Browse our Tools and Resources

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    1. Genetics and Genomics
    2. Neuroscience

    Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosis

    Johanna Ganssauge, Sophie Hawkins ... Akshay Bhinge
    A novel human iPSC-derived model induces mislocalization of endogenous TDP-43 without mutations or stress, recapitulating key ALS features including deficits in neuronal loss and morphology, splicing errors, and microRNA dysregulation.
    1. Neuroscience

    Social rank-order stability of mice revealed by a novel food competition paradigm in combination with available space competition paradigms

    Meiqiu Liu, Yue Chen, Rongqing Chen
    Social status of mice in an established colony is stably expressed in several types of competition paradigms, including food and space competitions.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

    Leonid Peshkin, Enrico maria Daldello ... Catherine Jessus
    A comprehensive resource describes protein abundance and phosphorylation dynamics during Xenopus oocyte maturation, serving as an essential tool for investigating the molecular mechanisms driving meiotic progression.
    1. Neuroscience

    Heron, a Knowledge Graph editor for intuitive implementation of Python-based experimental pipelines

    George Dimitriadis, Ella Svahn ... Athena Akrami
    A Python-based, open source, GUI application for straightforward development and execution of scientific experiments over multiple machines.
    1. Neuroscience

    Inference technique for the synaptic conductances in rhythmically active networks and application to respiratory central pattern generation circuits

    Yaroslav Molkov, Anke Borgmann ... Jeffrey Smith
    A robust method to infer excitatory and inhibitory synaptic conductances from neuronal recordings reveals functional circuit organization in rhythmic networks.
    1. Cell Biology
    2. Neuroscience

    CellSeg3D, Self-supervised 3D cell segmentation for fluorescence microscopy

    Cyril Achard, Timokleia Kousi ... Mackenzie Weygandt Mathis
    Self-supervised deep learning models can accurately perform 3D segmentation of cell nuclei in complex biological tissues, enabling scalable analysis in settings with limited or no ground truth annotations.
    1. Computational and Systems Biology

    Artificial intelligence driven tumor risk stratification from single-cell transcriptomics using phenotype algebra

    Namrata Bhattacharya, Anja Rockstroh ... Debarka Sengupta
    SCellBOW is a language model-based scRNA-seq analysis method that identifies malignant cell subpopulations and infers marker-free survival risks using transfer learning.
    1. Cancer Biology
    2. Cell Biology

    Image-based identification and isolation of micronucleated cells to dissect cellular consequences

    Lucian DiPeso, Sriram Pendyala ... Emily M Hatch
    The development of an automated micronucleus segmentation program enables population-level comparisons between cells with and without micronuclei and defines a highly limited response to micronucleus formation or rupture.
    1. Structural Biology and Molecular Biophysics

    A comprehensive antigen-antibody complex database unlocking insights into interaction interface

    Yuwei Zhou, Wenwen Liu ... Jian Huang
    AACDB provides a comprehensive, manually curated antigen-antibody interface dataset with rich metadata, interaction annotations, and therapeutic target annotations to advance antibody drug development.
    1. Computational and Systems Biology
    2. Neuroscience

    MorphoCellSorter is an Andrews plot-based sorting approach to rank microglia according to their morphological features

    Sarah Benkeder, Son-Michel Dinh ... Jean-Christophe Comte
    MorphoCellSorter is a versatile, user-friendly tool that automates microglial morphology ranking, enabling standardized, reproducible analysis across diverse models, imaging techniques, and conditions using principal component analysis and Andrews plots.