Live cell imaging and biochemical analyses reveal that CCDC32 interacts with AP2 to stabilize and drive invagination of clathrin-coated pits, and that clinical mutations disrupting this interaction cause cardio-facio-neuro-developmental syndrome.
Acoustic ecology introduces an additional dimension in plant-insect communication, revealing that female moths use ultrasonic emissions from dehydrated plants to guide oviposition decisions.
During foraging under predatory threat, overlapping prefrontal neuron populations flexibly switch between encoding navigational space and predicting avoidance decisions.
Álvaro Escobar Doncel, Constantinos Patinios ... Colin J Ingham
Disrupting a single molybdenum cofactor gene allowed us to connect metabolic regulation of complex carbohydrates with cell organization, enabling genetic tuning of bacterial structural color for biomaterial applications.
Feedback signals to the early visual cortex convey both high-order and low-order visual information, but with different laminar profiles, and the high-order information is important for object recognition.
Constanza Salinas-Rebolledo, Javier Blesa ... Alejandro Rojas-Fernandez
Synthetic adaptors combining camelid nanobodies with the UBX domain of the p97 adaptor FAF1 enable targeted substrate delivery to p97, establishing an E3 ubiquitin ligase-independent mechanism for selective protein degradation.
Analysis of ~50 million articles published in ~50 thousand journals demonstrates that journals have become more diverse in terms of both interdisciplinarity and internationalization but with some disciplinary differences.
A conserved signaling axis linking Drosophila adipose tissue to nephrocyte function reveals how obesity can drive kidney dysfunction and points to new opportunities for therapeutic intervention.
