Browse our Research Articles

Page 840 of 1,395
    1. Microbiology and Infectious Disease

    Rhabdo-immunodeficiency virus, a murine model of acute HIV-1 infection

    Rachel A Liberatore, Emily J Mastrocola ... Paul D Bieniasz
    A new animal model permits the in vivo study of HIV-1 entry, as well as the elicitation and antiviral activity of antibodies, in a genetically manipulatable host.
    1. Ecology

    Multistability and regime shifts in microbial communities explained by competition for essential nutrients

    Veronika Dubinkina, Yulia Fridman ... Sergei Maslov
    Multistability and regime shifts are common and species diversity is high in microbial communities when nutrient supplies are balanced and competing species have different stoichiometries of essential nutrients.
    1. Biochemistry and Chemical Biology

    Non-enzymatic primer extension with strand displacement

    Lijun Zhou, Seohyun Chris Kim ... Jack W Szostak
    Relying on RNA fragments derived from degradation or partial template copying, non-enzymatic primer extension with strand displacement offers a novel and prebiotically plausible approach to RNA self-replication.
    1. Microbiology and Infectious Disease

    Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division

    Ruojun Wang, Kaj Kreutzfeldt ... Sabine Ehrt
    PerM-mediated FtsB stabilization is essential for cell division of Mycobacterium tuberculosis during chronic but not acute mouse infections.
    1. Neuroscience

    A projection specific logic to sampling visual inputs in mouse superior colliculus

    Katja Reinhard, Chen Li ... Karl Farrow
    Transsynaptic viral tracing reveals that neurons in the superior colliculus employ projection specific rules to the sampling of retinal inputs, directing distinct visual features to different downstream targets.
    1. Structural Biology and Molecular Biophysics

    Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870

    Ye Zhou, Can Cao ... Xuejun Cai Zhang
    The structure of receptor-ligand complex reveals the ligand binding selectivity among different dopamine receptor subtypes and also shows how this ligand class inhibits receptor activity.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    A microtranslatome coordinately regulates sodium and potassium currents in the human heart

    Catherine A Eichel, Erick B Ríos-Pérez ... Gail A Robertson
    Association of mRNA in discrete, cotranslational complexes regulates currents controlling excitability in human cardiomyocytes.
    1. Microbiology and Infectious Disease

    Perinatal hormones favor CC17 group B Streptococcus intestinal translocation through M cells and hypervirulence in neonates

    Constantin Hays, Gérald Touak ... Asmaa Tazi
    Hormonal concentrations found in over 7-day-old neonates favor CC17 GBS invasiveness in a process linked to intestinal M cells maturation and mediated by the CC17 GBS surface protein Srr2.
    1. Immunology and Inflammation

    Drosophila macrophages switch to aerobic glycolysis to mount effective antibacterial defense

    Gabriela Krejčová, Adéla Danielová ... Adam Bajgar
    Activated Drosophila macrophages undergo transient metabolic remodeling towards Hypoxia inducible factor 1 α-driven aerobic glycolysis, a program that induces systemic metabolic changes and is crucial for resistance to infection.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Profilin and formin constitute a pacemaker system for robust actin filament growth

    Johanna Funk, Felipe Merino ... Peter Bieling
    Profilin release from the filament end controls the speed of actin growth at physiological conditions.