Browse our Tools and Resources

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    1. Neuroscience

    Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing

    Aixin Zhang, Lei Jin ... Xiaoyin Chen
    Barcoded rabies virus tracing combined with single-cell RNAseq and in situ sequencing achieves high-throughput retrograde projection mapping and synaptic connectivity mapping at cellular resolution.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    A kinase to cytokine explorer to identify molecular regulators and potential therapeutic opportunities

    Marina Chan, Yuqi Kang ... Taranjit S Gujral
    KinCytE is a web-based platform that explores kinase-cytokine-driven signaling and its relevance to understanding and treating diseases linked to disruptions in these pathways.
    1. Neuroscience

    osl-dynamics, a toolbox for modeling fast dynamic brain activity

    Chetan Gohil, Rukuang Huang ... Mark W Woolrich
    A generative-model-based, unsupervised learning toolbox for characterizing oscillatory bursting and brain network dynamics in univariate or multivariate time series.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Comparative interactome analysis of α-arrestin families in human and Drosophila

    Kyung-Tae Lee, Inez KA Pranoto ... Jin-Wu Nam
    Unveiling the high-confidence protein–protein interaction networks of human and fly α-arrestins provides insights into conserved and species-specific functional roles depending on their protein domains and motifs.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Light-inducible protein degradation in E. coli with the LOVdeg tag

    Nathan Tague, Cristian Coriano-Ortiz ... Mary J Dunlop
    The LOVdeg tag is a versatile tool for bacterial optogenetics, offering modular, blue light-inducible protein degradation for a range of synthetic biology and metabolic engineering applications.
    1. Genetics and Genomics
    2. Neuroscience

    The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

    Lukas M Weber, Heena R Divecha ... Stephanie C Hicks
    Spatially-resolved transcriptomics and single-nucleus RNA-sequencing are applied to the human locus coeruleus to characterize the gene expression profiles of norepinephrine (NE) neurons and other cell populations in this critical brain region, with all data made publicly available.
    1. Computational and Systems Biology
    2. Neuroscience

    BrainPy, a flexible, integrative, efficient, and extensible framework for general-purpose brain dynamics programming

    Chaoming Wang, Tianqiu Zhang ... Si Wu
    BrainPy presents a general-purpose programming framework that enables efficient implementation, simulation, training, and analysis of brain dynamics models across multiple organization scales, ultimately facilitating the understanding of the complex neural mechanisms underlying brain functions.
    1. Immunology and Inflammation

    Illuminating T cell-dendritic cell interactions in vivo by FlAsHing antigens

    Munir Akkaya, Jafar Al Souz ... Billur Akkaya
    Novel antigen-targeting probes, featuring a cysteine-rich tag emitting fluorescence, offer unprecedented insight into antigen-specific immune responses.
    1. Chromosomes and Gene Expression

    Spatial chromatin accessibility sequencing resolves high-order spatial interactions of epigenomic markers

    Yeming Xie, Fengying Ruan ... Chong Tang
    SCA-seq enables simultaneous detection of spatial interactions, chromatin accessibility, and CpG methylation at single-molecule resolution, advancing multi-omics studies of genome spatial organization.
    1. Genetics and Genomics

    Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues

    Mingqi Zhou, Ian Tamburini ... Marcus M Seldin
    A population resource to investigate mechanisms of organ communication.