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Live human pancreatic α-cells can be purified effectively using zinc-based reaction probe diacetylated Zinpyr1 and cultured as pseudoislets without losing their viability and function.

A new mass spectrometry-based method to identify and quantify changes in a subcellular local protein environment shows the impact of deletion of a kinase the human malaria parasites export into the host cell.

Bactabolize is a pipeline for rapid and scalable production of accurate bacterial strain-specific metabolic models and growth phenotype predictions.

Many channelrhodopsins acidify cells, but two new ones do not.

The accuracy of the Hybrid Vocalization Localizer (HyVL) brings a revolution to the study of social vocalizations of rodents and other animals, where vocalizations often occur in close proximity, and will empower downstream analysis of sequence and semantic analyses.

A customizable open-source hardware and software platform for conducting diverse behavioral experiments in head-fixed mice.

New methods for statistical inference in representational similarity analysis were developed, tested thoroughly, and are made available in an open-source Python toolbox.

Incorporating cycle-consistency loss into a generative adversarial network creates a high-performance and robust 'aligner' of neural population activity, permitting a fixed intracortical brain computer interface to be used for months without recalibration and without requiring inference of a latent manifold.

Functional assays using zebrafish reveal that various microbial channelrhodopsins, guanylyl cyclase rhodopsin, and photoactivated adenylyl cyclases function as potent optogenetic tools, effectively controlling neural activity and cardiac function in zebrafish.

Animal G-protein-coupled bistable rhodopsins can regulate Gq- and Gi-mediated signaling in a light-dependent manner in neurons and cardiomyocytes, making them useful for analyzing the roles of GPCR signaling in vivo.