Adding suppressors of spontaneous differentiation enables precise control of human induced pluripotent stem cell (hiPSC) status in suspension culture conditions and leads to scalable and automated cell therapy using hiPSCs.
Nishal Pradeepbhai Shah, AJ Phillips ... EJ Chichilnisky
A novel method of electrical stimulation to precisely control neural activity for sensory restoration exhibits improvements in visual stimulus reconstruction, enables efficient hardware design, and extends to naturalistic conditions.
Quantitative models for responses of rod and cone photoreceptors are developed that allow direct tests of the impact of the photoreceptors on responses of downstream visual neurons.
The Marmoset Apparatus for Automated Pulling provides a powerful and scalable experimental platform for studying behavioral and neural mechanisms underlying cooperation in freely moving marmosets.
Vincent Gardeux, Roel PJ Bevers ... Bart Deplancke
The DGRPool web tool aggregates phenotyping data from the Drosophila Genetic Reference Panel, streamlining genetic association studies and offering new insights into genetic and phenotypic variation in complex traits.
Expression pattern analysis of neurotransmitter synthesis, secretion, and reuptake machinery reveals animal-wide usage of neurotransmitters in both sexes of Caenorhabditis elegans.
Johannes Oppermann, Andrey Rozenberg ... Peter Hegemann
Engineered anion-conducting channelrhodopsins with enhanced red-light sensitivity and accelerated kinetics enable precise, low-intensity optical silencing of neurons, advancing optogenetic control in neuroscience research.
Over 2.8 million tissue-specific gene regulatory sequences are predicted for 33 insect genomes, using a simple computational workflow with only the genome sequence and a basic gene annotation as input.
Rion Brattig-Correia, Joana M Almeida ... Paulo Navarro-Costa
An interdisciplinary research platform reveals that the transcriptional identity of metazoan male germ cells is built around a small network of deeply conserved gene interactions with an overarching functional impact.