Topographically distributed plCoA populations direct innate olfactory responses by signaling to divergent valence-specific targets, linking upstream olfactory identity to downstream valence behaviors, through a population code.
Dual blocking SHP2 and FGFR2 can not only promote the targeted tumor-killing effects and overcome FGFR2 inhibitor resistance caused by feedback activation, but also activate T cell-mediated anti-tumor immunity.
Majid Malboubi, Mohammad Hadi Esteki ... Guillaume Charras
Stable pressure gradients can arise in cells from the combination of actomyosin-generated cortical tension, cytoplasmic poroelasticity, and water flows across the membrane.
Unique extracellular vesicle microRNA signatures resulting from G protein-coupled receptor activation indicate distinct downstream signaling and functional networks by receptor, with implications for developing new drugs and understanding their long-term and off-target effects.
Vikram Chandra, Samantha Elizabeth Tseng ... Mansi Srivastava
Studying the reproductive life history of an acoel reveals that a body-size-dependent program regulates organ growth and regeneration dynamics and discovers a novel form of egg-laying behavior.
Inactivation of beta 1,4-galactosyltransferase 1 leads to enhanced T-cell receptor activation and CD8+ T-cell function by affecting the galactosylation of T-cell receptor and CD8.
