Hannu Lahtinen, Jaakko Kaprio ... Pekka Martikainen
Polygenic indices related to the best-established social, psychological, and behavioural mortality risk phenotypes had the strongest associations with mortality.
A comprehensive single-cell atlas of AML uncovers regulatory networks and age-dependent molecular differences to advance the understanding of disease mechanisms and enable subtype-specific therapeutic strategies.
Jennifer C Fielder, Jinyu Shi ... Nikolaus Steinbeis
A novel behavioural task that measures and manipulates subjective control in humans reveals that experimentally heightened feelings of control buffer against the negative impact of subsequent stress.
Excitatory recurrent synapses in the upper pyramidal layer of the prefrontal cortex exhibit delayed short-term facilitation, despite very high vesicular fusion probability, through synaptotagmin 7-dependent overfilling of release sites.
Muscle stem cells repurpose the tenogenic factor Scx to establish a muscle-specific transcriptional program that sustains stem cell expansion, migration, differentiation, fusion, self-renewal, and survival.
Drug repurposing analyses show that citalopram exerts anti-tumor effects by targeting C5aR1 on tumor-associated macrophages to enhance phagocytosis and CD8+ T cell immunity.