Antoine Bouyeure, Daniel Pacheco-Estefan ... Nikolai Axmacher
Fear updating relies on a flexible shift from generalized to item-specific, context-bound neural representations, revealing how the brain adapts to changing threat contingencies and why fear can return.
In statistical fine-mapping, signals stable across stratified subgroups can capture functionally important loci missed by covariate adjustment approaches, and prioritizing agreement between both approaches enhances functional variant discovery.
Self-related information automatically modulates early attentional selection into awareness through mechanisms distinct from physical salience, revealing an obligatory, individualized self-prioritization at the gateway to perception.
Drew B Headley, Benjamin Latimer ... Satish S Nair
Beta and gamma inhibitory rhythms are preferentially tuned to govern synaptic integration in layer 5 pyramidal neurons by differentially modulating responses to inputs targeting distal dendritic and perisomatic compartments.
Compared with human-specific transcriptional factors, human-specific lncRNAs identified upon human lncRNAs’ orthologs in mammals have greatly evolved DNA-binding sites in archaic and modern humans in genes determining human traits.
Evidence is provided suggesting that aggregate neural activity at an early stage of visual processing (V1) can directly contribute to perceptual decisions in humans.
Prateek D Bansal, Maia Kinnebrew ... Diwakar Shukla
Multiple competing hypotheses concerning the cholesterol accessibility of oncoprotein Smoothened are quantitatively assessed and experimentally validated, showing that cholesterol takes two pathways from either membrane leaflet to the binding sites.
Mammalian oocytes utilize a conserved combination of cell cycle control, cytoskeletal organization, and polarity pathways that are fundamentally shared with other vertebrates and invertebrates.
Single-cell transcriptomics data from mouse bone-relevant cells was used to inform human bone mineral density genome-wide association studies and prioritize genetic targets with potential causal roles in the development of osteoporosis.
