The first all-atom models of the mycobacterial outer membrane reveal how lipid organization and asymmetry generate a structurally heterogeneous barrier that underlies its unique permeability properties.
Soenke Cordeiro, Robert Patejdl ... Marianne A Musinszki
Identification of mangostins as potent BK channel activators links natural xanthones to vascular smooth muscle relaxation, providing a mechanistic basis for their reported antihypertensive effects.
Sara M Frangos, Henver S Brunetta ... Graham P Holloway
Multi-omic and bioenergetic profiling in a HER2-driven mouse model of mammary cancer reveals that reduced mitochondrial content does not limit tumor respiratory capacity, which is instead dramatically elevated compared to benign mammary tissue.
Alicja Monaghan, Richard AI Bethlehem ... Duncan E Astle
Contrary to prior work, principal axes of structural and functional connectivity are established early in life, remaining stable and undergoing refinement throughout development.
Continuous flash suppression reduces V1 orientation responses in an ocular-dominance-dependent manner, which may still allow low-level coarse orientation discrimination but provide insufficient information for higher-level visual and cognitive tasks.
Theoretical and computational analyses demonstrate that cell intercalation within epithelial cell layers is analogous to the unbinding of topological defects in hexatic liquid crystals, offering a framework for calculating cellular forces and velocities during collective migration.
A conserved neuropeptidergic circuit directly links internal glucose levels to sweet taste sensitivity, providing a central mechanism for coupling metabolic state to feeding behavior.
Allocating space, materials and energy to an eye's optics and photoreceptor array is a major factor in eye design that explains obvious differences between simple eyes and compound eyes.
Friederike Steenken, Rainer Beutelmann ... Georg M Klump
In aging gerbils, compromised temporal fine structure perception is explained by a more prominent representation in auditory nerve fibers of temporal fluctuations of the signal envelope, rather than by synaptopathy.
