A neural gating mechanism in the external cuneate nucleus of the rat brain is engaged during wake movements and disengaged during sleep-related twitches.
Victoria E Pedanou, Stéphane Gobeil ... Michael R Green
A large-scale RNA interference screen uncovers a new transcriptional regulatory program involving the histone H3 demethylase KDM3A, which mediates detachment-induced apoptosis (anoikis) in breast epithelial cells.
Jonathan G Van Vranken, Mi-Young Jeong ... Jared Rutter
The essential function of ACP is not related to mitochondrial fatty acid and lipoic acid synthesis, but rather an evolutionarily-conserved role in iron sulfur cluster biogenesis.
The ability of hair cells to produce an electrical signal in response to a mechanical stimulus stems from tension in the elastic tip links within the bundles.
Patients with DYT1 dystonia show aberrant risk-aversion in a simple decision-making task, in accordance with predictions of a reinforcement learning model of corticostriatal trial-and-error learning.
A combination of optogenetics and 2-photon calcium imaging reveals spatial prerequisites for non-linear synaptic summation within a defined cortical connection.
A learning-induced, motor-related, projection-specific signal from S1 to S2 accompanies reward-based-learning of a goal-directed sensorimotor transformation of whisker sensation into licking motor output.
Zineb Mounir, Joshua M Korn ... Raymond A Pagliarini
The transcription factor ERG recruits the PRMT5 enzyme to methylate the androgen receptor, presenting a post-translational regulatory mechanism that could be therapeutically exploited to control cell proliferation.
