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    1. Neuroscience

    PTBP1 depletion in mature astrocytes reveals distinct splicing alterations without neuronal features

    Min Zhang, Naoto Kubota ... Sika Zheng
    PTBP1 loss in mature astrocytes causes unique astrocytic splicing changes, not neuronal-like, contrasting its role in other non-neuronal cells and indicating PTBP1 depletion alone is ineffective to drive adult-astrocyte-to-neuron conversion.
    1. Developmental Biology
    2. Evolutionary Biology

    HoxB-derived hoxba and hoxbb clusters are essential for the anterior–posterior positioning of zebrafish pectoral fins

    Morimichi Kikuchi, Renka Fujii ... Akinori Kawamura
    HoxB-dependent anterior–posterior patterning and the evolutionary origin of pectoral fins.
    1. Neuroscience

    Functional characterization of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome

    Xiao Cong, Huachen Liu ... Muyan Chen
    Cell-line experiments and in vivo functional experiments provide the evidence that CT-type peptides can act as ligands for both CTR/CLR-type and PDF-type receptors in a deuterostome.
    1. Neuroscience

    Hierarchical Bayesian modeling of multiregion brain cell count data

    Sydney Dimmock, Benjamin MS Exley ... Cian O'Donnell
    Bayesian hierarchical models offer powerful statistical tools for neuroscientists to analyze whole-brain cell count data, as demonstrated here using two example datasets from different laboratories.
    1. Neuroscience

    Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer’s disease

    Julia J van Adrichem, Rolinka J van der Loo ... Ronald E van Kesteren
    Remote memories in Alzheimer’s disease are impaired through loss of inhibitory control over cortical engram neurons by hyperexcitable parvalbumin interneurons.
    1. Neuroscience

    Spatially heterogeneous inhibition projects sequential activity onto unique neural subspaces

    Andrew B Lehr, Arvind Kumar, Christian Tetzlaff
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology
    2. Neuroscience

    Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly

    Katherine X Dong, Hui Ji ... Colleen N McLaughlin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Synaptic density and relative connectivity conservation maintain circuit stability across development

    Ingo Fritz, Feiyu Wang ... André Ferreira Castro
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology

    Martinize2 and Vermouth provide a unified framework for molecular topology generation

    Peter C Kroon, Fabian Grünewald ... Siewert J Marrink
    Enabling high-throughput simulations of proteins within the Martini framework.
    1. Neuroscience

    A stochastic RNA editing process targets a select number of sites in individual Drosophila glutamatergic motoneurons

    Andrés B Crane, Michiko O Inouye ... J Troy Littleton
    Patch-seq RNA profiling defines the overall RNA editing landscape and single neuron editing rules for individual genetically defined Drosophila larval motoneurons.
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