β-CTF of APP, not Aβ, induces synaptic loss in a cell-autonomous manner, revealing APP misregulation may contribute to the pathogenesis of Alzheimer's disease via an Aβ-independent mechanism.
HSV-ΔICP34.5 reactivates latent HIV by modulating PP1-HSF1 and NF-κB pathways, offering a potential HSV-vectored therapeutic vaccine for a functional cure.
The thickness of the periplasmic region is reduced in strains of pneumococcus that are deleted in genes responsible for the incorporation of teichoic acid in the cell envelope.
Benjamin Le Gac, Marine Tournissac ... Bruno Cauli
Increased neuronal activity of cortical pyramidal cells can paradoxically reduce cerebral blood flow via vasoconstriction mediated by glutamate and lipid messengers.
Simply crushed zizyphi spinosi semen not only ameliorates Aβ, tau, and α-synuclein pathology in dementia model mice, but also rejuvenates brain function by suppressing cellular senescence in normal aged mice.
