Jianheng Fox Liu, Ben R Hawley ... Samie R Jaffrey
CROWN-seq provides the first precise and quantitative map of N6,2’-O-dimethyladenosine (m6Am) in mRNA and snRNA, revealing the link between m6Am modification and efficient transcription, rather than translation and RNA stability.
Jasper Janssens, Pierre Mangeol ... Frank Schnorrer
Spatial transcriptomics of adult Drosophila brain and body sections determined the spatial expression for 150 genes, which identified the locations of unknown neuronal cell types and transcriptional diversity within muscle.
Gabriel Loewinger, Erjia Cui ... Francisco Pereira
A fiber photometry analysis framework based on functional mixed models enhances the detection of effects by testing signal-variable associations at each trial timepoint and accounting for between-animal heterogeneity.
Barbora Rehak Buckova, Charlotte Fraza ... Jaroslav Hlinka
Normative modelling adapted for longitudinal neuroimaging enables precise evaluation of individual brain changes over time, revealing subtle disease dynamics and temporal patterns missed by traditional analytical approaches.
Mihály Vöröslakos, Yunchang Zhang ... György Buzsáki
The ThermoMaze behavioral paradigm enables the collection of extensive physiological data while animals remain at distinct experimenter-controlled locations during rest.
Philipp S O'Neill, Martín Baccino-Calace ... Igor Delvendahl
miniML, a deep learning-based method, facilitates synaptic event analysis with high accuracy and versatility across diverse synaptic preparations, enabling high-throughput investigations of neural function and dysfunction.
behaviorMate provides a flexible, open-source platform for in vivo investigations that relies on a network of devices to enable observation of neural activity during navigation using physical treadmill and VR setups.
The Apollo implant, an open-source device tested in eight laboratories, can be used to reversibly implant Neuropixels probes and track the activity of populations of neurons across days.
Jorge Blanco Mendana, Margaret Donovan ... Daryl M Gohl
A method for genetically barcoding Drosophila is developed and used to tag defined cell populations in vivo for single-cell transcriptomics experiments and to enable multiplexed behavioral analysis.
