The Drosophila ryanodine receptor plays a conserved role in setting functional and structural muscle properties, regulates embryonic muscle development and could be used to assess the impact of human RYR1 mutations.
Intravital microscopy of meningeal macrophage Ca²⁺ dynamics reveals previously unknown population heterogeneity, vasomotion-coupled activity, and diverse responses during steady state and neuroinflammatory conditions, offering relevant insights into brain immune regulation.
Dissociable neural signatures of integration and segregation provide the first direct neuroimaging evidence for the integration-segregation theory of exogenous attention.
Marco Nigro, Lucas Silva Tortorelli ... Hongdian Yang
Inhibiting locus coeruleus input to the medial prefrontal cortex in mice impaired task performance, affected the tuning of single cortical neurons and disrupted population dynamics and encoding capacity during attentional switching.
Ryan T Maloney, Athena Q Ye ... Benjamin L de Bivort
Individual flies have idiosyncratic preferences that shift over their lifetime in a way that depends on genotype and may be adaptive to rapidly changing environmental pressures.
Adriana Quijada-Freire, César A Santiago ... Mario Mellado
HIV-1 remodels the spatial organization of its co-receptor, CXCR4, on T cell membranes, showing that viral entry requires receptor clustering rather than simple receptor binding.
In a stylized regime-shift detection task, human fMRI evidence shows that under- and overreactions to change arise from dissociable contributions of the frontoparietal network and ventromedial prefrontal cortex.
