Browse our Research Articles

Genetic approaches identify Rtf1-dependent transcriptional pausing as an essential mechanism governing the deployment of the cardiac gene program during myocardial differentiation from the mesoderm.

The mean, variance, and autocorrelation of glucose dynamics are independently associated with coronary plaque vulnerability.

BK and Ca_V1.3 channels interact early during biogenesis, assembling intracellularly before membrane localization, indicating coordinated processes for functional coupling.

A new CRISPR-based approach for tuning gene expression up and down allowed identification of how other genes' expression responds to changes of transcription factors.

Cryo-EM structures of human aquaporin AQP2 bound to the anti-trypanosomal drugs pentamidine and melarsoprol identify the molecular mechanism for drug-resistant sleeping sickness.

A context-driven memory model simulates a wide range of characteristics of waking and sleeping hippocampal replay, providing a new account of how and why replay occurs.

Exosome-associated THSD7A is identified as a key trigger of filopodia formation in cancer cells and neurons, revealing a novel pathway with implications for metastasis, neuronal connectivity, and other filopodia-dependent processes.

Prefoldin 5 stabilises neuronal microtubules and suppresses Tau-mediated neurotoxicity, offering a potential therapeutic target for tauopathies.

CDK2-mediated TBK1 degradation via Dtx4 represents a previously unrecognized regulatory mechanism that modulates antiviral immunity in fish.

Bioinformatics, RNA-protein interactions, and HuR-based functional studies demonstrated that the rs13900T allele modulates CCL2 transcript levels, providing a functional link between the CCL2 rs1024611G-rs13900T haplotype and disease susceptibility/progression.