Browse our Research Articles

Page 8 of 1,371
    1. Ecology
    2. Evolutionary Biology

    Reconstructing the phylogeny and evolutionary history of freshwater fishes (Nemacheilidae) across Eurasia since early Eocene

    Vendula Bohlen Šlechtová, Tomáš Dvořák ... Joerg Bohlen
    The first comprehensive reconstruction of the evolutionary history of freshwater animals, on example of family Nemacheilidae, across Eurasia with the identification of the main tectonic, geological, and climatic factors influencing it has been described.
    1. Cell Biology

    Small-molecule activation of TFEB alleviates Niemann–Pick disease type C via promoting lysosomal exocytosis and biogenesis

    Kaili Du, Hongyu Chen ... Dan Li
    Small-molecule agonists of transcription factor EB alleviate Niemann–Pick disease type C via promoting lysosomal function.
    1. Cell Biology

    Stratification of enterochromaffin cells by single-cell expression analysis

    Yan Song, Linda J Fothergill ... Gene W Yeo
    Molecularly defined serotonin (enterochromaffin) cells of the gut lining were distinguished by single-cell expression analysis, in situ hybridization, and immunohistochemistry into 14 topographically organized clusters, with features implying that they are functionally distinct classes of serotonin cells.
    1. Developmental Biology

    A-to-I RNA editing of CYP18A1 mediates transgenerational wing dimorphism in aphids

    Bin Zhu, Rui Wei ... Pei Liang
    Binding of miR-3036-5p to CYP18A1 can be prevented by an A-to-I RNA editing, thus elevating CYP18A1 expression, decreasing 20E titer, and finally regulating the wing dimorphism of offspring in aphid.
    1. Neuroscience

    Visual routines for detecting causal interactions are tuned to motion direction

    Sven Ohl, Martin Rolfs
    Visual adaptation in humans revealed that the perception of causality was tuned to the direction of motion while the adaptation transferred across different motion speeds and colors.
    1. Neuroscience

    Synaptic deregulation of cholinergic projection neurons causes olfactory dysfunction across five fly Parkinsonism models

    Ulrike Pech, Jasper Janssens ... Patrik Verstreken
    A new Drosophila collection of Parkinsonism models reveals early synaptic cholinergic projection neuron dysfunction, linking synaptic failure to later dopaminergic decline, highlighting a role for cholinergic modulation in dopaminergic neuron health.
    1. Neuroscience

    Serotonin modulates infraslow oscillation in the dentate gyrus during non-REM sleep

    Gergely F Turi, Sasa Teng ... Yueqing Peng
    Rhythmic release of serotonin organizes infraslow oscillatory activity of the dentate gyrus during sleep.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Control of pili synthesis and putrescine homeostasis in Escherichia coli

    Iti Mehta, Jacob B Hogins ... Larry Reitzer
    Putrescine has a homeostatic network that controls pili synthesis and energy metabolism.
    1. Stem Cells and Regenerative Medicine

    Simultaneous cyclin D1 overexpression and p27kip1 knockdown enable robust Müller glia cell cycle reactivation in uninjured mouse retina

    Zhifei Wu, Baoshan Liao ... Wenjun Xiong
    A novel strategy is described for stimulating a large number of Müller glia to proliferate in mice by manipulating cell cycle components without a damage stimulus.
    1. Developmental Biology

    Neuroprotective role of Hippo signaling by microtubule stability control in Caenorhabditis elegans

    Hanee Lee, Junsu Kang ... Junho Lee
    The Hippo pathway maintains the integrity of differentiated neurons by modulating microtubule stability, and reducing microtubule stability of fully developed neurons offers a potential strategy to delay neuronal aging.