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    1. Cancer Biology

    FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation

    Chenxi Gao, Huaibin Ge ... Jing Hu
    Mice studies show that the 'just-right' balance optimal for BRAFV600E-induced cecal tumor formation can be achieved through FAK alteration.
    1. Genetics and Genomics
    2. Neuroscience

    The neuron-specific IIS/FOXO transcriptome in aged animals reveals regulatory mechanisms of cognitive aging

    Yifei Weng, Shiyi Zhou ... Coleen T Murphy
    Neuron-specific sequencing of aged wild-type, daf-2, and daf-16;daf-2 mutants revealed transcriptomic changes with age, and in longevity mutants, putative neuroprotective genes are upregulated, which are required for prolonged cognitive functions.
    1. Computational and Systems Biology

    Accurate prediction of CDR-H3 loop structures of antibodies with deep learning

    Hedi Chen, Xiaoyu Fan ... Boxue Tian
    A deep learning-based toolkit predicting the 3D structures of monoclonal antibodies and nanobodies outperforms other current computational methods.
    1. Immunology and Inflammation

    Elevated glycolytic metabolism of monocytes limits the generation of HIF1A-driven migratory dendritic cells in tuberculosis

    Mariano Maio, Joaquina Barros ... Luciana Balboa
    A newly identified immunometabolic mechanism clarifies the aberrant trafficking of dendritic cells to lymph nodes in tuberculosis.
    1. Medicine
    2. Computational and Systems Biology

    Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning

    Gitanjali Roy, Rameesha Syed ... Michael A. Kalwat
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Fitness landscape of substrate-adaptive mutations in evolved amino acid-polyamine-organocation transporters

    Foteini Karapanagioti, Úlfur Águst Atlason ... Sebastian Obermaier
    Secondary active transporters can evolve to accommodate a broader range of substrates without losing their original substrate specificities.
    1. Neuroscience

    Reconfigurations of cortical manifold structure during reward-based motor learning

    Qasem Nick, Daniel J Gale ... Jason Gallivan
    Dimensionality reduction approaches on functional MRI data reveal that human reward-based motor learning emerges from dynamic changes in functional brain network interactions among sensorimotor, attention, and default mode networks.
    1. Developmental Biology

    Obox4 promotes zygotic genome activation upon loss of Dux

    Youjia Guo, Tomohiro Kitano ... Haruhiko Siomi
    Analysis of mouse zygotic genome activation (ZGA) reveals that a mis-annotated multicopy homeobox gene Obox4 functions redundantly with Dux to promote ZGA.
    1. Neuroscience

    Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus

    Eugene Gil, Sung Jun Hong ... Daniel A. Lim
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid