Browse our Research Articles

Page 8 of 1,459
    1. Neuroscience

    Between-species variation in neocortical sulcal anatomy of the carnivoran brain

    Magdalena Boch, Katrin Karadachka ... Rogier B Mars
    A large-scale investigation of carnivoran brain diversity, providing a unified description of folding patterns, their relationship to behaviour and ecology, and the foundation for future investigations of carnivoran neuroecology.
    1. Neuroscience

    Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals

    Calum Stewart, T Adam Liddle ... Tyler J Stevenson
    Transcriptomic and genomic mutations reveal the mechanistic basis of timing seasonal life history transitions.
    1. Computational and Systems Biology

    Predicting the effect of CRISPR-Cas9-based epigenome editing

    Sanjit Singh Batra, Alan Cabrera ... Yun S Song
    Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based epigenome editing.
    1. Cell Biology

    Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance

    Atsushi Matsumoto, Akihito Inoko ... Junichi Ikenouchi
    Lipid imbalance triggered by Snail-driven epithelial–mesenchymal transition creates a cholesterol-dependent vulnerability that can be therapeutically targeted to overcome chemoresistance in cancer.
    1. Cell Biology
    2. Neuroscience

    Dilated cardiomyopathy-associated RNA-binding motif protein 20 regulates long pre-mRNAs in neurons

    Giulia Di Bartolomei, Raúl Ortiz ... Peter Scheiffele
    An alternative splicing regulator previously implicated in calcium signaling in the heart ensures cell-type-specific mRNA processing of long neuronal mRNAs in the mouse brain.
    1. Physics of Living Systems

    Linking complex microbial interactions and dysbiosis through a disordered Lotka–Volterra model

    Jacopo Pasqualini, Amos Maritan ... Samir Suweis
    Linking biological research with disordered-systems modeling, providing new insights into gut microbiome stability, functioning, and their relationship with health.
    1. Cell Biology

    Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake

    J Ignacio Gutierrez, Claudia Edgar, Jessica K Tyler
    Live imaging analyses in budding yeast reveal that calorie restriction and overexpression of the mRNA binding protein Ssd1 both block deleterious age-dependent iron uptake as a mechanism to extend lifespan.
    1. Neuroscience

    A geometric shape regularity effect in the human brain

    Mathias Sablé-Meyer, Lucas Benjamin ... Stanislas Dehaene
    fMRI and MEG results in adults and children show encoding of abstract geometric regularities in dorsal-parietal, temporal, and frontal regions, pointing to a system for symbolic geometric representation in humans.
    1. Biochemistry and Chemical Biology

    The interplay between biomolecular assembly and phase separation

    Giacomo Bartolucci, Ivar S Haugerud ... Christoph A Weber
    Biomolecular assembly typically promotes phase separation while the presence of coexisting phases alters assembly kinetics.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Short activation domains control chromatin association of transcription factors

    Vinson B Fan, Abrar A Abidi ... Max V Staller
    Single-molecule tracking of transcription factors in living cells revealed how mutations that make short activation domains stronger increased the fraction of transcription factor molecules bound to chromatin and led to longer residence times on chromatin.