Modeling approaches demonstrate utility for incidence and reproductive number prediction and have potential to complement traditional surveillance in real time to guide public health interventions.
The Mettl5/Trmt112 complex alters rRNA methylation, increasing PERIOD protein linking ribosome function, clock genes, and proteasome in sleep regulation in Drosophila.
Humans’ flexible temporal cognition, including mental time travel, arises from perspective-agnostic encoding of event sequences in the hippocampus and perspective-dependent retrieval and reconstruction in the posterior parietal cortex.
David Ocampo, Carlos Daniel Cadena ... Gustavo A Londoño
In Neotropical birds, eggshells show that water vapor conductance declines with elevation, but structural responses vary across species, suggesting no single underlying mechanism and highlighting the need to further evaluate eggshell traits as determinants of elevational limits.
A high-resolution 3D imaging platform reveals the periportal lamellar complex as a novel structural feature in the mouse liver, regulating bile duct and nerve migration during fibrosis.
High levels of circulating estradiol enable the RP3V kisspeptin neuron population to exhibit long-lasting synchronized oscillatory behavior that drives GnRH neurons to initiate the LH surge.
Alicja Monaghan, Richard AI Bethlehem ... Duncan E Astle
Contrary to prior work, principal axes of structural and functional connectivity are established early in life, remaining stable and undergoing refinement throughout development.
Sara M Frangos, Henver S Brunetta ... Graham P Holloway
Multi-omic and bioenergetic profiling in a HER2-driven mouse model of mammary cancer reveals that reduced mitochondrial content does not limit tumor respiratory capacity, which is instead dramatically elevated compared to benign mammary tissue.
Continuous flash suppression reduces V1 orientation responses in an ocular-dominance-dependent manner, which may still allow low-level coarse orientation discrimination but provide insufficient information for higher-level visual and cognitive tasks.
The first all-atom models of the mycobacterial outer membrane reveal how lipid organization and asymmetry generate a structurally heterogeneous barrier that underlies its unique permeability properties.
