Browse our Research Articles

Page 6 of 1,446
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Timely vaccine strain selection and genomic surveillance improve evolutionary forecast accuracy of seasonal influenza A/H3N2

    John Huddleston, Trevor Bedford
    Reducing vaccine development time from 12 months to 6 reduces forecasting error by 25%, while reducing lags in genome sequence submission reduces uncertainty of current clade frequencies by 50%.
    1. Developmental Biology
    2. Neuroscience

    Ptbp1 is not required for retinal neurogenesis and cell fate specification

    Haley Appel, Rogger P Carmen-Orozco ... Seth Blackshaw
    Loss of function of Ptbp1 in retinal progenitors leads to changes in RNA splicing but does not affect neurogenesis and cell fate specification.
    1. Structural Biology and Molecular Biophysics

    Crossover in aromatic amino acid interaction strength between tyrosine and phenylalanine in biomolecular condensates

    David De Sancho, Xabier Lopez
    Hydration modulates aromatic interactions, explaining why Tyr is a stronger sticker than Phe in aqueous environments like protein condensates but not in the cores of folded proteins.
    1. Neuroscience
    2. Physics of Living Systems

    Sub-surface deformation of individual fingerprint ridges during tactile interactions

    Giulia Corniani, Zing S Lee ... Hannes P Saal
    Sub-surface imaging demonstrates that vertical shear beneath fingertip ridges enables high mechanical spatial resolution to support tactile sensing.
    1. Cell Biology

    Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity

    Hannah Neiswender, Jessica E Pride ... Graydon B Gonsalvez
    Disease-associated mutations in BICD2 result in loss- and gain-of-function interactions and dynein hyperactivity.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The primate Major Histocompatibility Complex as a case study of gene family evolution

    Alyssa Lyn Fortier, Jonathan K Pritchard
    The Major Histocompatibility Complex region evolves via gene birth-and-death, resulting in short-lived genes, rapidly expanding gene subfamilies, and many gene fragments.
    1. Neuroscience

    Dorsal hippocampus mediates light–tone associations in male mice

    Julia S Pinho, Carla Ramon-Duaso ... Arnau Busquets-Garcia
    A light–tone sensory preconditioning task in male mice is developed revealing sex differences and demonstrating that dorsal, but not ventral, hippocampal CaMKII-positive neurons encode innocuous stimulus associations.
    1. Computational and Systems Biology
    2. Neuroscience

    The electrogenicity of the Na+/K+-ATPase poses challenges for computation in highly active spiking cells

    Liz Weerdmeester, Jan-Hendrik Schleimer, Susanne Schreiber
    The electrogenic Na+/K+-ATPase generates a slow activity-dependent feedback signal that influences the computation of excitable cells and requires additional compensatory mechanisms during periods of high sustained activity.
    1. Developmental Biology

    Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest

    Tim Casey-Clyde, S John Liu ... David R Raleigh
    Eed, a core subunit of Polycomb repressive complex 2, is required for craniofacial osteoblast differentiation and mesenchymal proliferation after induction of the neural crest.
    1. Neuroscience

    Cross-species standardised cortico-subcortical tractography

    Stephania Assimopoulos, Shaun Warrington ... Stamatios N Sotiropoulos
    By providing new ways to map cortico-subcortical connectivity patterns, the proposed cross-species tractography approaches directly allow novel comparative studies between the human and macaque brain and enable subsequent explorations of brain-behaviour/disease symptom associations across individuals.