Browse our Tools and Resources

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    1. Genetics and Genomics
    2. Neuroscience

    Genomic stability of self-inactivating rabies

    Ernesto Ciabatti, Ana González-Rueda ... Marco Tripodi
    SiR does not revert to wild type when produced in high-TEVp cell lines, is non-toxic in vivo, maintains transsynaptic spreading capabilities and revertant mutations do not accumulate during in vivo experiments.
    1. Developmental Biology

    scMultiome analysis identifies embryonic hindbrain progenitors with mixed rhombomere identities

    Yong-Il Kim, Rebecca O'Rourke, Charles G Sagerström
    Combined single nucleus RNAseq and ATACseq enabled the first molecular resolution of all hindbrain rhombomeres, the derivation of a unique gene regulatory network for each rhombomere, and the identification of gene expression changes as rhombomeres form from early progenitor pools.
    1. Neuroscience

    Functional ultrasound imaging of stroke in awake rats

    Clément Brunner, Gabriel Montaldo, Alan Urban
    Functional ultrasound imaging was used to monitor brain hemodynamics and sensory-evoked thalamocortical functions in awake rats pre- and post-stroke, advancing our understanding toward new therapeutic developments.
    1. Neuroscience

    Mesotrode allows chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice

    Dongsheng Xiao, Yuhao Yan, Timothy H Murphy
    Low-profile tetrodes that are compatible with wide-field imaging provide the opportunity to evaluate the relationship between spiking neurons and broad networks.
    1. Neuroscience

    Evaluation of surface-based hippocampal registration using ground-truth subfield definitions

    Jordan DeKraker, Nicola Palomero-Gallagher ... Alan C Evans
    Surface-based registration of the folded or unfolded human hippocampus achieves subfield alignment to within approximately 0.5 mm.
    1. Computational and Systems Biology
    2. Neuroscience

    A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster

    Hannah Jones, Jenny A Willis ... Giorgio F Gilestro
    Coccinella, an open-source framework, combines real-time tracking on microcomputers with statistical learning, optimising behaviour analysis in Drosophila melanogaster while surpassing other advanced systems in throughput and performance.
    1. Developmental Biology

    Single-cell profiling coupled with lineage analysis reveals vagal and sacral neural crest contributions to the developing enteric nervous system

    Jessica Jacobs-Li, Weiyi Tang ... Marianne E Bronner
    Single-cell transcriptome analysis of sacral compared with vagal neural crest-derived cells in the developing chick enteric nervous system reveals both similarities and differences between these two cell populations.
    1. Cell Biology

    Independent regulation of Z-lines and M-lines during sarcomere assembly in cardiac myocytes revealed by the automatic image analysis software sarcApp

    Abigail C Neininger-Castro, James B Hayes ... Dylan Tyler Burnette
    Software is introduced for the rapid and comprehensive quantification of sarcomere-containing myofibrils and their precursors in cardiac myocytes, aiding in the advancement of cardiovascular cell biology investigations.
    1. Neuroscience

    Bayesian analysis of phase data in EEG and MEG

    Sydney Dimmock, Cian O'Donnell, Conor Houghton
    A Bayesian model of phase angles illustrates a novel approach to the analysis of phase coherence in frequency-tagged experiments.
    1. Neuroscience

    Pynapple, a toolbox for data analysis in neuroscience

    Guillaume Viejo, Daniel Levenstein ... Adrien Peyrache
    Pynapple advances data analysis in systems neuroscience with a versatile, open-source framework that uses common objects to handle diverse data streams, ensuring reliable and reproducible analysis while maintaining long-term backward compatibility.