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Reversible cerebellar disruption in non-human primates reveals an acute muscle torque deficit and an adaptive slowing strategy to manage limb dynamics, underscoring distinct primary, and compensatory mechanisms underlying motor impairment.

The oligomerization domain of 53BP1, a key DNA repair protein, is a trimer which binds the dimeric hub protein LC8 by a novel mechanism to form dynamic heterogeneous complexes.

Polysome formation within the nucleoid and repulsion between these major cytoplasmic components provide a self-organizing mechanism for chromosome segregation and modulation of its timing across growth rates in Escherichia coli.

Restoring the Kv1-mediated pause in striatal cholinergic interneurons by reducing D5 receptor activity may help recover striatal function lost in dyskinetic parkinsonian mice.

AlphaFold-guided in vitro and in vivo analyses establish the mechanism of ULK complex formation and provide a structural basis for understanding its role in mammalian autophagy initiation.

Therapeutic hypothermia mitigates ventilator-induced lung injury by suppressing macrophage-derived IL-1β release, thereby reducing neutrophil extracellular trap formation, vascular leakage, and hypoxemia in a two-hit acute lung injury model.

Activation of NMB/GRP receptors is not necessary for sigh generation, while SST preBötC neurons are critical for generation of sighs.

The TRPV4 channel was identified as an obligatory regulator of physiological and pathological increases in intraocular pressure.

Dynamic shifts in neural coding combined with stable population subspaces enable visual areas to concurrently represent sensory inputs and working memory without mutual interference.