Psilocin induces a durable neuroplastic state in human cortical neurons by enhancing BDNF signaling, neurite complexity, synaptogenesis, and synaptic network activity through 5-HT2A receptor-dependent mechanisms.
Air pollution activates macrophage-derived artemin, sensitizing TRPA1 nociceptors to drive neutrophilic asthma, revealing new therapeutic targets for refractory airway inflammation.
Marilina Raices, Fabiola Balmir ... Judith L Yanowitz
HIM-5 emerges as a central scaffold that coordinates SPO-11 accessory complexes to control different aspects of meiotic DNA double-strand breaks, ensuring robust crossover formation on autosomes and the X chromosome.
Uev1A and APC/C degrade CycA to counteract oncogenic Ras, thereby protecting against cell death in polyploid Drosophila nurse cells and suppressing overgrowth in diploid germline and human colorectal tumor cells.
A DNA origami nanospring introduces a force-sensing technology that enables measurement of motor protein stall forces without optical trapping, detecting force changes in kinesin KIF1A and its disease-related mutants.
Independent experimental approaches demonstrate changes in TFAM binding to UVC-irradiated DNA, providing a potential mechanism for DNA damage sensing in the mitochondria.
Yiyi Yu, Jeffery N Stirman ... Spencer LaVere Smith
Activity fluctuations, or noise correlations, are robust measures of neuronal connectivity and they reveal that neural circuity controls mixing of information at a granular level across millimeter-length scales.
