Friederike Steenken, Rainer Beutelmann ... Georg M Klump
In aging gerbils, compromised temporal fine structure perception is explained by a more prominent representation in auditory nerve fibers of temporal fluctuations of the signal envelope, rather than by synaptopathy.
Mark van der Kroeg, Sakshi Bansal ... Femke MS de Vrij
Human stem cell-derived adherent cortical organoids in 384-well plates provide a reproducible, long-term cortical organoid platform with neurons, glia, and robust network activity, enabling scalable disease modeling and therapeutic screening.
Theoretical and computational analyses demonstrate that cell intercalation within epithelial cell layers is analogous to the unbinding of topological defects in hexatic liquid crystals, offering a framework for calculating cellular forces and velocities during collective migration.
Allocating space, materials and energy to an eye's optics and photoreceptor array is a major factor in eye design that explains obvious differences between simple eyes and compound eyes.
RadD recognition by NKp46 converts Fusobacterium nucleatum from an immune-evasive pathogen into a trigger of natural killer cell-mediated tumor control in a context-dependent manner.
Residual plasma from rapid routine clinical chemistry tubes enables cell-free DNA NGS-based analysis, providing an untapped, scalable, and accessible resource without specialized collection workflows.
During convergent extension morphogenesis, non-canonical Wnt induces the signal transducer Dishevelled to transition from Vangl to Frizzled, a process that is inhibited by Prickle but facilitated by the co-receptor Ror.
An on-demand seizure model in chronically epileptic mice integrates reliability and etiological relevance, providing a mechanistically grounded, efficient platform for evaluating pharmacological interventions.
Chengcheng Fan, Alexander A Cohen ... Magnus AG Hoffmann
Bivalent EABR mRNA boosters broaden neutralizing responses to Omicron subvariants by promoting diverse receptor-binding domain epitope targeting, although antibody responses remain partially shaped by immune imprinting from prior vaccination.
