Cyp17a2 enhances antiviral responses in male zebrafish by stabilizing STING through TRIM11-mediated K33-linked polyubiquitination, boosting IFN production.
Eric R Wengert, Sophie R Liebergall ... Ethan M Goldberg
Brain slice electrophysiology, immunohistochemistry, and in vivo two-photon calcium imaging identify circuit dysfunction and epilepsy mechanism in a Kcnc1-A421V/+ mouse model of developmental and epileptic encephalopathy.
Volume EM and connectome reconstruction of the apical organ of a ctenophore combined with high-speed imaging reveals a neuronal coordination of balancer cilia in the gravisensory organ.
Severine LD Toussaint, Dionisios Youlatos, John A Nyakatura
Vertical locomotion in arboreal mammals is shaped by a complex interplay of body mass, limb proportions, grasping abilities, and head mass, and primates use distinct upright postures during descents.
Adam A Atanas, Alicia Kun-Yang Lu ... Steven W Flavell
New machine vision tools are used to align densely packed cells recorded from live, deforming tissues and automatically annotate the identities of the recorded cell types.
A detailed annotation of anatomical brain structures (some novel) of the spider Uloborus diversus is provided based on a three-dimensional immunostain atlas.
Jean-Mathieu Desveaux, Eric Faudry ... Pascal Poignard
Human antibodies isolated from cystic fibrosis patients against PscF and PcrV of the Pseudomonas aeruginosa Type 3 Secretion System reveal that anti-PcrV antibodies inhibit secretion through distinct mechanisms.
Microfossils reported from Archaean BIFs most likely were liposome-like protocells, which had evolved intracellular mechanisms for energy conservation but not for regulating cell morphology and replication.
A threefold hippocampal code across conceptual directions, phase-locked to entorhinal grid activity, reveals a periodic mechanism through which entorhinal grids structure hippocampal vector representations.
