Browse our Research Articles

The structure of the calcium channel Orai in an open conformation reveals a dilated pore and gives insight into mechanisms of ion permeation and calcium selectivity.

The biogenesis of lipid droplets induced by Wnt3a is controlled by the transcription factor TFAP2, which presumably acts as a 'master' regulator of lipid droplet biogenesis.

Retrograde transport of NT-3 stimulated the reorganization of lumbar neural circuitry and synaptic connectivity remote to a thoracic SCI, along with improved behavioral recovery.

Feeding and fasting associated alterations in proopiomelanocortin neuronal responses to insulin coordinate glucose metabolism.

Inactivation of the medial orbitofrontal cortex using an optogenetic approach did not affect behavior in rats on an iconic economic choice task.

Structure, dynamics, and mutation of a gamete fusion protein and comparisons to viral homologues suggest that after trimerization the domain bearing the membrane-inserting fusion loops can pivot with respect to the trimer 3-fold axis.

Early development involves both maternal and zygotic genetic effects. This dual genetic basis shapes the evolution of developmental mode in a marine annelid.

The site of ubiquinone binding observed in the cryo-EM structure of respiratory complex I during turnover supports a two-state stabilization change mechanism.

A widely studied chromatin modification associated with gene promoters is important for proper gene expression across organismal lifetime.

GpsB in Staphylococcus aureus directly regulates the central cell division protein FtsZ, a different function from that assigned for GpsB in other closely related organisms.