Browse our Research Articles

Page 5 of 1,521
    1. Genetics and Genomics
    2. Physiology

    NK2R signaling governs intestinal lipid mobilization and mucosal inflammation

    Pedro A Perez, Chung-Chih Liu ... Supriya Srinivasan
    NK2R is a molecular switch linking tachykinin signaling to intestinal lipid handling, mucosal inflammation and gut microbiota, positioning NK2R-targeted peptide therapeutics for cardiometabolic and inflammatory bowel diseases.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

    Wang Xu, Narendra Kumar Gonepudi ... Maolin Lu
    Antibodies can target multiple conformational states of the HIV envelope to block viral entry, broadening the mechanisms underlying neutralization.
    1. Microbiology and Infectious Disease

    The type VI secretion system governs strain maintenance in a wild mammalian gut microbiome

    Beth A Shen, Kyle L Asfahl ... Joseph D Mougous
    A type VI secretion system transferred between gut bacteria via a mobile genetic element stabilizes its native host strain, but yields only transient benefits in a new species.
    1. Neuroscience

    Mapping human visual contrast sensitivity and vision loss across the visual field with model-based fMRI

    Hugo T Chow-Wing-Bom, Matteo Lisi ... Tessa M Dekker
    Model‑based fMRI contrast‑sensitivity mapping provides a fixation‑tolerant, large‑field measure of cortical visual function that sensitively detects, localizes, and tracks visual field loss and recovery.
    1. Developmental Biology

    Genome-wide discovery of cis-regulatory elements in a large genome

    Gillian Forbes, Emilia Skafida ... Mathilde Paris
    Integrating genome-wide maps of chromatin accessibility and sequence conservation provides an accessible low-cost approach for identifying cis-regulatory elements in large genomes, validated in the emerging model Parhyale.
    1. Physiology

    Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage in Drosophila females

    Puja Biswas, Elizabeth J Rideout
    Sex-specific regulation of enteroendocrine hormones shapes energy storage differently in male and female flies.
    1. Developmental Biology

    Bidirectional redistribution of actomyosin drives epithelial invagination in ascidian siphon tube morphogenesis

    Jinghan Qiao, Pengyu Yu ... Bo Dong
    Bidirectional relocation of actomyosin as a novel mechanism drives invagination in developing organs.
    1. Neuroscience

    A cortical–hippocampal communication undergoes rebalancing after new learning

    Arron F Hall, Dong V Wang
    The anterior cingulate cortex selectively reorganizes communication with superficial CA1 neurons during sharp-wave ripples to balance memory consolidation following new learning.
    1. Neuroscience

    Negative affect influences the computations underlying food choice in bulimia nervosa

    Blair RK Shevlin, Loren Gianini ... Laura A Berner
    In bulimia nervosa, negative affect exaggerates a taste-before-health bias in food decision-making, and this bias is associated with more frequent out-of-control eating.
    1. Genetics and Genomics
    2. Neuroscience

    Learning is a fundamental source of individuality

    Riddha Manna, Johanni Brea ... Ana Marija Jakšić
    Beyond genotype × environment interactions, which can be shared and identical across individuals, learning from uniquely individual experiences further defines and diversifies individual behaviour.