Browse the latest research

Page 147 of 1,780
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Lipid discovery enabled by sequence statistics and machine learning

    Priya M Christensen, Jonathan Martin ... Kelli L Palmer
    A previously unknown lipid modification by a bacterial antibiotic resistance enzyme was identified through the analysis of a family of antibiotic resistance enzyme sequences with a machine learning approach.
    1. Neuroscience

    Semantic relatedness proactively benefits learning, memory, and interdependence across episodes

    Kelly A Bennion, Jade Phong ... James W Antony
    Increasing semantic relationships with old information accelerates learning and enhances memory for new information and increases the likelihood of both old and new information being recalled together.
    1. Cell Biology

    UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins

    Satoshi Ninagawa, Masaki Matsuo ... Kazutoshi Mori
    The fate of glycoproteins in the endoplasmic reticulum whether they are directed toward folding or targeted to degradation depends on a tug of war between UGGT1 and EDEM family proteins.
    1. Microbiology and Infectious Disease

    Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens

    Francesca Torelli, Diogo M da Fonseca ... Moritz Treeck
    Secreted effector proteins of Toxoplasma gondii parasites create a supportive immune environment in mice, allowing individually less fit mutants to thrive and evade detection by in vivo CRISPR screens.
    1. Neuroscience

    Male rats emit aversive 44-kHz ultrasonic vocalizations during prolonged Pavlovian fear conditioning

    Krzysztof Hubert Olszyński, Rafał Polowy ... Robert Kuba Filipkowski
    When exposed to prolonged stressful stimulation, rats start to emit long, frequency-unmodulated 44-kHz ultrasonic vocalizations, usually within the 35–50 kHz range, along with, previously described, long and unmodulated 22-kHz ultrasonic vocalizations.
    1. Chromosomes and Gene Expression

    Prolonged cell cycle arrest in response to DNA damage in yeast requires the maintenance of DNA damage signaling and the spindle assembly checkpoint

    Felix Y Zhou, David P Waterman ... James E Haber
    Cell cycle arrest in response to a double-stranded break is initially maintained by the DNA damage checkpoint and later by the spindle assembly checkpoint.
    1. Developmental Biology

    Molecular, cellular, and developmental organization of the mouse vomeronasal organ at single cell resolution

    Max Henry Hills, Limei Ma ... C Ron Yu
    A transcriptomic atlas of the mouse vomeronasal organ reveals novel receptor co-expression patterns and provides a framework for understanding sensory neuron lineage and receptor specification.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity

    Simei Go, Constantinos Demetriou ... Eric O Neill
    Tissue-resident natural killer cells are important mediators of CD8 T responses in human cancers and these cells can be harnessed to increase immunity against pancreatic ductal adenocarcinoma.
    1. Neuroscience

    A novel image segmentation method based on spatial autocorrelation identifies A-type potassium channel clusters in the thalamus

    Csaba Dávid, Kristóf Giber ... Laszlo Acsady
    The spatial autocorrelation method Local Moran’s I was used for image segmentation to delineate pixel clusters representing congruous objects with fuzzy borders, in this case potassium ion channel clusters.
    1. Immunology and Inflammation

    SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire

    Somen K Mistri, Brianna M Hilton ... Jonathan E Boyson
    The SLAM/SAP signaling pathway regulates both γδ T cell developmental programming and γδ/αβ T cell lineage commitment.