Uev1A and APC/C degrade CycA to counteract oncogenic Ras, thereby protecting against cell death in polyploid Drosophila nurse cells and suppressing overgrowth in diploid germline and human colorectal tumor cells.
Marilina Raices, Fabiola Balmir ... Judith L Yanowitz
HIM-5 emerges as a central scaffold that coordinates SPO-11 accessory complexes to control different aspects of meiotic DNA double-strand breaks, ensuring robust crossover formation on autosomes and the X chromosome.
Independent experimental approaches demonstrate changes in TFAM binding to UVC-irradiated DNA, providing a potential mechanism for DNA damage sensing in the mitochondria.
Yiyi Yu, Jeffery N Stirman ... Spencer LaVere Smith
Activity fluctuations, or noise correlations, are robust measures of neuronal connectivity and they reveal that neural circuity controls mixing of information at a granular level across millimeter-length scales.
Matthew W Rozak, James R Mester ... Bojana Stefanovic
A novel pipeline for analyzing longitudinal two-photon microscopy data of cerebrovasculature in mice interrogates the vasculature network before and after optogenetic stimulation, revealing new insights into their coordination.
The severity of active tuberculosis in a high-burden population is not explained by host or pathogen genetic variation, suggesting a dominant role for social and environmental factors.
Maria Gädeke, Tom Eric Willems ... Johannes Schultz
Being responsible for a partner's adverse outcomes is associated with anterior insula activation, while the superior temporal sulcus tracks prediction errors for the partner's reward resulting from the participant's decisions.
Alejandro Rodriguez Gama, Tayla Miller ... Randal Halfmann
In-cell biophysical analyses identify a sequence-encoded energy storage function of innate immune adaptor proteins that allows cells to respond quickly and decisively to pathogenic signals.
Adam L Kenet, Sooraj Achar ... Grégoire Y Altan-Bonnet
An automated bioluminescent image analysis framework, maRQup, parametrizes tumor dynamics and provides quantitative metrics, enabling large-scale evaluation and optimization of preclinical cancer immunotherapies.
