Maintaining CDK4/6 inhibition constrains drug‑resistant breast tumors by delaying cell‑cycle entry, and adding CDK2 inhibition further deepens control to guide post‑progression therapy.
Alina Xiaoyu Yang, Lisa Ramos-Rodriguez ... Yang Zhou
PLSCR1 is an IFN-λ-stimulated gene that enhances IFN-λR1 expression at both transcriptional and protein level, highlighting the potential for targeting PLSCR1 pathways in anti-influenza therapy.
Louis Richevaux, Dongkyun Lim ... Desdemona Fricker
Nonlinear dendritic integration in single presubicular neurons provides a mechanism for combining vestibular-based head-direction signals and visual landmark signals to anchor the brain’s internal compass.
Conan JO O'Brien, Giorgio Ratti ... Ana I Domingos
Loss of class A scavenger receptor MARCO results in elevated lung Ace expression and elevated plasma aldosterone concentrations in male mice, demonstrating an endocrine function of this immune scavenger receptor.
Oligodendrocytes with different morphological features work together to support precise binaural integration for sound localization in the chick brainstem auditory circuit.
Michael W Caldwell, Chase D Brownstein ... Tiago R Simões
Claims for a Triassic-aged crown lizard merit detailed reanalysis, the results of which find that Cryptovaranoides is not only not a lizard, but is a more distantly related diapsid reptile.
Stephen A Banse, Christine A Sedore ... Patrick C Phillips
Computer screening identifies that the widely prescribed vitamin A derivative all-trans retinoic acid increases both longevity and late-life health in a powerful genetic model system.
In spontaneous intracerebral hemorrhage patients, features of hematoma expansion can be visualized and predicted from non-contrast computed tomography using transport-based morphometry.