Browse the latest research

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    1. Neuroscience

    Cholecystokinin modulates age-dependent thalamocortical neuroplasticity

    Xiao Li, Jingyu Feng ... Jufang He
    Cholecystokinin gates age-dependent auditory thalamocortical plasticity and, upon supplementation, reverses age-related plasticity decline and improves frequency discrimination.
    1. Cell Biology

    WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signaling

    Ankita B Jaykumar, Derk Binns ... Melanie H Cobb
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Immunology and Inflammation
    2. Cancer Biology

    Androgen deprivation triggers a cytokine signaling switch to induce immune suppression and prostate cancer recurrence

    Kai Sha, Renyuan Zhang ... John J Krolewski
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology

    Bidirectional translocation of actomyosin drives epithelial invagination in ascidian siphon tube morphogenesis

    Jinghan Qiao, Pengyu Yu ... Bo Dong
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Physics of Living Systems

    Emergent periodicity in the collective synchronous flashing of fireflies

    Raphael Sarfati, Kunaal Joshi ... Orit Peleg
    Fireflies that gather in swarms synchronize their flashing with rhythmic periodicity and provide insights into a new mechanism for the emergence of synchrony and periodicity.
    1. Biochemistry and Chemical Biology

    MCAK recognizes the nucleotide-dependent feature at growing microtubule ends

    Wei Chen, Yin-Long Song ... Xin Liang
    A key finding is that MCAK binds to the proximal region of GTP cap where GDP‧Pi-tubulins accumulate, in addition to curved protofilaments at the distalmost tip.
    1. Physics of Living Systems

    Quantifying the shape of cells, from Minkowski tensors to p-atic orders

    Lea Happel, Griseldis Oberschelp ... Axel Voigt
    Only rigorous mathematical tools to quantify the shape of cells can guarantee reliable results in coarse-grained descriptions of tissue dynamics.
    1. Plant Biology

    Life-cycle-related gene expression patterns in the brown algae

    Pélagie Ratchinski, Olivier Godfroy ... J Mark Cock
    Life-cycle- and development-related patterns of gene expression are conserved in diverse brown algae.
    1. Neuroscience

    Traveling waves across scales: Different mechanisms but same canonical computation?

    Laura Dugué, Frédéric Chavane
    The review proposes a novel mechanistic distinction between first- and second-order traveling waves that subserves a same canonical computation by ordering neuronal processing to impose a computational syntax.
    1. Microbiology and Infectious Disease

    The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

    Rahul K Suryawanshi, Priyadarshini Jaishankar ... James S Fraser
    The development of new small molecules demonstrates how pharmacologic inhibition of the coronavirus macrodomain restores innate immunity, leading to reduced viral replication and improved outcomes in severe infection.