Browse our Tools and Resources

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    1. Genetics and Genomics

    Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors

    Joseph M Replogle, Jessica L Bonnar ... Marco Jost
    Newly developed, highly active CRISPR interference single guide RNA libraries and effectors together enable high-quality genetic screens across cell models.
    1. Genetics and Genomics

    Generating colorblind-friendly scatter plots for single-cell data

    Tejas Guha, Elana J Fertig, Atul Deshpande
    scatterHatch helps users generate colorblind-friendly scatter plot visualizations by using a combination of patterns and high-contrast colors to represent distinct point groups.
    1. Structural Biology and Molecular Biophysics

    A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0

    Jasenko Zivanov, Joaquín Otón ... Sjors HW Scheres
    New functionality in RELION-4.0 allows convenient structure determination from cryo electron tomography data to resolutions sufficient for de novo atomic modelling.
    1. Immunology and Inflammation

    The meningeal transcriptional response to traumatic brain injury and aging

    Ashley C Bolte, Daniel A Shapiro ... John R Lukens
    Transcriptional analyses provide an atlas of how traumatic brain injury and aging shape meningeal cell composition and gene expression.
    1. Neuroscience

    LabNet hardware control software for the Raspberry Pi

    Alexej Schatz, York Winter
    A software distributed platform for the Raspberry Pi to simplify and unify hardware access over the Ethernet network with almost real-time latencies.
    1. Genetics and Genomics

    An automated feeding system for the African killifish reveals the impact of diet on lifespan and allows scalable assessment of associative learning

    Andrew McKay, Emma K Costa ... Anne Brunet
    An automated feeding system to precisely control feeding in the killifish opens new areas to explore vertebrate lifespan, cognitive decline, dietary interventions, and drug screening in a high-throughput manner.
    1. Cell Biology
    2. Medicine

    Cellular features of localized microenvironments in human meniscal degeneration: a single-cell transcriptomic study

    Weili Fu, Sijie Chen ... Xuegong Zhang
    A single-cell transcriptome atlas reveals meniscal microenvironment variations during degeneration and cellular heterogeneity foundations of the inner–outer zone differences, suggesting novel cell subtypes as potential therapeutic targets.
    1. Neuroscience

    Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy

    Huasheng Yu, Jingwei Xiong ... Wenqin Luo
    Scratch-AID, a deep learning-based system for automatic quantification of mouse scratching behavior, could replace labor-intensive manual quantification and facilitate high through-put anti-itch drug screening.
    1. Physics of Living Systems

    The importance of intermediate filaments in the shape maintenance of myoblast model tissues

    Irène Nagle, Florence Delort ... Myriam Reffay
    Specific to muscles and essential for their development, desmin is revealed to be fundamental to the mechanics and shape maintenance of model muscle tissue even in early differentiating and unorganized systems through an integrated magnetic tensiometer approach.