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    1. Immunology and Inflammation

    DGKα and ζ deficiency causes regulatory T-cell dysregulation, destabilization, and conversion to pathogenic T-follicular helper cells to trigger IgG1-predominant autoimmunity

    Lei Li, Hongxiang Huang ... Xiao-Ping Zhong
    Diacylglycerol kinases (DGKs) α and ζ secure Treg stability, enforce CD28-dependence, and block conversion to pathogenic Tfh cells, safeguarding against autoimmune disease.
    1. Cell Biology

    Defective neuronal differentiation in Lowe syndrome is associated with mitochondrial dysfunction and impaired cilia-related Sonic Hedgehog signaling

    Grzegorz Walkiewicz, Siyu Chen ... Yang Sun
    OCRL deficiency is associated with mitochondrial dysfunction, altered ciliary signaling, and disrupted neural cell-state regulation across multiple experimental models of Lowe syndrome.
    1. Physics of Living Systems

    Intracellular mechanical fingerprint reveals cell type-specific mechanical differences

    Till M Muenker, Kerstin von Roden ... Timo Betz
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Plant Biology

    Improving rice drought tolerance through host-mediated microbiome selection

    Alex Styer, Dean Pettinga ... Devin Coleman-Derr
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    VDAC2 stabilizes a membrane-inserted, primed intermediate of BAX activation

    Varun Ravishankar, Laidy M Alvero-González ... Lucie Bergdoll
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology

    Loss of canonical sex steroid signaling correlates with prostate cancer progression and induces tumor escape in Drosophila

    Marine Vialat, Elissa Baabdaty ... Cyrille de Joussineau
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    Syntaxin11 Deficiency Inhibits CRAC Channel Priming to Suppress Cytotoxicity and Gene Expression in T Lymphocytes Independent of Membrane Trafficking

    Sritama Datta, Abhikarsh Gupta ... Monika Vig
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Probing the role of sequential sampling and integration in decisions about protracted, noiseless stimuli

    Hadiseh Hajimohammadi, Kieran S Mohr ... Simon P Kelly
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Blood-derived dietary protein promotes sleep in the mosquito Aedes aegypti

    Jiwei Zhang, Hitoshi Tsujimoto ... Alex C Keene
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Individual Taste Preferences Predict Cortical Taste Dynamics but Are Modified by Experience

    Kathleen C Maigler, Jian-You Lin ... Donald B Katz
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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