Browse our Research Articles

Page 5 of 1,370
    1. Neuroscience

    Active vision of bees in a simple pattern discrimination task

    HaDi MaBouDi, Jasmin Richter ... Lars Chittka
    Bumblebees refine visual discrimination through selective and structured scanning, demonstrating a dynamic interplay between movement and perception in pattern recognition.
    1. Genetics and Genomics

    Trade-offs in modeling context dependency in complex trait genetics

    Eric Weine, Samuel Pattillo Smith ... Arbel Harpak
    The estimation of individual genetic effects across different contexts can be boiled down to a bias-variance trade-off, yet for complex traits, the joint consideration of numerous causal effects alters this trade-off.
    1. Cell Biology
    2. Medicine

    Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

    Slaven Crnkovic, Helene Thekkekara Puthenparampil ... Grazyna Kwapiszewska
    Transition from healthy to diseased state is a cell-type-specific process, influenced by neighboring cells and resulting in functionally meaningful differences between pulmonary artery adventitial fibroblasts and smooth muscle cells.
    1. Cancer Biology

    STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer

    Huan Fang, Huichun Liang ... Ceshi Chen
    STAMPBL1 activates the transcription of GRHL3 by interacting with FOXO1 in nucleus, thereby upregulating the HIF1α/VEGFA axis and promoting angiogenesis in TNBC tumors, independently of its DUB activity.
    1. Cancer Biology
    2. Physics of Living Systems

    Mechanistic insight for T-cell exclusion by cancer-associated fibroblasts in human lung cancer

    Joseph Ackermann, Chiara Bernard ... Martine D Ben Amar
    The crosstalk between cancerous lesions and the immune system in the lungs demonstrates the complex role of fibroblasts.
    1. Medicine

    Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest

    Zhen Wang, Jie Zhu ... Xiang Zhou
    Exogenous mitochondrial transplantation improves cardiac function after cardiopulmonary resuscitation (CPR) may be related to improving mitochondrial function, reducing the oxidative stress response, and decreasing apoptosis in myocardial cells.
    1. Microbiology and Infectious Disease

    Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal

    Carley N Gray, Manickam Ashokkumar ... Michael Emerman
    A block to more potent and specific release of HIV from latency has been identified as a subunit of the Integrator complex, which may aid strategies for HIV cure.
    1. Neuroscience

    Repeated activation of preoptic area recipient neurons in posterior paraventricular nucleus mediates chronic heat-induced negative emotional valence and hyperarousal states

    Zhiping Cao, Wing-Ho Yung, Ya Ke
    A neural circuit mechanism explains how chronic extreme heat exposure affects emotions in the mouse model.
    1. Cancer Biology
    2. Cell Biology

    Cytosolic and endoplasmic reticulum chaperones inhibit wt-p53 to increase cancer cells' survival by refluxing ER-proteins to the cytosol

    Salam Dabsan, Gali Zur ... Aeid Igbaria
    Identifying the regulators of a non-genetic mechanism (ERCYS) that is constitutively activated in cancer cells to provide pro-survival properties.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery

    Conor J Howard, Nathan S Abell ... Nathan B Lubock
    Mapping the functional landscape of >6600 MC4R variants via deep mutational scanning reveals novel determinants of biased signaling and ligand interactions that inform targeted obesity therapeutics.