Funding mechanisms impact the cost effectiveness of the science conducted, as extramural NIH grants to universities excel at producing papers and citations, while intramural NIH hiring more effectively translates to clinical impact.
Absence of EML3 in mice leads to delayed embryonic development, small size, perinatal lethality, and the over-migration of neuroblasts due to a defective pial basement membrane.
Jason da Silva Castanheira, Christina Chang He ... Stephen M Fleming
Spatial attention controls the information people become aware of and, in turn, incorporate into simplified perceptual representations for use in multi-step planning.
Alphaherpesviruses hijack host epigenetic regulation by promoting HDAC1/2 nuclear export and degradation to activate the DNA damage response, revealing new antiviral therapeutic targets.
Michael B Heskett, Athanasios E Vouzas ... Mathew J Thayer
Stable allele-specific epigenetic regulation creates cellular mosaicism of numerous autosomal dosage-sensitive genes involved in human neurological and developmental disorders.
Peter Georgiev, Sheila Johnson ... Arlene H Sharpe
A comprehensive investigation of extracellular asparagine utilization highlights its role as a critical regulator of murine CD4+ T cell activation, differentiation, and function.
The yeast mitochondrial malate dehydrogenase–citrate synthase metabolon is a dynamic multienzyme complex that continuously assembles and disassembles in response to respiratory activity, mitochondrial matrix pH, and substrate abundances.
