The DRAM system enables antibody-free, bisulfite-free, and transcriptome-wide mapping of 5-methylcytosine in mRNA with high accuracy, stability, and sensitivity, even at ultralow RNA inputs.
Gut microbiota composition and sex hormones influence the immune response to methicillin-resistant Staphylococcus aureus gastrointestinal colonization in mice.
Marketa Jirouskova, Karel Harant ... Martin Gregor
A comprehensive proteomic map of liver fibrosis progression and healing in two mouse models identifies etiology-specific extracellular matrix components, laying the foundation for targeted antifibrotic therapies.
Jenny Chen, Phoebe R Richardson ... Hopi E Hoekstra
Single-nucleus RNA-sequencing of the hypothalamic preoptic area of monogamous and promiscuous deer mouse species reveals neuronal differences that may be responsible for innate changes in mating and parental care behavior.
CCR5 antagonists show promise for stroke cerebroprotection and recovery, although further preclinical evidence in clinically relevant domains could strengthen support for clinical translation.
The novel divisome complex of Chlamydia trachomatis contains elements of the divisome and elongasome from other bacteria, and it requires the chromosomal translocase, FtsK, for its assembly.
Molecular dynamics simulations reveal that lipid binding at antibody loops and framework regions stabilizes membrane interactions, providing molecular details for neutralization mechanisms and strategies for HIV-1 vaccine development.
Julieta Gomez-Frittelli, Gabrielle Frederique Devienne ... Julia A Kaltschmidt
Cadherin-6 (Cdh6) marks gut-intrinsic sensory neurons, and optogenetic activation of Cdh6+ sensory neurons is sufficient to evoke colonic motor complexes.
