Direct presynaptic patch-clamp recording and fluorescent imaging of the vesicular release demonstrate that a non-canonical cannabinoid receptor GPR55 deprives readily releasable vesicles of competency in cerebellar Purkinje cell axons.
Genomic neighborhood signatures delineate catalytic versus putative regulatory CODH clades, establishing a framework for predicting enzyme functionality and guiding discovery of biocatalysts for CO2 reduction.
Dysregulated exocytosis of bis(monoacylglycerol)phosphate (BMP)-enriched extracellular vesicles driven by pathogenic LRRK2 activity supports elevated urinary BMP levels and its use as a biomarker for Parkinson's disease.
Peptidoglycan recycling is essential for proper cell growth and intrinsic ampicillin resistance in Caulobacter crescentus, highlighting PG recycling enzymes as potential antibacterial targets.
A hierarchical framework integrating artificial intelligence with chemical principles enables the conversion of fragile α-helices into ultrastable protein scaffolds.
Psilocin induces a durable neuroplastic state in human cortical neurons by enhancing BDNF signaling, neurite complexity, synaptogenesis, and synaptic network activity through 5-HT2A receptor-dependent mechanisms.
