicron subvariants by promoting diverse receptor-binding domain epitope targeting, although antibody responses remain partially shaped by immune imprinting from prior vaccination.
The thermosensory neuron AFD unexpectedly modulates locomotion based on tactile experience through molecular and circuit mechanisms distinct from those underlying thermosensation.
Genetic experiments combined with cellular and biochemical analyses including lipidomics performed by imaging mass spectrometry reveal that the capacity of mature B lymphocytes and germinal center B cells to synthesize some ether phospholipids is vital for normal humoral responses.
