Gabriel Valentin Senn, Leon Nissen, Yaakov Benenson
Design and integration of various biomolecular sensors for over-activated rat sarcoma (RAS) created synthetic gene circuits that distinguish mutant versus wild-type signaling and express a therapeutic protein to kill RAS-driven cancer cells.
Lauri Nurminen, Maryam Bijanzadeh, Alessandra Angelucci
The trial-to-trial variability of neuronal responses and the correlated response variability among neurons are modulated by visual stimulus size in a manner that depends on cortical layer, suggesting multiple circuits and mechanisms as the source of variability.
Visible light engages a non-visual, bZIP-dependent transcriptional pathway in peripheral tissues that communicates with the nervous system to shape behavioral plasticity and memory, enabling optogenetic-like gene control without photoreceptors.
Saccades selectively disrupt spatial but not colour memory, and while transsaccadic updating remains resilient to ageing and neurodegeneration, individual drawing deficits arise from impaired initial encoding and memory decay.
