Browse our Research Articles

Page 881 of 1,395
    1. Computational and Systems Biology
    2. Neuroscience

    Characterizing functional pathways of the human olfactory system

    Guangyu Zhou, Gregory Lane ... Christina Zelano
    Human primary olfactory cortical regions can be parcellated into anatomically distinct areas based on whole-brain functional connectivity profiles, suggesting distinct, parallel functional pathways in the human olfactory system.
    1. Neuroscience

    Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice

    Hongsheng Zhang, Anupama Sathyamurthy ... Lin Mei
    Enriched environment stimulates neuron generation in the hippocampus by a novel pathway involving Agrin, Lrp4, and Ror2.
    1. Developmental Biology

    Single-cell sequencing of neonatal uterus reveals an Misr2+ endometrial progenitor indispensable for fertility

    Hatice Duygu Saatcioglu, Motohiro Kano ... David Pépin
    Single-cell RNA sequencing of neonatal uterus revealed an Misr2+ endometrial stromal progenitor whose inhibition by ectopic administration of MIS caused uterine hypoplasia and infertility in adulthood.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters

    Nikolai Petkau, Harun Budak ... Gregor Eichele
    Acetylation of the circadian transcription factor BMAL1 by the acetyltransferase TIP60 is crucial for recruitment of the pause release factors to clock gene promoters and productive elongation of these genes.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    N-chlorination mediates protective and immunomodulatory effects of oxidized human plasma proteins

    Agnes Ulfig, Anton V Schulz ... Lars I Leichert
    N-chlorination, a reversible, oxidative modification, turns plasma proteins into holdase-like chaperones, potent activators of immune cells and pro-survival factors for phagocytic immune cells.
    1. Neuroscience

    Distinct ipRGC subpopulations mediate light’s acute and circadian effects on body temperature and sleep

    Alan C Rupp, Michelle Ren ... Tiffany M Schmidt
    Daily fluctuations versus transient perturbations in environmental light influence behavior and physiology through distinct circuits.
    1. Neuroscience

    Voluntary and involuntary contributions to perceptually guided saccadic choices resolved with millisecond precision

    Emilio Salinas, Benjamin R Steinberg ... Terrence R Stanford
    Looking away from a salient visual stimulus pits the reflexive urge to look toward it against the voluntary intention not to, and this conflict is resolved within tens of milliseconds.
    1. Computational and Systems Biology
    2. Developmental Biology

    Modularity, criticality, and evolvability of a developmental gene regulatory network

    Berta Verd, Nicholas AM Monk, Johannes Jaeger
    A new approach focusing on dynamic modularity helps overcome traditional challenges detecting modularity in complex adaptive systems.
    1. Neuroscience

    Conditional deletion of glucocorticoid receptors in rat brain results in sex-specific deficits in fear and coping behaviors

    Jessie R Scheimann, Rachel D Moloney ... James P Herman
    Development of a conditional glucocorticoid receptor knockdown rat model allows for high resolution anatomical, physiological and behavioral exploration into the role of glucocorticoid receptor signaling in defined cell populations.
    1. Developmental Biology
    2. Neuroscience

    The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop

    Merve Deniz Abdusselamoglu, Elif Eroglu ... Jürgen A Knoblich
    Odd-paired (opa) is required for the progression of temporal patterning in Drosophila neural progenitors to regulate temporal identities via an incoherent feed-forward loop.