Browse the latest research

Page 13 of 1,883
    1. Cancer Biology

    Loss of ZNRF3/RNF43 unleashes EGFR in cancer

    Fei Yue, Amy T Ku ... Yi Li
    Genetic and biochemical analyses show that loss of the E3 ubiquitin ligases ZNRF3 and RNF43 enhances EGFR signaling by impairing EGFR ubiquitination and degradation, revealing a new cancer-promoting mechanism.
    1. Immunology and Inflammation

    Contrasting roles for IKK-regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive γδ T cells

    Farjana Islam, Cayman Williams ... Benedict Seddon
    Inhibitor of κB kinase signalling differentially controls development and survival of γδ T cell subsets through nuclear factor-κB activation and repression of receptor-interacting protein kinase 1-driven necroptosis, revealing distinct inflammatory signalling requirements from αβ T cells.
    1. Neuroscience

    Stimulus dependencies—rather than next-word prediction—can explain pre-onset brain encoding in naturalistic listening designs

    Inés Schönmann, Jakub Szewczyk ... Micha Heilbron
    The ability to predict brain activity from words before they occur can be explained by information shared between neighbouring words, without requiring next-word prediction by the brain.
    1. Immunology and Inflammation

    Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation

    Dana MS Cheung, Momchil Razsolkov ... J Simon C Arthur
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    Separation slang – Laboratory mice use low-frequency call repertoire during physical separation

    Daniel Breslav, Michal Wojcik ... Thorsten Becker
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Immunology and Inflammation

    ImPaqT - A Golden Gate-based Toolkit for Zebrafish Transgenesis

    Saskia Hurst, Christiane Dimmler, Mark R Cronan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Developmental Biology

    Genetically engineered ESC-derived embryos reveal Vinculin-dependent force responses required for mammalian neural tube closure

    Ian S Prudhomme, Eric R Brooks ... Jennifer A Zallen
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Evolutionary Biology

    Design and experimental characterization of specificity-switching mutational paths of WW domains

    Ahmed Rehan, Eugenio Mauri ... Simona Cocco
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Evolutionary Biology

    The adaptive landscapes of three global Escherichia coli transcriptional regulators

    Cauã Antunes Westmann, Leander Goldbach, Andreas Wagner
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing