Flexible evidence accumulation in dynamic environments relies on multiple mechanisms, including context-dependent modulations of sensory adaptation and pupil-linked arousal.
Isabelle G Henshall, Jill Chmielewski ... Danny W Wilson
Pathogens can use surface proteins to limit immune responses, and the finding that merozoite surface protein 2 has this property could help in Plasmodium falciparum malaria vaccine development.
Endosomes operate several exit routes that sort protein cargo and depend on pathway-specific associations of a PROPPIN with the responsible protein coat, such as the here identified CROP2, to support the departure of the cargo carriers.
Elena Spinetti, Grzegorz Ścibisz ... Roberto Covino
A unified structural model of IRE1 activation reconciles conflicting sensing theories by characterizing specific peptide-binding sites and the mechanism by which BiP regulates oligomerization during the unfolded protein response.
Invasive Lantana camara exhibits strong genetic structure, unlike many invasive species, likely driven by predominant self-fertilization across its invasive range rather than the presence of multiple species.
Fangrui Guo, Roberto Ornelas Guevara ... Guy Tran Van Nhieu
Through low levels of extracellular ATP, EPEC induces small, rapid and coordinated Ca2+ responses in epithelial cells, a yet unreported pattern, that down-regulate inflammation at the onset of infection.
Revathi Balasubramanian, Nicholas Tolman ... Simon WM John
High-resolution single-cell transcriptomics reveals the molecular programs and signaling networks driving Schlemm's canal and trabecular meshwork development, establishing a foundation for understanding glaucoma pathogenesis.
Morena Raiola, Miquel Sendra Sendra ... Miguel Torres
A computational pipeline leverages mammalian heart development videos to extract tissue deformation patterns and generate a virtual fate map tool that provides new insights into cardiac morphogenesis.
