Browse our Tools and Resources

Page 10 of 84
    1. Developmental Biology

    scRNA-sequencing in chick suggests a probabilistic model for cell fate allocation at the neural plate border

    Alexandre P Thiery, Ailin Leticia Buzzi ... Andrea Streit
    Neural plate border cells co-express neural, neural crest, and placodal transcriptional programs before cell fate decisions occur and are transcriptionally heterogeneous along the antero-posterior and medial-lateral axis.
    1. Neuroscience
    2. Physics of Living Systems

    Continuous odor profile monitoring to study olfactory navigation in small animals

    Kevin S Chen, Rui Wu ... Andrew M Leifer
    To study odor-guided navigation of small animals such as worms and fly larvae, a novel flow chamber and odor sensor array are presented that better characterize the odors that the animal experiences.
    1. Neuroscience

    State-dependent coupling of hippocampal oscillations

    Brijesh Modi, Matteo Guardamagna ... Francesco P Battaglia
    A novel analytical framework for investigation of simultaneously occurring brain oscillations (from either single or multiple brain areas) and how it modulates the underlying neuronal population during sleep and wakefulness (or other behavioral tasks).
    1. Neuroscience
    2. Physics of Living Systems

    Continuous, long-term crawling behavior characterized by a robotic transport system

    James Yu, Stephanie Dancausse ... Mason Klein
    Drosophila larvae manipulated by an automated system can be observed for 30+ hr, and new analysis methods of long-timescale trajectories reveal behavioral features previously inaccessible, such as a bimodal distribution of thermal navigation efficiency in individual animals.
    1. Cell Biology
    2. Developmental Biology

    Continuous muscle, glial, epithelial, neuronal, and hemocyte cell lines for Drosophila research

    Nikki Coleman-Gosser, Yanhui Hu ... Amanda Simcox
    Lineage-specific Drosophila cell lines provide in vitro models for cell, biochemical, and high-throughput analyses in defined cell types.
    1. Neuroscience

    Fine-grained functional parcellation maps of the infant cerebral cortex

    Fan Wang, Han Zhang ... Gang Li
    Advanced computational processing and analysis of functional MRI create the first comprehensive set of high-resolution cortical parcellations maps of infant brains.
    1. Cell Biology
    2. Computational and Systems Biology

    Determining growth rates from bright-field images of budding cells through identifying overlaps

    Julian MJ Pietsch, Alán F Muñoz ... Peter S Swain
    The BABY algorithm by estimating growth rates of individual cells from time-lapse microscopy images will help characterise the diversity in populations of budding cells, particularly differences in fitness.
    1. Microbiology and Infectious Disease

    Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission

    Anne L Sapiro, Beth M Hayes ... Seemay Chou
    Development of an enrichment method to facilitate RNA-sequencing of the Lyme disease pathogen from inside of ticks during a bloodmeal provides new candidates for genes important for disease transmission.
    1. Cell Biology

    Opto-RhoGEFs, an optimized optogenetic toolbox to reversibly control Rho GTPase activity on a global to subcellular scale, enabling precise control over vascular endothelial barrier strength

    Eike K Mahlandt, Sebastián Palacios Martínez ... Joachim Goedhart
    Optogenetic activation of Rho GTPases provides spatiotemporal control over endothelial cell shape and enables control over endothelial barrier function by manipulating the cell-cell overlap with blue light.
    1. Neuroscience

    Sharing neurophysiology data from the Allen Brain Observatory

    Saskia EJ de Vries, Joshua H Siegle, Christof Koch
    A growing community demand for open neurophysiology data calls for new standards and tools to help scientists share data from their experiments, find relevant datasets that others have collected, and track data reuse across the literature.